Helping preterm infants to transition at birth in the most effective and least injurious way

Gesloten stembanden

Vòòr de geboorte zijn de stembanden van de foetus voornamelijk gesloten. We hebben aangetoond dat dit bij geboorte ook het geval is en alleen kortdurend openen als de tevroeggeborene een ademteug neemt. De ademhaling zal dan bij geboorte beter gestimuleerd en ondersteund moeten worden om met maskerbeademing de longen te beluchten. Het toedienen van cafeïne, een ademhalings-stimulant, via de navelstreng had een positief effect op de ademhaling bij geboorte. Tevens werd de ademhaling en zuurstofverzadiging bevorderd door het herhaaldelijk zachtjes wrijven van huid (tactiele stimulatie). Wel is gebleken dat bij geboorte de juiste hoeveelheid zuurstofvoorziening van essentieel belang was voor de regeling van de ademhaling. Terwijl zuurstof de voornaamste “driver” is voor de ademhaling, is het precisiewerk waarbij zowel te weinig als te veel zuurstof moet worden voorkomen.

Positieve luchtdruk

De ademhaling kan dan het beste ondersteund worden met het toedienen van een positieve luchtdruk, waarbij de beademingsdruk wordt aangepast aan de fysiologisch veranderingen die bij geboorte moeten plaatsvinden. Deze dynamische benadering (initieel hoge druk gevolgd door stapsgewijs afbouwen) bevorderde de mate van beluchting van de longen, de longdoorbloeding en ademhaling zonder dat er nadelige effecten optreden. Het wachten met afnavelen totdat de ademhaling goed op gang is gekomen lijkt dan weer een gunstig effect te hebben op de bloedsomloop van de tevroeggeborene.

Producten

Titel: Clinical aspects of incorporating cord clamping into stabilisation of preterm infants
Auteur: Knol, Ronny, Brouwer, Emma, Vernooij, Alex S N, Klumper, Frans J C M, DeKoninck, Philip, Hooper, Stuart B, te Pas, Arjan B
Magazine: Archives of Disease in Childhood
Titel: High-CPAP Does Not Impede Cardiovascular Changes at Birth in Preterm Sheep.
Auteur: Martherus T, Crossley KJ, Rodgers KA, Dekker J, Demel A, Moxham AM, Zahra VA, Polglase GR, Roberts CT, Te Pas AB*, Hooper SB*. (*shared senior authorship)
Magazine: Frontiers in Pediatrics
Titel: Comparison of Two Respiratory Support Strategies for Stabilization of Very Preterm Infants at Birth: A Matched-Pairs Analysis
Auteur: Martherus, Tessa, Oberthuer, André, Dekker, Janneke, Kirchgaessner, Christoph, van Geloven, Nan, Hooper, Stuart B., Kribs, Angela, te Pas, Arjan B.
Magazine: Frontiers in Medicine
Titel: Physiological-based cord clamping in preterm infants using a new purpose-built resuscitation table: a feasibility study
Auteur: Brouwer, Emma, Knol, Ronny, Vernooij, Alex S N, van den Akker, Thomas, Vlasman, Patricia E, Klumper, Frans J C M, DeKoninck, Philip, Polglase, Graeme R, Hooper, Stuart B, te Pas, Arjan B
Magazine: Archives of Disease in Childhood
Titel: Supporting breathing of preterm infants at birth: a narrative review
Auteur: Martherus, Tessa, Oberthuer, André, Dekker, Janneke, Hooper, Stuart B, McGillick, Erin V, Kribs, Angela, te Pas, Arjan B
Magazine: Archives of Disease in Childhood
Titel: Comparing the effect of two different interfaces on breathing of preterm infants at birth: A matched-pairs analysis.
Auteur: Kuypers KLAM, Lamberska T, Martherus T, Dekker J, Böhringer S, Hooper SB, Plavka R, Te Pas AB
Magazine: Resuscitation
Titel: Stimulating and maintaining spontaneous breathing during transition of preterm infants.
Auteur: Dekker J, van Kaam AH, Roehr CC, Flemmer AW, Foglia EE, Hooper SB, Te Pas AB
Magazine: Pediatric Research
Titel: High vs. Low Initial Oxygen to Improve the Breathing Effort of Preterm Infants at Birth: Study Protocol for a Randomized Controlled Trial.
Auteur: Dekker J, Hooper SB, Giera M, McGillick EV, Hutten GJ, Onland W, van Kaam AH, Te Pas AB.
Magazine: Frontiers in Pediatrics
Titel: The Effect of Initial High vs. Low FiO2 on Breathing Effort in Preterm Infants at Birth: A Randomized Controlled Trial.
Auteur: Dekker J, Martherus T, Lopriore E, Giera M, McGillick EV, Hutten J, van Leuteren RW, van Kaam AH, Hooper SB, te Pas AB.
Magazine: Frontiers in Pediatrics
Titel: The physiology of neonatal resuscitation
Auteur: Hooper, Stuart B., Kitchen, Marcus J., Polglase, Graeme R., Roehr, Charles C., te Pas, Arjan B.
Magazine: Current Opinion in Pediatrics
Titel: Physiological-based cord clamping in very preterm infants - Randomised controlled trial on effectiveness of stabilisation.
Auteur: Knol R, Brouwer E, van den Akker T, DeKoninck P, van Geloven N, Polglase GR, Lopriore E, Herkert E, Reiss IKM, Hooper SB, Te Pas AB
Magazine: Resuscitation
Titel: Effect of spontaneous breathing on umbilical venous blood flow and during delayed cord clamping in preterm lambs.
Auteur: Brouwer E, Te Pas AB, Polglase GR, McGillick EV, Böhringer S, Crossley KJ, Rodgers K, Blank D, Yamaoka S, Gill AW, Kluckow M, Hooper SB.
Magazine: Archives of Disease in Childhood - Fetal and Neonatal Edition
Titel: Supporting breathing of preterm infants at birth: a narrative review.
Auteur: Martherus T, Oberthuer A, Dekker J, Hooper SB, McGillick EV, Kribs A, Te Pas AB.
Magazine: Archives of Disease in Childhood - Fetal and Neonatal Edition
Titel: Effective ventilation: The most critical intervention for successful delivery room resuscitation
Auteur: Foglia, Elizabeth E., te Pas, Arjan B.
Magazine: Seminars in Fetal and Neonatal Medicine
Titel: Time to achieve desired fraction of inspired oxygen using a T-piece ventilator during resuscitation of preterm infants at birth
Auteur: Dekker, J., Stenning, F.J., Willms, L.J.F.B., Martherus, T., Hooper, S.B., te Pas, A.B
Magazine: Resuscitation
Titel: Repetitive versus standard tactile stimulation of preterm infants at birth – A randomized controlled trial
Auteur: Dekker, Janneke, Hooper, Stuart B., Martherus, Tessa, Cramer, Sophie J.E., van Geloven, Nan, te Pas, Arjan B.
Magazine: Resuscitation
Titel: Haemodynamic effects of prenatal caffeine on the cardiovascular transition in ventilated preterm lambs
Auteur: Binder-Heschl, Corinna, Crossley, Kelly, te Pas, Arjan, Polglase, Graeme, Blank, Douglas, Zahra, Valerie, Moxham, Alison, Rodgers, Karyn, Hooper, Stuart
Magazine: PLoS ONE
Titel: The effect of a face mask for respiratory support on breathing in preterm infants at birth.
Auteur: Kuypers KLAM, Lamberska T, Martherus T, Dekker J, Böhringer S, Hooper SB, Plavka R, Te Pas AB.
Magazine: Resuscitation
Titel: Reflexes that impact spontaneous breathing of preterm infants at birth: a narrative review.
Auteur: Kuypers K, Martherus T, Lamberska T, Dekker J, Hooper SB, Te Pas AB
Magazine: Archives of Disease in Childhood - Fetal and Neonatal Edition
Titel: European Resuscitation Council Guidelines 2021: Newborn resuscitation and support of transition of infants at birth.
Auteur: Madar J, Roehr CC, Ainsworth S, Ersdal H, Morley C, Rüdiger M, Skåre C, Szczapa T, Te Pas A, Trevisanuto D, Urlesberger B, Wilkinson D, Wyllie JP.
Magazine: Resuscitation
Titel: 10) Physiologic-Based Cord Clamping Maintains Core Temperature vs. Immediate Cord Clamping in Near-Term Lambs
Auteur: Blank DA, Crossley KJ, Kashyap AJ, Hodges RJ, DeKoninck PLJ, McGillick EV, Rodgers KA, Te Pas AB, Hooper SB, Polglase GR
Magazine: Frontiers in Pediatrics
Titel: Caffeine to improve breathing effort of preterm infants at birth: a randomized controlled trial
Auteur: Dekker, Janneke, Hooper, Stuart B, van Vonderen, Jeroen J, Witlox, Ruben S G M, Lopriore, Enrico, te Pas, Arjan B
Magazine: Pediatric Research
Titel: Optimizing oxygenation of the preterm infant directly at birth: focus of future studies.
Auteur: Dekker J, Hooper SB, Te Pas AB
Magazine: Journal of Pediatrics
Titel: Higher CPAP levels improve functional residual capacity at birth in preterm rabbits.
Auteur: Martherus T, Croughan MK, Crossley KJ, Wallace MJ, McGillick EV, Thio M, Roehr CC, Pearson JT, Lee K, Ruben G, Kitchen MJ, Te Pas AB*, Hooper SB*. (*shared senior authorship)
Magazine: Pediatric Research
Titel: Laryngeal closure impedes non-invasive ventilation at birth
Auteur: Crawshaw, Jessica R, Kitchen, Marcus J, Binder-Heschl, Corinna, Thio, Marta, Wallace, Megan J, Kerr, Lauren T, Roehr, Charles C, Lee, Katie L, Buckley, Genevieve A, Davis, Peter G, Flemmer, Andreas, te Pas, Arjan B, Hooper, Stuart B
Magazine: Archives of Disease in Childhood
Titel: Ductal Flow Ratio as Measure of Transition in Preterm Infants After Birth
Auteur: Brouwer E, Knol R, Hahurij ND, Hooper SB, Te Pas AB, Roest AAW
Magazine: Frontiers in Pediatrics
Titel: Increasing Respiratory Effort With 100% Oxygen During Resuscitation of Preterm Rabbits at Birth.
Auteur: Dekker J, Hooper SB, Croughan MK, Crossley KJ, Wallace MJ, McGillick EV, DeKoninck PLJ, Thio M, Martherus T, Ruben G, Roehr CC, Cramer SJE, Flemmer AW, Croton L, Te Pas AB*, Kitchen MJ*. (shared senior authorship)
Magazine: Frontiers in Pediatrics
Titel: The Changing Landscape in Supporting Preterm Infants at Birth.
Auteur: Te Pas AB, Hooper SB, Dekker J.
Magazine: Neonatology
Titel: The Breathing Effort of Very Preterm Infants at Birth
Auteur: Huberts, Tom J.P., Foglia, Elizabeth E., Narayen, Ilona C., van Vonderen, Jeroen J., Hooper, Stuart B., te Pas, Arjan B.
Magazine: Journal of Pediatrics
Titel: Neonatal resuscitation research: closing the gap.
Auteur: Te Pas A, Roehr CC, Foglia EE, Hooper S.
Magazine: Pediatric Research
Titel: The Effect of Initial Oxygen Exposure on Diaphragm Activity in Preterm Infants at Birth.
Auteur: van Leuteren RW, Scholten AWJ, Dekker J, Martherus T, de Jongh FH, van Kaam AH, Te Pas AB, Hutten J.
Magazine: Frontiers in Pediatrics
Titel: Tactile Stimulation to Stimulate Spontaneous Breathing during Stabilization of Preterm Infants at Birth: A Retrospective Analysis.
Auteur: Dekker J, Martherus T, Cramer SJE, van Zanten HA, Hooper SB, Te Pas AB
Magazine: Frontiers in Pediatrics
Titel: Tactile Stimulation to Stimulate Spontaneous Breathing during Stabilization of Preterm Infants at Birth: A Retrospective Analysis
Auteur: Dekker, Janneke, Martherus, Tessa, Cramer, Sophie J. E., van Zanten, Henriette A., Hooper, Stuart B., te Pas, Arjan B.
Magazine: Frontiers in Pediatrics
Titel: Effectiveness of Stabilization of Preterm Infants With Intact Umbilical Cord Using a Purpose-Built Resuscitation Table-Study Protocol for a Randomized Controlled Trial.
Auteur: Knol R, Brouwer E, Klumper FJCM, van den Akker T, DeKoninck P, Hutten GJ, Lopriore E, van Kaam AH, Polglase GR, Reiss IKM, Hooper SB, Te Pas AB.
Magazine: Frontiers in Pediatrics
Titel: Timing is everything
Auteur: te Pas, Arjan B
Magazine: Archives of Disease in Childhood
Titel: Physiologically based cord clamping stabilises cardiac output and reduces cerebrovascular injury in asphyxiated near-term lambs
Auteur: Polglase, Graeme R, Blank, Douglas A, Barton, Samantha K, Miller, Suzanne L, Stojanovska, Vanesa, Kluckow, Martin, Gill, Andrew W, LaRosa, Domenic, te Pas, Arjan B, Hooper, Stuart B
Magazine: Archives of Disease in Childhood
Titel: Effect of maternal oxytocin on umbilical venous and arterial blood flows during physiological-based cord clamping in preterm lambs.
Auteur: Stenning FJ, Polglase GR, Te Pas AB, Crossley KJ, Kluckow M, Gill AW, Wallace EM, McGillick EV, Binder C, Blank DA, Roberts C, Hooper SB
Magazine: PLoS ONE
Titel: Effect of breathing on venous return during delayed cord clamping: an observational study.
Auteur: Brouwer E, Knol R, Kroushev A, Van Den Akker T, Hooper SB, Roest AA, Te Pas AB.
Magazine: Archives of Disease in Childhood - Fetal and Neonatal Edition
Titel: Stimulating and maintaining spontaneous breathing of preterm infants at birth
Auteur: Janneke Dekker
Link: https://scholarlypublications.universiteitleiden.nl/handle/1887/77439
Titel: Physiological measurements of the effect of cord clamping strategies
Auteur: Emma Brouwer
Link: https://scholarlypublications.universiteitleiden.nl/handle/1887/3213482
Titel: Concord Neonatal BV
Auteur: https://concordneonatal.com/ © Concord Neonatal B.V. KvK 68648170 BTW: NL 857534683B01
Titel: method and apparatus for prevention of apnea
Auteur: Arjan te Pas, Sophie Cramer, Stuart Hooper
Titel: Concord, resuscitation table
Auteur: Inventor of a new resuscitation table (Concord), patented under PCT/NL2016/050928 (European patent application No. 15203251.2). This is a resuscitation table that makes physiology-based cord clamping possible.
Titel: De equilibrist
Auteur: A.B. te Pas
Link: https://www.universiteitleiden.nl/medewerkers/arjan-te-pas

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Kenmerken

Projectnummer:
91716428
Looptijd: 100%
2016
2021
Gerelateerde subsidieronde:
Projectleider en penvoerder:
Prof. dr. A.B. te Pas MD PhD
Verantwoordelijke organisatie:
Leiden University Medical Center