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Antimicrobial Resistance Manure Intervention Strategies - ARMIS

More and more animal manure is being processed before it is applied to land.

Aim

In ARMIS, RIVM together with WUR and international partners investigated the extent to which manure processing can reduce antibiotic resistance. Measurements were conducted in Canada, Romania, Germany and the Netherlands.

Results

Composting, fermentation, biological and large-scale treatment can reduce the amount of resistant bacteria. However, resistant bacteria, such as MRSA and ESBL E. coli, are still found in the end products. Transmission of resistance to other bacteria may also potentially occur during manure processing, but the frequency is lower after manure processing. Neighbours of manure processing installations in the Netherlands are more often worried about these installations than the general population, but do not show more stress. Participation in the placement of these installations is associated with fewer worries - an indication of the importance of communication with local residents.

Products

Title: Genomic plasticity and adaptive capacity of the quaternary alkyl-ammonium compound and copper tolerant Acinetobacter bohemicus strain QAC-21b isolated from pig manure
Author: Pulami D, Schwabe L, Blom J, Schwengers O, Wilharm G, Kämpfer P, Glaeser SP.
Magazine: Antonie van Leeuwenhoek
Link: https://link.springer.com/article/10.1007/s10482-022-01805-w
Title: High diversity of the emerging pathogen Acinetobacter baumannii and other Acinetobacter spp. in raw manure, biogas plants digestates, and rural and urban wastewater treatment plants with system specific antimicrobial resistance profile
Author: Pulami D, Kämpfer P, Glaeser SP.
Magazine: Science of The Total Environment
Link: https://www.sciencedirect.com/science/article/abs/pii/S0048969722072825
Title: Characterization of Escherichia coli and Other Enterobacterales Resistant to Extended-Spectrum Cephalosporins Isolated from Dairy Manure in Ontario, Canada
Author: Rebecca E.V. Anderson, Gabhan Chalmers, Roger Murray, Laura Mataseje, David L. Pearl, Michael Mulvey, Edward Topp , Patrick Boerlin
Magazine: Antimicrobial Chemotherapy
Link: https://journals.asm.org/doi/epub/10.1128/aem.01869-22
Title: Insights into the impact of manure on the environmental antibiotic residues and resistance pool
Author: Marutescu LG, Jaga M, Postolache C, Barbuceanu F, Milita NM, Romascu LM, Schmitt H, de Roda Husman AM, Sefeedpari P, Glaeser S, Kämpfer P.
Magazine: Frontiers in Microbiology
Start- and endpage: 965132-
Link: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.965132/full
Title: On-farm anaerobic digestion of dairy manure reduces the abundance of antibiotic resistance-associated gene targets and the potential for plasmid transfer
Author: Tran TT, Scott A, Tien YC, Murray R, Boerlin P, Pearl DL,Liu K, Robertson J, Nash JH, Topp E.
Magazine: Applied and Environmental Microbiology
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC8231723/
Title: Potential selection and maintenance of manure-originated multi-drug resistant plasmids at sub-clinical concentrations for tetracycline family antibiotics
Author: Tran TT, Cole M, Tomas E, Scott A, Topp E.
Magazine: Canadian Journal of Microbiology
Start- and endpage: 339-350
Link: https://cdnsciencepub.com/doi/abs/10.1139/cjm-2022-0240
Title: Characterization of Proteus mirabilis and associated plasmids isolated from anaerobic dairy cattle manure digesters
Author: Chalmers G, Anderson RE, Murray R, Topp E, Boerlin P. C.
Magazine: PLoS One
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0289703

Quick links

  • Antibiotics
  • Antibiotic resistance
  • Antimicrobial resistance
  • International
  • Resistance

    • Features

    • Project number:
      549003003
    • Duration: 100%
      2018
      2023
    • Part of programme:
    • Related funding round:
      5th JTC Interventions
    • Project lead and secretary:
      dr. H. Schmitt
    • Responsible organisation:
      Rijksinstituut voor Volksgezondheid en Milieu