Through the looking-glass: an in-depth look at the role of inflammation in early cellular reprogramming in bone marrow fibrosis
Beenmergfibrose is een aandoening waarbij normaal beenmergweefsel geleidelijk wordt vervangen door littekenweefsel, wat leidt tot beenmergfalen en overlijden. Recente data suggereren dat ontsteking een grote rol speelt in het ontstaan van beenmergfibrose, maar de mechanismen hiervan blijven onbekend.
Dit project focust zich op het aanpakken van ontsteking als nieuwe behandelingsmethode.
Producten
Titel: Physically interacting cell sequencing in bone marrow fibrosis reveals distinct cellular niches
Auteur: Hélène F.E. Gleitz, James S. Nagai, Mayra Ruiz, Stijn Fuchs, Inge Snoeren, Aurélie Boeree, Giulia Cesaro, Rafael Kramann, Ivan Costa, Rebekka K. Schneider
Auteur: Hélène F.E. Gleitz, James S. Nagai, Mayra Ruiz, Stijn Fuchs, Inge Snoeren, Aurélie Boeree, Giulia Cesaro, Rafael Kramann, Ivan Costa, Rebekka K. Schneider
Titel: S205: INHIBITING THE ALARMIN-DRIVEN HEMATOPOIESIS-STROMAL CELLS CROSSTALK IN PRIMARY MYELOFIBROSIS AMELIORATES BONE MARROW FIBROSIS
Auteur: Gleitz, Hélène1; Snoeren, Inge1; Fuchs, Stijn1; Nagai, James2; Dugourd, Aurélien3; Boys, Charlotte3; Klöker, Vanessa2; Pritchard, Jessica1; Bindels, Eric5; Te Boekhorst, Peter André Willem5; Crysandt, Martina6; Saez-Rodriguez, Julio3; Vogl, Thomas7; Kramann, Rafael8; Costa, Ivan2; Schneider, Rebekka1
Link: https://journals.lww.com/hemasphere/fulltext/2023/08003/s205__inhibiting_the_alarmin_driven.107.aspx
Auteur: Gleitz, Hélène1; Snoeren, Inge1; Fuchs, Stijn1; Nagai, James2; Dugourd, Aurélien3; Boys, Charlotte3; Klöker, Vanessa2; Pritchard, Jessica1; Bindels, Eric5; Te Boekhorst, Peter André Willem5; Crysandt, Martina6; Saez-Rodriguez, Julio3; Vogl, Thomas7; Kramann, Rafael8; Costa, Ivan2; Schneider, Rebekka1
Link: https://journals.lww.com/hemasphere/fulltext/2023/08003/s205__inhibiting_the_alarmin_driven.107.aspx
Titel: Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation
Auteur: Stijn N R Fuchs 1 2, Ursula S A Stalmann 1 2, Inge A M Snoeren 1 2, Eric Bindels 3, Stephani Schmitz 1 2, Bella Banjanin 1 2, Remco M Hoogenboezem 3, Stanley van Herk 3, Mohamed Saad 4, Wencke Walter 5, Torsten Haferlach 5, Lancelot Seillier 6 7, Julio Saez-Rodriguez 8, Aurélien J F Dugourd 8, Kjong-Van Lehmann 6 7, Yinon Ben-Neriah 9, Hélène F E Gleitz 1 2, Rebekka K Schneider 1 2 4
Magazine: Blood Advances
Link: https://ashpublications.org/bloodadvances/article/8/3/766/506731/Collaborative-effect-of-Csnk1a1-haploinsufficiency
Auteur: Stijn N R Fuchs 1 2, Ursula S A Stalmann 1 2, Inge A M Snoeren 1 2, Eric Bindels 3, Stephani Schmitz 1 2, Bella Banjanin 1 2, Remco M Hoogenboezem 3, Stanley van Herk 3, Mohamed Saad 4, Wencke Walter 5, Torsten Haferlach 5, Lancelot Seillier 6 7, Julio Saez-Rodriguez 8, Aurélien J F Dugourd 8, Kjong-Van Lehmann 6 7, Yinon Ben-Neriah 9, Hélène F E Gleitz 1 2, Rebekka K Schneider 1 2 4
Magazine: Blood Advances
Link: https://ashpublications.org/bloodadvances/article/8/3/766/506731/Collaborative-effect-of-Csnk1a1-haploinsufficiency
Titel: Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms
Auteur: Jessica E Pritchard 1, Juliette E Pearce 2, Inge A M Snoeren 3, Stijn N R Fuchs 3,...Ross L Levine 10, Ivan G Costa 5, Hélène F E Gleitz 3, Rafael Kramann 13, Rebekka K Schneider 14
Magazine: Cell Reports
Link: https://www.sciencedirect.com/science/article/pii/S2211124723016200?via%3Dihub
Auteur: Jessica E Pritchard 1, Juliette E Pearce 2, Inge A M Snoeren 3, Stijn N R Fuchs 3,...Ross L Levine 10, Ivan G Costa 5, Hélène F E Gleitz 3, Rafael Kramann 13, Rebekka K Schneider 14
Magazine: Cell Reports
Link: https://www.sciencedirect.com/science/article/pii/S2211124723016200?via%3Dihub
Titel: Inhibiting the alarmin-driven hematopoiesis-stromal cell crosstalk in primary myelofibrosis ameliorates bone marrow fibrosis
Auteur: Hélène F E Gleitz 1 2 3, Stijn N R Fuchs 1 2, Inge A M Snoeren 1 2, Charlotte Boys 4, James Nagai 5, Hector Tejeda-Mora 1 2, Vanessa Klöker 5, Jessica E Pritchard 1 2 3, Iris J Bakker 1, Marta Gargallo Garasa 1 2, Eric Bindels 6, Julio Saez-Rodriguez 4, Thomas Vogl 7, Rafael Kramann 8 9 10, Aurélien Dugourd 4, Ivan G Costa 5, Rebekka K Schneider 1 2 3
Magazine: Hemasphere
Link: https://onlinelibrary.wiley.com/doi/10.1002/hem3.70179
Auteur: Hélène F E Gleitz 1 2 3, Stijn N R Fuchs 1 2, Inge A M Snoeren 1 2, Charlotte Boys 4, James Nagai 5, Hector Tejeda-Mora 1 2, Vanessa Klöker 5, Jessica E Pritchard 1 2 3, Iris J Bakker 1, Marta Gargallo Garasa 1 2, Eric Bindels 6, Julio Saez-Rodriguez 4, Thomas Vogl 7, Rafael Kramann 8 9 10, Aurélien Dugourd 4, Ivan G Costa 5, Rebekka K Schneider 1 2 3
Magazine: Hemasphere
Link: https://onlinelibrary.wiley.com/doi/10.1002/hem3.70179
Titel: Biological drivers of clinical phenotype in myelofibrosis
Auteur: John Mascarenhas, Hélène F. E. Gleitz, Helen T. Chifotides, Claire N. Harrison, Srdan Verstovsek, Alessandro Maria Vannucchi, Raajit K. Rampal, Jean-Jacques Kiladjian, William Vainchenker, Ronald Hoffman, Rebekka K. Schneider & Alan F. List
Magazine: Leukemia
Link: https://www.nature.com/articles/s41375-022-01767-y
Auteur: John Mascarenhas, Hélène F. E. Gleitz, Helen T. Chifotides, Claire N. Harrison, Srdan Verstovsek, Alessandro Maria Vannucchi, Raajit K. Rampal, Jean-Jacques Kiladjian, William Vainchenker, Ronald Hoffman, Rebekka K. Schneider & Alan F. List
Magazine: Leukemia
Link: https://www.nature.com/articles/s41375-022-01767-y
Titel: Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion
Auteur: Ursula S A Stalmann 1 2, Fabio Ticconi 3, Inge A M Snoeren 1 2, Ronghui Li 3, Hélène F E Gleitz 1 2, Glenn S Cowley 4, Marie E McConkey 5, Aaron B Wong 6, Stephani Schmitz 1 2, Stijn N R Fuchs 1 2, Shubhankar Sood 7 8, Nils B Leimkühler 2, Sergio Martinez-Høyer 2, Bella Banjanin 1 2, David Root 4, Tim H Brümmendorf 9, Juliette E Pearce 10, Andreas Schuppert 11, Eric M J Bindels 12, Marieke A Essers 7 8, Dirk Heckl 13, Thomas Stiehl 14, Ivan G Costa 3, Benjamin L Ebert, Rebekka K Schneider
Magazine: Blood Advances
Link: https://ashpublications.org/bloodadvances/article/6/6/1780/483437/Genetic-barcoding-systematically-compares-genes-in
Auteur: Ursula S A Stalmann 1 2, Fabio Ticconi 3, Inge A M Snoeren 1 2, Ronghui Li 3, Hélène F E Gleitz 1 2, Glenn S Cowley 4, Marie E McConkey 5, Aaron B Wong 6, Stephani Schmitz 1 2, Stijn N R Fuchs 1 2, Shubhankar Sood 7 8, Nils B Leimkühler 2, Sergio Martinez-Høyer 2, Bella Banjanin 1 2, David Root 4, Tim H Brümmendorf 9, Juliette E Pearce 10, Andreas Schuppert 11, Eric M J Bindels 12, Marieke A Essers 7 8, Dirk Heckl 13, Thomas Stiehl 14, Ivan G Costa 3, Benjamin L Ebert, Rebekka K Schneider
Magazine: Blood Advances
Link: https://ashpublications.org/bloodadvances/article/6/6/1780/483437/Genetic-barcoding-systematically-compares-genes-in
Titel: Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion
Auteur: Ursula S. A. Stalmann, Fabio Ticconi, Inge A. M. Snoeren, Ronghui Li, Hélène F. E. Gleitz, Glenn S. Cowley, Marie E. McConkey, Aaron B. Wong, Stephani Schmitz, Stijn N. R. Fuchs, Shubhankar Sood, Nils B. Leimkühler, Sergio Martinez-Høyer, Bella Banjanin, David Root, Tim H. Brümmendorf, Juliette E. Pearce, Andreas Schuppert, Eric M. J. Bindels, Marieke A. Essers, Dirk Heckl, Thomas Stiehl, Ivan G. Costa, Benjamin L. Ebert, Rebekka K. Schneider
Magazine: Blood Advances
Link: https://ashpublications.org/bloodadvances/article/6/6/1780/483437/Genetic-barcoding-systematically-compares-genes-in
Auteur: Ursula S. A. Stalmann, Fabio Ticconi, Inge A. M. Snoeren, Ronghui Li, Hélène F. E. Gleitz, Glenn S. Cowley, Marie E. McConkey, Aaron B. Wong, Stephani Schmitz, Stijn N. R. Fuchs, Shubhankar Sood, Nils B. Leimkühler, Sergio Martinez-Høyer, Bella Banjanin, David Root, Tim H. Brümmendorf, Juliette E. Pearce, Andreas Schuppert, Eric M. J. Bindels, Marieke A. Essers, Dirk Heckl, Thomas Stiehl, Ivan G. Costa, Benjamin L. Ebert, Rebekka K. Schneider
Magazine: Blood Advances
Link: https://ashpublications.org/bloodadvances/article/6/6/1780/483437/Genetic-barcoding-systematically-compares-genes-in