Characterization of the physiological roles of Multidrug Resistance Protein (MRP)1-6 by in vivo screening for their substrates

Titel: Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol
Auteur: van de Wetering K, Burkon A, Feddema W, Bot A, de Jonge H, Somoza V, Borst P.
Magazine: Molecular Pharmacology

Titel: Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.
Auteur: Vlaming MLH, Pala Z, Van Esch A, Wagenaar E, Van Tellingen O, De Waart DR, Oude Elferink RPJ, Van de Wetering K, Schinkel AH.
Magazine: Clinical Cancer Research

Titel: Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo.
Auteur: Van de Wetering K, Feddema W, Helms JB, Brouwers JF, Borst P.
Magazine: Gastroenterology

Titel: Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays
Auteur: Petra Krumpochova, Sunny Sapthu, Jos F Brouwers, Marcel de Haas, Ric de Vos, Piet Borst and Koen van de Wetering.
Magazine: FASEB Journal

Titel: Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo
Auteur: Vlaming ML, Pala Z, van Esch A, Wagenaar E, de Waart DR, van de Wetering K, van der Kruijssen CM, Oude Elferink RP, van Tellingen O, Schinkel AH
Magazine: Clinical Cancer Research

Titel: Unimpaired immune functions in the absence of Mrp4 (Abcc4)
Auteur: van de Ven R, de groot J, Reurs AW, Wijnands PG, van de Wetering K, Schuetz JD, de Gruijl TD, Scheper RJ, Scheffer GL.
Magazine: Immunology Letters

Titel: Transport of diclofenac by BCRP (ABCG2) and sitmulation of MRP2-(ABCC2-)mediated drug transport by diclofenac and benzbromarone.
Auteur: Lagas JS, Van der Kruissen CM, Van de Wetering K, Beijnen JH, Schinkel AH.
Magazine: Drug Metabolism and Disposition

Titel: Does the absence of ABCC6 (Multidrug Resistance Protein 6) in patients with Pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery?
Auteur: Borst P, van de Wetering K, Schlingemann R.
Magazine: Cell Cycle

Titel: ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: Relevance to pathomechanisms of pseudoxanthoma elasticum
Auteur: Fulop,K.; Jiang,Q.; van de Wetering,K..; Pomozi,V.; Szabo,P.T.; Aranyi,T.; Sarkadi,B.; Borst,P.; Uitto,J.; Varadi,A.
Magazine: Biochemical Biophysical Research Communications

Titel: Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2).
Auteur: Zimmerman C, van de Wetering K, van de Steeg E, Wagenaar E, Vens C, Schinkel A.
Magazine: Drug Metabolism and Disposition

Titel: Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin.
Auteur: Beedholm-Ebsen R, Van de Wetering K, Hardlei T, Nexo E, Borst P, Moestrup SK
Magazine: Blood

Titel: ABCG2 functions as a general phytoestrogen sulfate transporter in vivo
Auteur: Koen van de Wetering and Sunny Sapthu
Magazine: FASEB Journal