Apoptotic neutrophils in atherosclerosis: decision shapers and therapeutic targets
Slagaderverkalking, ook wel atherosclerose genoemd is de onderliggende oorzaak van veel hart- en vaatziekten, zoals een beroerte of hartinfarct. Ontsteking speelt een belangrijke rol in atherosclerose. Dit onderzoek heeft aangetoond dat de neutrofiel, een kortlevende, maar zeer efficiënte ontstekingscel belangrijk is in het ontstaan van slagaderverkalking. Verder hebben we kunnen aantonen dat vooral de stervende neutrofiel atherosclerose verergerd. Hiertoe hebben wij cel-dood pathways van de neutrofiel in de verschillende stadia van atherosclerose ontrafelt, en aangetoond dat remming van ontsteking eiwitten die door dode neutrofielen geactiveerd worden slagaderverkalking vermindert.
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Titel: Myeloid cells in traffic.
Auteur: Soehnlein, O
Magazine: Journal of Innate Immunity
Auteur: Soehnlein, O
Magazine: Journal of Innate Immunity
Titel: Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis.
Auteur: Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG, Fässler R, Deutsch U, Kupatt C.
Magazine: Journal of Clinical Investigation
Auteur: Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG, Fässler R, Deutsch U, Kupatt C.
Magazine: Journal of Clinical Investigation
Titel: Resolution of inflammation: an integrated view.
Auteur: Ortega-Gómez A, Perretti M, Soehnlein O.
Magazine: EMBO Molecular Medicine
Auteur: Ortega-Gómez A, Perretti M, Soehnlein O.
Magazine: EMBO Molecular Medicine
Titel: Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.
Auteur: Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele ST, Hamulyák K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EA, Spronk HM, ten Cate H.
Magazine: PLoS ONE
Auteur: Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele ST, Hamulyák K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EA, Spronk HM, ten Cate H.
Magazine: PLoS ONE
Titel: Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice.
Auteur: Lenglet S, Thomas A, Soehnlein O, Montecucco F, Burger F, Pelli G, Galan K, Cravatt B, Staub C, Steffens S.
Magazine: Arteriosclerosis, Thrombosis and Vascular Biology
Auteur: Lenglet S, Thomas A, Soehnlein O, Montecucco F, Burger F, Pelli G, Galan K, Cravatt B, Staub C, Steffens S.
Magazine: Arteriosclerosis, Thrombosis and Vascular Biology
Titel: Role of the Cathelicidin-Related Antimicrobial Peptide in Inflammation and Mortality in a Mouse Model of Bacterial Meningitis.
Auteur: Merres J, Höss J, Albrecht LJ, Kress E, Soehnlein O, Jansen S, Pufe T, Tauber SC, Brandenburg LO.
Magazine: Journal of Innate Immunity
Auteur: Merres J, Höss J, Albrecht LJ, Kress E, Soehnlein O, Jansen S, Pufe T, Tauber SC, Brandenburg LO.
Magazine: Journal of Innate Immunity
Titel: Footprints of neutrophil extracellular traps as predictors of cardiovascular risk.
Auteur: Döring Y, Weber C, Soehnlein O.
Magazine: Arteriosclerosis, Thrombosis and Vascular Biology
Auteur: Döring Y, Weber C, Soehnlein O.
Magazine: Arteriosclerosis, Thrombosis and Vascular Biology
Titel: CCR5 and FPR1 Mediate Neutrophil Recruitment in Endotoxin-Induced Lung Injury.
Auteur: Grommes J, Drechsler M, Soehnlein O.
Magazine: Journal of Innate Immunity
Auteur: Grommes J, Drechsler M, Soehnlein O.
Magazine: Journal of Innate Immunity
Titel: Neutrophil-derived cathelicidin promotes adhesion of classical monocytes.
Auteur: Wantha S, Alard JE, Megens RT, van der Does AM, Döring Y, Drechsler M, Pham CT, Wang MW, Wang JM, Gallo RL, von Hundelshausen P, Lindbom L, Hackeng T, Weber C, Soehnlein O.
Magazine: Circulation Research
Auteur: Wantha S, Alard JE, Megens RT, van der Does AM, Döring Y, Drechsler M, Pham CT, Wang MW, Wang JM, Gallo RL, von Hundelshausen P, Lindbom L, Hackeng T, Weber C, Soehnlein O.
Magazine: Circulation Research
Titel: Hypercholesterolemia links hematopoiesis with atherosclerosis
Auteur: Soehnlein O, Swirski FK.
Magazine: Trends in Endocrinology and Metabolism
Auteur: Soehnlein O, Swirski FK.
Magazine: Trends in Endocrinology and Metabolism
Titel: The complexity of arterial classical monocyte recruitment.
Auteur: Drechsler M, Soehnlein O.
Magazine: Journal of Innate Immunity
Auteur: Drechsler M, Soehnlein O.
Magazine: Journal of Innate Immunity