Cancer-associated fibroblasts in oncolytic virus therapy: innocent bystanders or key players?
Oncolytische virustherapie is een recente veelbelovende anti-kanker aanpak, waarbij virussen specifiek kankercellen vernietigen en normale cellen onaangetast laten. Echter bevat een tumor niet alleen kankercellen, maar daarnaast tot 90% bindweefsel, voornamelijk gevormd door kanker-geassocieerde fibroblasten.
Dit project bestudeert hoe deze fibroblasten de effectiviteit van oncolytische virustherapie beïnvloeden.
Producten
Titel: Biomarker Screen for Efficacy of Oncolytic Virotherapy in Patient-derived Pancreatic Cancer Cultures
Auteur: Schäfer TE, Knol LI, Haas FV, Hartley A, Pernickel SCS, Jády A, Finkbeiner MSC, Achberger J, Arelaki S, Modic Z, Schröer K, Zhang W, Schmidt B, Schuster P, Haferkamp S, Doerner J, Gebauer F, Ackermann M, Kvasnicka HM, Kulkarni A, Bots STF, Kemp V, Hawinkels LJAC, Poetsch AR, Hoeben RC, Ehrhardt A, Marchini A, Ungerechts G, Ball CR, Engeland CE
Magazine: eBioMedicine
Begin- en eindpagina: 105219-
Link: https://www.sciencedirect.com/science/article/pii/S2352396424002548?via%3Dihub
Auteur: Schäfer TE, Knol LI, Haas FV, Hartley A, Pernickel SCS, Jády A, Finkbeiner MSC, Achberger J, Arelaki S, Modic Z, Schröer K, Zhang W, Schmidt B, Schuster P, Haferkamp S, Doerner J, Gebauer F, Ackermann M, Kvasnicka HM, Kulkarni A, Bots STF, Kemp V, Hawinkels LJAC, Poetsch AR, Hoeben RC, Ehrhardt A, Marchini A, Ungerechts G, Ball CR, Engeland CE
Magazine: eBioMedicine
Begin- en eindpagina: 105219-
Link: https://www.sciencedirect.com/science/article/pii/S2352396424002548?via%3Dihub
Titel: Evaluation of the Gorilla-Derived Oncolytic Adenovirus AdV-lumc007 ‘GoraVir’ for the Treatment of Pancreatic Ductal Adenocarcinoma
Auteur: Bots STF, Harryvan TJ, Groeneveldt C, Kinderman P, Kemp V, van Montfoort N, and Hoeben RC
Magazine: Molecular Oncology
Begin- en eindpagina: 1245-1258
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC8972008/
Auteur: Bots STF, Harryvan TJ, Groeneveldt C, Kinderman P, Kemp V, van Montfoort N, and Hoeben RC
Magazine: Molecular Oncology
Begin- en eindpagina: 1245-1258
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC8972008/
Titel: Gastrointestinal cancer-associated fibroblasts expressing Junctional Adhesion Molecule-A are amenable to infection by oncolytic reovirus
Auteur: Harryvan TJ, Golo M, Dam N, Schoonderwoerd MJA, Farshadi EA, Hornsveld M, Hoeben RC, Hawinkels LJAC, Kemp V.
Magazine: Cancer Gene Therapy
Begin- en eindpagina: 1918-1929
Link: https://www.nature.com/articles/s41417-022-00507-9
Auteur: Harryvan TJ, Golo M, Dam N, Schoonderwoerd MJA, Farshadi EA, Hornsveld M, Hoeben RC, Hawinkels LJAC, Kemp V.
Magazine: Cancer Gene Therapy
Begin- en eindpagina: 1918-1929
Link: https://www.nature.com/articles/s41417-022-00507-9
Titel: ZEB1, a novel regulator of Junctional Adhesion Molecule A, impacts sensitivity of pancreatic CAFs to oncolytic reovirus
Auteur: Dam N, Harryvan TJ, Dang H, Ioannidis G, Schmierer B, Hawinkels LJAC, Kemp V
Magazine: Molecular Therapy Oncology
Begin- en eindpagina: 201071-
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC12617759/
Auteur: Dam N, Harryvan TJ, Dang H, Ioannidis G, Schmierer B, Hawinkels LJAC, Kemp V
Magazine: Molecular Therapy Oncology
Begin- en eindpagina: 201071-
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC12617759/