SGK1 inhibition as a novel therapeutic approach in Long QT syndrome (SILENCE-LQTS)

Titel: SGK1 inhibition shortens action potential duration in LQT3 mice and LQT2 rabbits via inhibition of late sodium current.
Auteur: Barbieri M, Casini S, Louradour J, de Waal TM, Sager PT, Das S, Wilde AAM, Odening KE, Remme CA
Magazine: Circulation

Titel: Genetic background determines the severity of age-dependent cardiac structural abnormalities and arrhythmia susceptibility in Scn5a-1798insD mice
Auteur: Marchal GA, Rivaud MR, Wolswinkel R, Basso C, van Veen TAB, Bezzina CR, Remme CA.
Magazine: Europace

Titel: Commemorating the 1924 Nobel Prize awarded to Willem Einthoven: a century of progress in electrocardiography and arrhythmia research
Auteur: Remme CA, Odening KE
Magazine: Europace

Titel: SCN5A-1795insD founder variant: a unique Dutch experience spanning 7 decades
Auteur: Proost VM, van den Berg MP, Remme CA, Wilde AAM.
Magazine: Neth Heart J
Begin- en eindpagina: 263-271

Titel: SGK1 inhibition normalizes action potential duration in transgenic LQT2 rabbits but not in LQT1, suggesting a novel gene-specific therapeutic approach in long QT syndrome
Auteur: Barbieri M, Louradour J, Alerni N, Giammarino L, Nimani S, Matas L, Horváth A., and Odening KE
Magazine: Cardiovascular Research

Titel: Therapeutic Efficacy of Mexiletine for Long QT Syndrome Type 2: Evidence From Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Transgenic Rabbits, and Patients
Auteur: Crotti L, et al
Magazine: Circulation
Begin- en eindpagina: 531-543

Titel: Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2
Auteur: Giannetti F, Barbieri M, Shiti A, Casini S, Sager PT, Das S, Pradhananga S, Srinivasan D, Nimani S, Alerni N, Louradour J, Mura M, Gnecchi M, Brink P, Zehender M, Koren G, Zaza A, Crotti L, Wilde AAM, Schwartz PJ, Remme CA, Gepstein L, Sala L, Odening KE.
Magazine: Europace

Titel: 25 years of basic and translational science in EP Europace: novel insights into arrhythmia mechanisms and therapeutic strategies
Auteur: Remme CA, Heijman J, Gomez AM, Zaza A, Odening KE
Magazine: Europace

Titel: Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2
Auteur: 11. Giannetti F, Barbieri M, Shiti A, Casini S, Sager PT, Das S, Pradhananga S, Srinivasan D, Nimani S, Alerni N, Louradour J, Mura M, Gnecchi M, Brink P, Zehender M, Koren G, Zaza A, Crotti L, Wilde AAM, Schwartz PJ, Remme CA, Gepstein L, Sala L, Odening KE.
Magazine: Europace

Titel: Samenvatting in lekentaal (gericht op patiënten en andere geïnteresseerden) van de wetenschappelijke publicatie van het consortium (doi: 10.1093/europace/euad094), gepubliceerd op de website van de European Reference Network for Rare and Low Prevalence Co
Link: https://guardheart.ern-net.eu/patients/laypersons-language/electrical-heart-diseases/serum-glucocorticoid-regulated-kinase-1-inhibition-as-a-novel-therapeutic-approach-in-long-qt-syndrome/)

Titel: SGK1 inhibition shortens action potential duration and exerts anti-arrhythmic effects in LQT3 mice and LQT2 rabbits by reducing enhanced late INa
Auteur: Casini S, Barbieri M, Louradour J, de Waal TM, Sager PT, Das S, Wilde AAM, Remme CA, Odening KE