Personalized Medicine in Infections: from Systems Biomedicine and Immunometabolism toPrecision Diagnosis and Stratification Permitting Individualized Therapies

PerMIT focuses on life-threatening infectious diseases, including the destructive necrotizing soft tissue infections and sepsis. The severity of these infections is dictated by the individual’s response to the pathogen and greatly depends on subject-specific host-pathogen interactions. For this reason, personalized therapeutic strategies targeting both pathogen and host response are needed.

To achieve this, the project builds on a transnational interdisciplinary team of clinicians, experimentalists, bioinformaticians and computational modellers from different EU countries. PERMIT will move towards preclinical validation of disease signatures, underlying mechanisms and biomarkers with the aim of translating these findings into improved or novel diagnostics.