Alpha-Synuclein OMICS to identify Drug-targets (SynOD)

Various neurodegenerative diseases, such as Parkinson's and multiple system atrophy, are caused by the accumulation of the alpha-synuclein protein in brain cells. To develop drugs for these diseases, a deeper understanding of the molecular causes and consequences of protein accumulation is needed.

Objective

The consortium has biological datasets in patient tissues and cell lines, along with results of experiments on the effect of drugs on cell survival with this protein. Through advanced analysis of these datasets, we aim to identify molecular pathways for these diseases and related medications.

Approach

The therapeutic relevance of the discovered drugs will be further investigated in vitro. The obtained biological and chemical insights will bring the development of therapies to cure these diseases closer.

Expected Results

Ultimately, this will lead to lower social and economic costs associated with these diseases in an aging population.