A Tissue-specific view on Sugar metabolism – creating the basis for high-precision sugar therapies
Suikermetabolisme is essentieel in ons hele lichaam. Toch verlopen de processen in verschillende weefsels anders. Waarom is dat zo? De onderzoekers zullen het volledige suikermetabolisme bestuderen in spier- en hersenmodellen van kinderen die ziek zijn door een fout in dit proces. Met de uitkomsten kunnen we hen beter behandelen.
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Titel: N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function
Magazine: Science Advances
Magazine: Science Advances
Titel: Sialic acid biosynthesis pathway blockade disturbs neuronal network formation in human iPSC-derived excitatory neurons
Magazine: Journal of Neurochemistry
Magazine: Journal of Neurochemistry
Titel: Oral sialic acid supplementation in NANS-CDG: Results of a single center, open-label, observational pilot study
Magazine: Journal of inherited Metabolic Disease
Magazine: Journal of inherited Metabolic Disease
Titel: Isotopic Tracing of Nucleotide Sugar Metabolism in Human Pluripotent Stem Cells
Magazine: Cells
Magazine: Cells
Titel: A tissue-specific view on sialic acid metabolism
Auteur: DJ Lefeber
Auteur: DJ Lefeber
Titel: A tissue-specific view on sugar metabolism
Auteur: DJ Lefeber
Auteur: DJ Lefeber
Titel: Cell-specific mechanisms in sialic acid metabolism
Auteur: DJ Lefeber
Auteur: DJ Lefeber
Titel: Congenital Disorders of Glycosylation (CDG), Diagnostic challenges solved by glycoproteomics
Auteur: DJ Lefeber
Auteur: DJ Lefeber