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Bone augmentation with autologous adipose tissue-derived mesenchymal stem cells, BMP-2, and calcium phosphate carrier in the human maxillary sinus floor elevation model

Het plaatsen van tandheelkundige implantaten gaat veelal gepaard met veel pijn en weefselbeschadiging. Dit wordt veroorzaakt doordat er vaak onvoldoende kaakbot aanwezig is.  Hierdoor is men genoodzaakt om de bodem van de sinus maxillaris (een holte in de bovenkaak) op te hogen met bot uit de bekkenkam of botvervanginsmateriaal zodat het plaatsen van implantaten mogelijk is. Het nadeel van het gebruik van kunstmatig botvervangingsmateriaal is dat het minder botgroei oplevert dan bot uit de bekkenkam. In deze studie wordt een nieuwe klinische methode getest waarbij lichaamseigen vetstamcellen gecombineerd worden met botvervangingsmateriaal onder stimulatie van BMP-2 en wordt de groei van bot bevorderd.

Producten

Titel: Helpen vetstamcellen tandwortelimplantaten?
Link: http://www.fbw.vu.nl/nl/onderzoek/vufit-nl/vetstamcellen-tandwortelimplantaten.asp
Titel: Studiemiddag Patiëntenparticipatie in Wetenschappelijk Onderzoek
Titel: Oral Regenerative Medicine.
Titel: Osteogenic differentiation strategies for adipose-derived mesenchymal stem cells.
Titel: Informative meeting "Stem cell lift project" Oral and Maxillofacial Surgery – Orthopedic Surgery for OR-personnel VU University Medical Center, Amsterdam, NL, Nov 17, 2010.
Titel: European Orthopaedic Research Society 20th Annual Meeting.
Titel: "Kapot bot? Liposuctie biedt uitkomst"
Titel: Short (15 minutes) BMP-2 treatment stimulates osteogenic differentiation of human adipose stem cells seeded on calcium phophates scaffolds in vitro.
Auteur: Overman JR, Farré-Guasch E, Helder MN, Ten Bruggenkate CM, Schulten EAJM, Klein-Nulend J
Magazine: Tissue Engineering Part A
Titel: Bone augmentation with adipose tissue-derived mesenchymal stem cells, BMP-2, and calcium phosphate carriers in the human maxillary sinus floor elevation model.
Titel: Wnt5a induces osteogenic differentiation of human adipose stem cells via Rho-associated kinase ROCK.
Auteur: Santos A, Bakker AD, de Blieck-Hogervorst JMA, Klein-Nulend J.
Magazine: Cytotherapy
Titel: Mechanical loading and how it affects bone cells.
Titel: Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes.
Auteur: Santos A, Bakker AD, Willems HM, Bravenboer N, Bronckers AL, Klein-Nulend J.
Magazine: Calcified Tissue International
Titel: Reaming debris as a novel source of autologous bone to enhance healing of bone defects.
Auteur: Bakker AD, Kroeze RJ, Korstjens C, de Kleine RH, Frölke JP, Klein-Nulend J.
Magazine: Journal of Biomedical Materials Research Part A
Titel: Bone augmentation with adipose tissue-derived mesenchymal stem cells, BMP-2, and calcium phosphate carriers in the human maxillary sinus floor elevation model.
Titel: Human dental pulp cells exhibit bone cell-like responsiveness to fluid shear stress.
Auteur: Kraft DC, Bindslev DA, Melsen B, Klein-Nulend J.
Magazine: Cytotherapy
Titel: The use of Straumann® Bone Ceramic in maxillary sinus floor elevation procedure: A clinical, radiological, histological and histomorphometric evaluation with 6 months healing time.
Auteur: Frenken JWFH, Bouwman WF, Bravenboer N, Zijderveld SA, Schulten EAJM, Ten Bruggenkate CM.
Magazine: Clinical Oral Implants Research
Titel: Human platelet lysate as a fetal bovine serum substitute improves human adipose derived stem cell culture for cardiac repair.
Titel: Osteogenic gene expression in BMP-2-induced human adipose stem cells seeded on biphasic calcium phosphate.
Titel: Bone augmentation with adipose tissue-derived mesenchymal stem cells and calcium phosphate carriers in the human maxillary sinus floor elevation model.
Titel: Osteogenic differentiation of BMP-2-induced human adipose stem cells seeded on biphasic calcium phosphate and beta-tricalcium phosphate carriers.
Titel: Mechanosensation and transduction in osteocytes.
Auteur: Klein-Nulend J, Bakker AD, Bacabac RG, Vatsa A, Weinbaum S.
Magazine: Bone
Titel: One-step surgical procedure for the treatment of osteochondral defects with adipose derived stem cells in a caprine knee defect: a pilot study.
Titel: Rapid attachment of adipose stromal cells on resorbable polymeric scaffolds facilitates the one-step surgical procedure for cartilage and bone tissue engineering purposes.
Auteur: Jurgens WJ, Kroeze RJ, Bank RA, Ritt MJPF, Helder MN.
Magazine: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Titel: Mechanical loading and how it affects bone cells: The role of the osteocyte cytoskeleton in maintaining our skeleton.
Auteur: Klein-Nulend J, Bacabac RG, Bakker AD: Mechanical loading and how it affects bone cells: The role of the osteocyte cytoskeleton in maintaining our skeleton.
Magazine: European Cells and Materials
Titel: Buccal fat pad, an oral access source of human adipose stem cells with potential for osteochondral tissue engineering: an in vitro study.
Auteur: Farré-Guasch E, Martí-Pagè C, Hernádez-Alfaro F, Klein-Nulend J, Casals N.
Magazine: Tissue Engineering Part C: Methods
Titel: Both pre-compressed and non-pre-compressed grafting material from the iliac crest successful in maxillary sinus floor elevation surgery.
Titel: Human platelet lysate improves human adipose derived stem cell culture.
Titel: Human maxillary sinus floor elevation using β-tricalcium phosphate alone or in combination with a bioabsorbable collagen membrane.
Titel: Treatment of goat osteochondral knee defects with adipose derived stem cells using a one-step surgical procedure.
Titel: Bone augmentation with adipose stem cells and calcium phosphate carriers for human maxillary sinus floor elevation: an ongoing phase I clinical trial.
Titel: A 5-year prospective multicenter study of early loaded titanium implants with a sandblasted and acid-etched surface.
Auteur: Cochran DL, Jackson JM, Bernard JP, ten Bruggenkate CM, Buser D, Taylor TD, Weingart D, Schoolfield JD, Jones AA, Oates TW Jr.
Magazine: International Journal of Oral and Maxillofacial Implants
Titel: Human maxillary sinus floor elevation as a model for bone regeneration enabling the application of one-step surgical procedures.
Auteur: Farré-Guasch E, Prins HJ, Overman JR, Ten Bruggenkate CM, Schulten EAJM, Helder MN, Klein-Nulend J.
Magazine: Tissue Engineering Part C: Methods
Titel: Osteogenic differentiation of BMP-2-induced human adipose stem cells seeded on biphasic calcium phosphate and beta-tricalcium phosphate carriers.
Titel: Bone adaptation and regeneration
Auteur: Klein-Nulend J, Bacabac RG.
Magazine: International Journal of Modern Physics
Titel: Collagen type II enhances chondrogenesis in adipose tissue-derived stem cells by affecting cell shape.
Auteur: Lu Z, Zandieh-Doulabi B, Bank RA, Helder MN.
Magazine: Tissue Engineering
Titel: Mechanosensitivity of dental pulp stem cells is related to their osteogenic maturity.
Auteur: Kraft DC, Bindslev DA, Melsen B, Abdallah BM,Kassem M, Klein-Nulend J.
Magazine: European Journal of Oral Sciences
Titel: Platelet lysate as a fetal bovine serum substitute improves human adipose derived stromal cell culture for future cardiac repair applications.
Auteur: Naaijkens BA, Niessen HWM, Prins HJ, Krijnen PAJ, Kokhuis TJA, de Jong N, van Hinsbergh VWM, Musters RJP, Kamp O, Helder MN, van Dijk A, Juffermans LJM.
Magazine: Cell tissue research
Titel: Adipose stem cells for skeletal tissue engineering
Titel: A phase I clinical trial for maxillary bone augmentation with adipose stem cells and calcium phosphate scaffolds.
Titel: Over osteocyten, de klinische relevantie.
Titel: Development, validation, and clinical implementation of a novel one-step surgical concept for adipose stem cell-mediated bone tissue engineering.
Titel: Tissue engineering / regenerative medicine in Amsterdam, The Netherlands.
Titel: Translational research and clinical implementation of adipose stem cells for skeletal tissue engineering.
Titel: Sinus lifting.
Titel: Stem cells in regenerative medicine, application in oral and maxillofacial surgery
Titel: Adipose stem cells and bone/cartilage regeneration.
Titel: Osteogenic differentiation of BMP-2 induced human adipose stem cells seeded on biphasic calcium phosphate and β-tricalcium phosphate scaffolds.
Titel: (Vet)stamcel-theapie binnen het VUMC: Utopie of binnenkort realiteit? Symposium Open Chirurgische dagen, VUMC, Amsterdam, NL, May 14-15, 2009.
Titel: Cartilage regeneration.
Titel: The edentuleous upper jaw; 2) The edentulous posterior maxilla: different aspects of sinus floor elevation; 3) Pre-implant surgery in the esthetic area.
Titel: Reconstructieve oral and maxillofacial surgery and implantology.
Titel: Intercellular communication between osteocytes and stem cells: implications for bone tissue engineering.
Titel: Application of implants in oral and maxillofacial surgery: surgical and prosthetical aspects.
Titel: Pre-implant surgery.
Titel: Bone adaptation and regeneration.
Titel: Sinusbodenelevation.
Titel: Bone augmentation with adipose stem cells and calcium phosphate carriers for human maxillary sinus floor elevation: update on a phase I clinical trial.
Titel: Stem cells from adipose tissue: Applications in skeletal tissue engineering.
Titel: Stemcell Lift Project.
Titel: How our bones sense mechanical loading and transduce this information at the cellular level.
Titel: Stress effects on bone cells.
Titel: Sinus floor elevation
Titel: Mechanical loading and how it affects bone cells.
Titel: Bone substitutes.
Titel: Bone or bone substitutes.
Titel: Short (15 Minutes) BMP-2 Treatment Stimulates Osteogenic Differentiation of Human Adipose Stem Cells Seeded on Calcium Phosphate Scaffolds.
Titel: Bone adaptation and regeneration – new developments.
Titel: From bench to bedside: adipose stem cells for tissue engineering.
Titel: Bone regeneration in the maxillofacial region.
Titel: Short (15 minutes) treatment stimulates osteogenic differentiation of human adipose stem cells seeded on calcium phosphate scaffolds in vitro.
Titel: Jaw reconstructions and implants.
Titel: Mechanosensation by osteocytes and bone remodeling.
Titel: SAC classification.
Titel: Komplikationen und Schwierige Situationen.
Titel: Van der Kwast lecture.
Titel: Pro-inflammatory cytokines stimulate expression of trophic factors and markers for proliferation and osteogenic differentiation by adipose stem cells.
Titel: Orthopedic surgery and tissue engineering / regenerative medicine.
Titel: Bone augmentation with autologous adipose stem cells, BMP-2, and calcium phosphate carrier in the human maxillary sinus floor elevation model.
Titel: Role of Wnt signalling in bone remodeling.
Titel: Botregeneratie.
Titel: Review of physical approaches of bone repair including ultrasound.
Titel: Translational research between dentistry & orthopaedics.
Titel: Sinusbodemelevatie met calciumfosfaten en vetstamcellen in één chirurgische procedure: een fase I studie.
Titel: Over meesters en gezellen.
Titel: Bone augmentation with adipose stem cells and calcium phosphate carriers for human maxillary sinus floor elevation: an ongoing phase I clinical trial.
Titel: Het Tandheelkundig Jaar 2011.
Auteur: Schulten EAJM, Forouzanfar T.
Titel: Het Tandheelkundig Jaar 2012.
Auteur: Schulten EAJM, ten Bruggenkate CM, Goené RJ.
Titel: Mineralized tissues in oral and craniofacial scienc
Auteur: Prins HJ, Bronckers ALJJ, Klein-Nulend J.

Kenmerken

  • Projectnummer:
    116001009
  • Looptijd: 100%
    Looptijd: 100 %
    2010
    2013
  • Gerelateerde programma's:
  • Gerelateerde subsidieronde:
  • Projectleider en penvoerder:
    Prof. dr. J. Klein Nulend
  • Verantwoordelijke organisatie:
    Academisch Centrum Tandheelkunde Amsterdam