Clearance of neurotoxic aggregates by autophagy
Selectieve verwijdering van neurotoxische eiwitaggregaten met autofagie
Vrijwel alle leeftijdsafhankelijke neurodegeneratieve ziektes, zoals Alzheimer’s, Parkinson’s en Huntington’s, ALS en diverse vormen van Ataxie, worden gekarakteriseerd door klontering van eiwitten. Deze zogenaamde eiwit aggregaten zorgen voor afsterving van zenuwcellen, waardoor deze ziektes ontstaan. Autofagie is een proces waarmee cellen deze eiwit aggregaten kunnen afbreken, maar vaak worden daarmee ook andere celonderdelen verwijderd. Dit kan ongewenste bijwerkingen hebben. In dit project combineren de groepen van Kampinga (UMCG), Reggiori (UMCG) en Kapitein (UU) hun complementaire kennis en technische expertise om te bestuderen hoe het proces van autofagie zo gemoduleerd kan worden dat vooral de neurotoxische aggregaten worden verwijderd. Het doel is om daarmee kennis te verwerven die toegepast kan worden in de ontwikkeling van nieuwe therapieën om de hierboven genoemde ziektes te voorkomen of te behandelen.
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Titel: Building the Cell
Auteur: Kapitein LC
Auteur: Kapitein LC
Titel: Chaperone mutations and human protein aggregation diseases
Auteur: Kampinga HH
Link: https://meetings.embo.org/event/19-protein-quality-control
Auteur: Kampinga HH
Link: https://meetings.embo.org/event/19-protein-quality-control
Titel: Protein aggregation and age-related degenerative diseases: role of molecular chaperones
Auteur: Kampinga HH
Link: https://congress.cellstressresponses.org/invited-speakers/
Auteur: Kampinga HH
Link: https://congress.cellstressresponses.org/invited-speakers/
Titel: The Nucleolus: a nuclear PQC center
Auteur: Kampinga HH
Auteur: Kampinga HH
Titel: Molecular chaperones, macroautophagy and protein aggregation diseases
Auteur: Kampinga HH
Link: https://ascb-embo2018.ascb.org/minisymp18/
Auteur: Kampinga HH
Link: https://ascb-embo2018.ascb.org/minisymp18/
Titel: Vac8 spatially confines autophagosome formation at the vacuole in S. cerevisiae
Auteur: Hollenstein DM, Go´mez-Sa´nchez R, Ciftci A, Kriegenburg F, Mari M, Torggler R, Licheva M, Reggiori F, Kraft C
Magazine: Journal of Cell Science
Begin- en eindpagina: 1-16
Link: https://jcs.biologists.org/content/132/22/jcs235002
Auteur: Hollenstein DM, Go´mez-Sa´nchez R, Ciftci A, Kriegenburg F, Mari M, Torggler R, Licheva M, Reggiori F, Kraft C
Magazine: Journal of Cell Science
Begin- en eindpagina: 1-16
Link: https://jcs.biologists.org/content/132/22/jcs235002
Titel: Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy
Auteur: Chen S, Mari M, Parashar S, Liu D, Cui Y, Reggiori F, Novick PJ, Ferro-Novick S
Magazine: PNAS
Begin- en eindpagina: 18530-18539
Link: https://www.pnas.org/content/117/31/18530
Auteur: Chen S, Mari M, Parashar S, Liu D, Cui Y, Reggiori F, Novick PJ, Ferro-Novick S
Magazine: PNAS
Begin- en eindpagina: 18530-18539
Link: https://www.pnas.org/content/117/31/18530
Titel: Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses
Auteur: Echavarria Consuegra L, Smit JM, Reggiori F
Magazine: Open Biology
Begin- en eindpagina: 1-20
Link: https://royalsocietypublishing.org/doi/10.1098/rsob.190009
Auteur: Echavarria Consuegra L, Smit JM, Reggiori F
Magazine: Open Biology
Begin- en eindpagina: 1-20
Link: https://royalsocietypublishing.org/doi/10.1098/rsob.190009
Titel: Probing aggrephagy using chemically-induced protein aggregates
Auteur: Janssen AFJ, Katrukha EA, Van Straaten W, Verlhac P, Reggiori F, Kapitein LC
Magazine: Nature Communications
Begin- en eindpagina: 4245-4245
Link: https://www.nature.com/articles/s41467-018-06674-4
Auteur: Janssen AFJ, Katrukha EA, Van Straaten W, Verlhac P, Reggiori F, Kapitein LC
Magazine: Nature Communications
Begin- en eindpagina: 4245-4245
Link: https://www.nature.com/articles/s41467-018-06674-4
Titel: Multilayered Control of Protein Turnover by TORC1 and Atg1
Auteur: Hu Z, Raucci S, Jaquenoud M, Hatakeyama R, Stumpe M, Rohr R, Reggiori F, De Virgilio C, Dengjel J
Magazine: Cell Reports
Begin- en eindpagina: 3486-3496
Link: https://www.sciencedirect.com/science/article/pii/S2211124719311246
Auteur: Hu Z, Raucci S, Jaquenoud M, Hatakeyama R, Stumpe M, Rohr R, Reggiori F, De Virgilio C, Dengjel J
Magazine: Cell Reports
Begin- en eindpagina: 3486-3496
Link: https://www.sciencedirect.com/science/article/pii/S2211124719311246
Titel: Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy
Auteur: Kraft C, Boya P, Codogno P, Elazar Z, Eskelinen E-L, Farrés J, Kirkin V, Jungbluth H, Martinez A, Pless O, Primard C, Proikas-Cezanne T, Simonsen A, Reggiori F
Magazine: Autophagy
Begin- en eindpagina: 347-351
Link: https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1515532
Auteur: Kraft C, Boya P, Codogno P, Elazar Z, Eskelinen E-L, Farrés J, Kirkin V, Jungbluth H, Martinez A, Pless O, Primard C, Proikas-Cezanne T, Simonsen A, Reggiori F
Magazine: Autophagy
Begin- en eindpagina: 347-351
Link: https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1515532
Titel: Probing aggrephagy using chemically-induced protein aggregates
Auteur: Janssen, Anne F. J., Katrukha, Eugene A., van Straaten, Wendy, Verlhac, Pauline, Reggiori, Fulvio, Kapitein, Lukas C.
Magazine: Nature Communications
Begin- en eindpagina: 4245-4245
Link: https://www.nature.com/articles/s41467-018-06674-4
Auteur: Janssen, Anne F. J., Katrukha, Eugene A., van Straaten, Wendy, Verlhac, Pauline, Reggiori, Fulvio, Kapitein, Lukas C.
Magazine: Nature Communications
Begin- en eindpagina: 4245-4245
Link: https://www.nature.com/articles/s41467-018-06674-4
Titel: Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling
Auteur: Landi A, Mari M, Wolf T, Kleiser S, Wolf T, Gretzmeyer C, Wilhelm I, Kiritsi D, Thünauer R, Geiger R, Nyström A, Reggiori F, Claudinon J, Römer W
Magazine: Life Science Alliance
Begin- en eindpagina: 1-15
Link: https://www.life-science-alliance.org/content/2/6/e201900422
Auteur: Landi A, Mari M, Wolf T, Kleiser S, Wolf T, Gretzmeyer C, Wilhelm I, Kiritsi D, Thünauer R, Geiger R, Nyström A, Reggiori F, Claudinon J, Römer W
Magazine: Life Science Alliance
Begin- en eindpagina: 1-15
Link: https://www.life-science-alliance.org/content/2/6/e201900422
Titel: Protein quality control pathways at the crossroad of synucleinopathies
Auteur: Mattos de EP, Wentink A, Nussbaum-Krammer C, Hansen C, Bergink S, Melki R, and Kampinga HH
Magazine: Journal of Parkinson's Disease
Begin- en eindpagina: 369-382
Link: https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd191790
Auteur: Mattos de EP, Wentink A, Nussbaum-Krammer C, Hansen C, Bergink S, Melki R, and Kampinga HH
Magazine: Journal of Parkinson's Disease
Begin- en eindpagina: 369-382
Link: https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd191790
Titel: Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses
Auteur: Echavarria-Consuegra, Liliana, Smit, Jolanda M., Reggiori, Fulvio
Magazine: Open Biology
Begin- en eindpagina: 19000-19000
Link: https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190009
Auteur: Echavarria-Consuegra, Liliana, Smit, Jolanda M., Reggiori, Fulvio
Magazine: Open Biology
Begin- en eindpagina: 19000-19000
Link: https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190009
Titel: The N terminus of the small heat shock protein HSPB7 drives its polyQ aggregation–suppressing activity
Auteur: Wu D, Vonk JJ, Salles F, Vonk D, Haslbeck M, Melki R, Bergink S, Kampinga HH
Magazine: Journal of Biological Chemistry
Begin- en eindpagina: 9985-9994
Link: https://www.jbc.org/content/294/25/9985
Auteur: Wu D, Vonk JJ, Salles F, Vonk D, Haslbeck M, Melki R, Bergink S, Kampinga HH
Magazine: Journal of Biological Chemistry
Begin- en eindpagina: 9985-9994
Link: https://www.jbc.org/content/294/25/9985
Titel: A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation
Auteur: Cui Y, Parashar S, Zahoor M, Needham PG, Mari M, Zhu M, Chen S, Ho H.-C, Reggiori F, Farhan H, Brodsky JL, Ferro-Novick S
Magazine: Science
Begin- en eindpagina: 53-60
Link: https://science.sciencemag.org/content/365/6448/53
Auteur: Cui Y, Parashar S, Zahoor M, Needham PG, Mari M, Zhu M, Chen S, Ho H.-C, Reggiori F, Farhan H, Brodsky JL, Ferro-Novick S
Magazine: Science
Begin- en eindpagina: 53-60
Link: https://science.sciencemag.org/content/365/6448/53
Titel: A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation
Auteur: Cui, Yixian, Parashar, Smriti, Zahoor, Muhammad, Needham, Patrick G., Mari, Muriel, Zhu, Ming, Chen, Shuliang, Ho, Hsuan-Chung, Reggiori, Fulvio, Farhan, Hesso, Brodsky, Jeffrey L., Ferro-Novick, Susan
Magazine: Science
Begin- en eindpagina: 53-60
Auteur: Cui, Yixian, Parashar, Smriti, Zahoor, Muhammad, Needham, Patrick G., Mari, Muriel, Zhu, Ming, Chen, Shuliang, Ho, Hsuan-Chung, Reggiori, Fulvio, Farhan, Hesso, Brodsky, Jeffrey L., Ferro-Novick, Susan
Magazine: Science
Begin- en eindpagina: 53-60