From arrhythmia initiation to progression: uncovering the molecular mechanisms stabilizing cardiac arrhythmias using a computational-experimental approach

Titel: Mind the gap: leak currents and induced pluripotentstem cell-derived cardiomyocytes in translational cardiac electrophysiology
Auteur: Heijman J, Christ T
Magazine: Europace

Titel: In silico analysis of the dynamic regulation of cardiac electrophysiology by K_v 11.1ion-channel trafficking
Auteur: Meier S, Grundland A, Dobrev D, Volders PGA, Heijman J
Magazine: J Physiol

Titel: CNP Promotes Antiarrhythmic Effects via Phosphodiesterase 2
Auteur: Cachorro E, Günscht M, Schubert M, Sadek MS, Siegert J, Dutt F, BauermeisterC, Quickert S, Berning H, Nowakowski F, Lämmle S, Firneburg R, Luo X, Künzel SR,Klapproth E, Mirtschink P, Mayr M, Dewenter M, Vettel C, Heijman J, Lorenz K,Guan K, El-Armouche A, Wagner M, Kämmerer S
Magazine: Circ Res

Titel: Electrophysiological and calcium-handling development during long-termculture of human-induced pluripotent stem cell-derived cardiomyocytes
Auteur: Seibertz F, Sutanto H, Dülk R, Pronto JRD, Springer R, Rapedius M, LiutkuteA, Ritter M, Jung P, Stelzer L, Hüsgen LM, Klopp M, Rubio T, Fakuade FE, MasonFE, Hartmann N, Pabel S, Streckfuss-Bömeke K, Cyganek L, Sossalla S, Heijman J,Voigt N
Magazine: Basic Res Cardiol

Titel: Why translation from basicdiscoveries to clinical applications is so difficult for atrial fibrillation andpossible approaches to improving it
Auteur: Nattel S, Sager PT, Hüser J, Heijman J, Dobrev D
Magazine: Cardiovasc Res
Begin- en eindpagina: 1616-1631

Titel: Cellular Mechanisms of the Anti-Arrhythmic Effect ofCardiac PDE2 Overexpression
Auteur: Wagner M, Sadek MS, Dybkova N, Mason FE, Klehr J, Firneburg R, Cachorro E,Richter K, Klapproth E, Kuenzel SR, Lorenz K, Heijman J, Dobrev D, El-ArmoucheA, Sossalla S, Kämmerer S
Magazine: Int J Mol Sci

Titel: Dual effects of the small-conductance Ca²⁺-activated K⁺ current on human atrial electrophysiology and Ca²⁺-driven arrhythmogenesis: an in silico study
Auteur: Herrera NT, Zhang X, Ni H, Maleckar MM, Heijman J, Dobrev D, Grandi E,Morotti S
Magazine: Am J Physiol Heart Circ Physiol

Titel: Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomainto Whole-Heart: Overview and Perspectives
Auteur: Colman MA, Alvarez-Lacalle E, Echebarria B, Sato D, Sutanto H, Heijman J
Magazine: Front Physiol

Titel: <i>Insilico</i> Identification of Disrupted Myocardial Calcium Homeostasis as Proarrhythmic Trigger in Arrhythmogenic Cardiomyopathy
Auteur: Lyon A, van Opbergen CJM, Delmar M, Heijman J, van Veen TAB
Magazine: Front Physiol

Titel: Recent Advances in Antiarrhythmic Drug Therapy
Auteur: Saljic A, Heijman J, Dobrev D
Magazine: Drugs

Titel: 25 years of basic andtranslational science in EP Europace: novel insights into arrhythmia mechanismsand therapeutic strategies
Auteur: Remme CA, Heijman J, Gomez AM, Zaza A, Odening KE
Magazine: Europace

Titel: Molecular determinants and therapeutic potential of focal ectopic activity: more than meets the Iti
Auteur: Heijman J, Dobrev D
Magazine: Eur Heart J

Titel: Commentary: EP-PINNs: Cardiac electrophysiologycharacterisation using physics-informed neural networks
Auteur: Meier S, Heijman J
Magazine: Front Cardiovasc Med

Titel: Stretching the limits of antiarrhythmic drugtherapy: The promise of small-conductance calcium-activated potassium channelblockers
Auteur: Heijman J, Rahm AK, Dobrev D
Magazine: Int J Cardiol Heart Vasc

Titel: Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation: what can we learn from computer models?
Auteur: Heijman J, Dobrev D
Magazine: J Physiol

Titel: Emerging Antiarrhythmic Drugs for AtrialFibrillation
Auteur: Saljic A, Heijman J, Dobrev D
Magazine: Int J Mol Sci

Titel: Computationalmodels of atrial fibrillation: achievements, challenges, and perspectives forimproving clinical care
Auteur: Heijman J, Sutanto H, Crijns HJGM, Nattel S, Trayanova NA
Magazine: Cardiovasc Res

Titel: The Atrium in AtrialFibrillation - A Clinical Review on How to Manage Atrial Fibrotic Substrates
Auteur: Cunha PS, Laranjo S, Heijman J, Oliveira MM
Magazine: Front Cardiovasc Med

Titel: Enhanced Ca²⁺-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation
Auteur: Heijman J, Zhou X, Morotti S, Molina CE, Abu-Taha IH, Tekook M, Jespersen T,Zhang Y, Dobrev S, Milting H, Gummert J, Karck M, Kamler M, El-Armouche A,Saljic A, Grandi E, Nattel S, Dobrev D
Magazine: Circ Res

Titel: P2X7 receptors: central drivers of the neuro-cardiac link between atrial fibrillation and depression?
Auteur: Saljic A, Heijman J
Magazine: Europace