Developing a non-invasive biomarker for early BBB breakdown in Alzheimer’s disease (DEBBIE)
Een van de eerste tekenen van Alzheimer en andere vormen van dementie, is het zwakker worden van de bloed-hersenbarrière (BHB). De BHB is een filter tussen het bloed en de hersenen, die selectief noodzakelijke voedingstoffen doorlaat en schadelijke stoffen en organismen blokkeert. De MRI scantechniek ASL kan de hersendoorbloeding afbeelden zonder het gebruik van contrastmiddel of radioactieve straling.
Doel
Het internationale project DEBBIE ontwikkelt ASL MRI verder zodat deze geschikt wordt om de intactheid van de BHB in kaart te brengen.
Aanpak
Wij zullen de BHB beeldanalyse standaardiseren voor MRI scanners van verschillende fabrikanten en een referentiekaart van normale BHB intactheid ontwikkelen.
Verwachte resultaten
Deze ontwikkelingen zullen artsen in staat stellen om de effecten van dementie op de bloed-hersenbarrière in een vroeg stadium te detecteren. Dit kan cruciaal zijn voor het begrip van deze ziekten. Het kan helpen bij het selecteren van patiënten voor toekomstige behandeling.
Meer informatie
Factsheet DEBBIE
Producten
Titel: ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): ASL pipeline inventory
Auteur: Fan H, Mutsaerts HJMM, Anazodo U, Arteaga D, Baas KPA, Buchanan C, Camargo A, Keil VC, Lin Z, Lindner T, Hirschler L, Hu J, Esteves Padrela B, Taghvaei M, Thomas DL, Dolui S, Petr J
Magazine: Magnetic Resonance in Medicine
Link: https://pubmed.ncbi.nlm.nih.gov/37811778/
Auteur: Fan H, Mutsaerts HJMM, Anazodo U, Arteaga D, Baas KPA, Buchanan C, Camargo A, Keil VC, Lin Z, Lindner T, Hirschler L, Hu J, Esteves Padrela B, Taghvaei M, Thomas DL, Dolui S, Petr J
Magazine: Magnetic Resonance in Medicine
Link: https://pubmed.ncbi.nlm.nih.gov/37811778/
Titel: Reproducibility of 3 T APT-CEST in Healthy Volunteers and Patients With Brain Glioma
Auteur: Wamelink IJHG, Padrela B, Kuijer JPA, Zhang Y, Barkhof F, Mutsaerts HJMM, Van de Giessen E, Keil VC
Magazine: Journal of Magnetic Resonance Imaging
Link: https://pubmed.ncbi.nlm.nih.gov/35633282/
Auteur: Wamelink IJHG, Padrela B, Kuijer JPA, Zhang Y, Barkhof F, Mutsaerts HJMM, Van de Giessen E, Keil VC
Magazine: Journal of Magnetic Resonance Imaging
Link: https://pubmed.ncbi.nlm.nih.gov/35633282/
Titel: Reproducibility of 3 T APT-CEST in Healthy Volunteers and Patients With Brain Glioma
Auteur: Ivar J H G Wamelink , Joost P A Kuijer , Beatriz E Padrela , Yi Zhang , Frederik Barkhof , Henk J M M Mutsaerts , Jan Petr , Elsmarieke van de Giessen , Vera C Keil
Magazine: Journal of Magnetic Resonance Imagine
Link: https://pubmed.ncbi.nlm.nih.gov/35633282/
Auteur: Ivar J H G Wamelink , Joost P A Kuijer , Beatriz E Padrela , Yi Zhang , Frederik Barkhof , Henk J M M Mutsaerts , Jan Petr , Elsmarieke van de Giessen , Vera C Keil
Magazine: Journal of Magnetic Resonance Imagine
Link: https://pubmed.ncbi.nlm.nih.gov/35633282/
Titel: ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): ASL pipeline inventory
Auteur: Hongli Fan, Henk J M M Mutsaerts, Udunna Anazodo , Daniel Arteaga , Koen P A Baas, Charlotte Buchanan , Aldo Camargo , Vera C Keil , Zixuan Lin , Thomas Lindner , Lydiane Hirschler , Jian Hu , Beatriz E Padrela , Mohammad Taghvaei , David L Thomas , Sudipto Dolui, Jan Petr
Magazine: Magnetic Resonance Medicine
Link: https://pubmed.ncbi.nlm.nih.gov/37811778/
Auteur: Hongli Fan, Henk J M M Mutsaerts, Udunna Anazodo , Daniel Arteaga , Koen P A Baas, Charlotte Buchanan , Aldo Camargo , Vera C Keil , Zixuan Lin , Thomas Lindner , Lydiane Hirschler , Jian Hu , Beatriz E Padrela , Mohammad Taghvaei , David L Thomas , Sudipto Dolui, Jan Petr
Magazine: Magnetic Resonance Medicine
Link: https://pubmed.ncbi.nlm.nih.gov/37811778/
Titel: DEveloping BBB-ASL as non-Invasive Early biomarker of Alzheimer’s Disease (DEBBIE-AD): A prospective observational multi-cohort study protocol
Auteur: Padrela BE, Mahroo A, Tee M, Sneve MH, Moyaert P, Geier O, Kuijer JPA, Beun S, Nordhøy W, Zhu YD, Buck MA, Hoinkiss DC, Konstandin S, Huber J, Wiersinga J, Rikken R, De Leeuw D, Grydeland H, Tippett L, Cawston EE, Ozturk-Isik E, Linn J, Brandt M, Tijms B, Van de Giessen E, Muller M, Fjell AM, Walhovd KB, Pålhaugen L, Selnes P, Clement P, Achten E, Anazodo U, Barkhof F, Hilal S, Fladby T, Eickel K, Morgan C, Thomas DL, Petr J, Günther M, Mutsaerts HJMM
Magazine: BMJ Open
Link: https://pubmed.ncbi.nlm.nih.gov/38458785/
Auteur: Padrela BE, Mahroo A, Tee M, Sneve MH, Moyaert P, Geier O, Kuijer JPA, Beun S, Nordhøy W, Zhu YD, Buck MA, Hoinkiss DC, Konstandin S, Huber J, Wiersinga J, Rikken R, De Leeuw D, Grydeland H, Tippett L, Cawston EE, Ozturk-Isik E, Linn J, Brandt M, Tijms B, Van de Giessen E, Muller M, Fjell AM, Walhovd KB, Pålhaugen L, Selnes P, Clement P, Achten E, Anazodo U, Barkhof F, Hilal S, Fladby T, Eickel K, Morgan C, Thomas DL, Petr J, Günther M, Mutsaerts HJMM
Magazine: BMJ Open
Link: https://pubmed.ncbi.nlm.nih.gov/38458785/
Titel: Associations between potential risk factors and blood-brain barrier water permeability in middle-aged and older adults
Auteur: Tee M, Padrela BE, Dupeyron M, Huang J, Low M, Konstandin S, Eickel K, Günther M, Minta K, Schinazi VR, Colombo G, Petr J, Mutsaerts HJMM, Hilal S
Magazine: Journal of Alzheimer’s Disease
Link: https://pubmed.ncbi.nlm.nih.gov/39814543/
Auteur: Tee M, Padrela BE, Dupeyron M, Huang J, Low M, Konstandin S, Eickel K, Günther M, Minta K, Schinazi VR, Colombo G, Petr J, Mutsaerts HJMM, Hilal S
Magazine: Journal of Alzheimer’s Disease
Link: https://pubmed.ncbi.nlm.nih.gov/39814543/
Titel: Blood-brain barrier water permeability across the adult lifespan: A multi-echo ASL study
Auteur: Padrela BE, Slivka M, Sneve MH, Garrido PF, Dijsselhof MBJ, Hageman T, Geier O, Grydeland H, Mahroo A, Kuijer JPA, Konstandin S, Eickel K, Barkhof F, Gu¨nther M, Walhovd KB, Fjell AM, Mutsaerts HJMM, Petr J
Magazine: Neurobiology of Aging
Link: https://pubmed.ncbi.nlm.nih.gov/39798256/
Auteur: Padrela BE, Slivka M, Sneve MH, Garrido PF, Dijsselhof MBJ, Hageman T, Geier O, Grydeland H, Mahroo A, Kuijer JPA, Konstandin S, Eickel K, Barkhof F, Gu¨nther M, Walhovd KB, Fjell AM, Mutsaerts HJMM, Petr J
Magazine: Neurobiology of Aging
Link: https://pubmed.ncbi.nlm.nih.gov/39798256/
Titel: Robust Multi-TE ASL-Based Blood-Brain Barrier Integrity Measurements
Auteur: Amnah Mahroo , Mareike Alicja Buck , Jörn Huber , Nora-Josefin Breutigam , Henk J M M Mutsaerts , Martin Craig , Michael Chappell , Matthias Günther
Magazine: Frontiers Neuroscience
Link: https://pubmed.ncbi.nlm.nih.gov/34924924/
Auteur: Amnah Mahroo , Mareike Alicja Buck , Jörn Huber , Nora-Josefin Breutigam , Henk J M M Mutsaerts , Martin Craig , Michael Chappell , Matthias Günther
Magazine: Frontiers Neuroscience
Link: https://pubmed.ncbi.nlm.nih.gov/34924924/
Titel: The Reproducibility of arterial spin labeling cerebral blood flow image processing: A report of the ISMRM open science initiative for perfusion imaging (OSIPI) and the ASL MRI challenge
Auteur: Paschoal A, Woods JG, Pinto J, Kennedy McConnell FA, Bell L, Dounavi ME, Gould van Praag C, Mutsaerts H, Oliver-Taylor A, Petr J, Zhao MY, Brumer I, Siang Marcus Chain W, Toner J, Hu J, Zhang LX, Domingos C, Monteiro SP, Figueiredo P, Harms AGJ, Bron E, Padrela BE, Croal PL, Anazodo U
Magazine: Magnetic Resonance in Medicine
Link: https://pubmed.ncbi.nlm.nih.gov/38502108/
Auteur: Paschoal A, Woods JG, Pinto J, Kennedy McConnell FA, Bell L, Dounavi ME, Gould van Praag C, Mutsaerts H, Oliver-Taylor A, Petr J, Zhao MY, Brumer I, Siang Marcus Chain W, Toner J, Hu J, Zhang LX, Domingos C, Monteiro SP, Figueiredo P, Harms AGJ, Bron E, Padrela BE, Croal PL, Anazodo U
Magazine: Magnetic Resonance in Medicine
Link: https://pubmed.ncbi.nlm.nih.gov/38502108/
Titel: A Beginner’s Guide to Arterial Spin Labeling (ASL) Image Processing
Auteur: Clement P, Petr J, Dijsselhof MBJ, Padrela B, Pasternak M, Dolui S, Jarutyte L, Pinter N, Hernandez Garcia L, Jahn A, Kuijer JPA, Barkhof F, Mutsaerts HJMM* & Keil VC*
Magazine: Frontiers in Radiology
Link: https://pubmed.ncbi.nlm.nih.gov/37492666/
Auteur: Clement P, Petr J, Dijsselhof MBJ, Padrela B, Pasternak M, Dolui S, Jarutyte L, Pinter N, Hernandez Garcia L, Jahn A, Kuijer JPA, Barkhof F, Mutsaerts HJMM* & Keil VC*
Magazine: Frontiers in Radiology
Link: https://pubmed.ncbi.nlm.nih.gov/37492666/
Titel: Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population
Auteur: Padrela BE, Lorenzini L, Collij LE, Vállez Garcia D, Coomans E, Ingala S, Tomassen J, Deckers Q, Shekari M, De Geus EJC, Van de Giessen E, Ten Kate M, Visser PJ, Barkhof F, Petr J, Den Braber A, Mutsaerts HJMM
Magazine: Journal of Cerebral Blood Flow & Metabolism
Link: https://pubmed.ncbi.nlm.nih.gov/37231665/
Auteur: Padrela BE, Lorenzini L, Collij LE, Vállez Garcia D, Coomans E, Ingala S, Tomassen J, Deckers Q, Shekari M, De Geus EJC, Van de Giessen E, Ten Kate M, Visser PJ, Barkhof F, Petr J, Den Braber A, Mutsaerts HJMM
Magazine: Journal of Cerebral Blood Flow & Metabolism
Link: https://pubmed.ncbi.nlm.nih.gov/37231665/
Titel: Robust Multi-TE ASL-Based Blood-Brain Barrier Integrity Measurements
Auteur: Amnah Mahroo 1 , Mareike Alicja Buck 1 2 , Jörn Huber 1 , Nora-Josefin Breutigam 1 , Henk J M M Mutsaerts 3 , Martin Craig 4 5 6 , Michael Chappell 4 5 6 7 , Matthias Günther 1 2 8
Magazine: Frontiers Neuroscience
Link: https://pubmed.ncbi.nlm.nih.gov/34924924/
Auteur: Amnah Mahroo 1 , Mareike Alicja Buck 1 2 , Jörn Huber 1 , Nora-Josefin Breutigam 1 , Henk J M M Mutsaerts 3 , Martin Craig 4 5 6 , Michael Chappell 4 5 6 7 , Matthias Günther 1 2 8
Magazine: Frontiers Neuroscience
Link: https://pubmed.ncbi.nlm.nih.gov/34924924/
Titel: Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective
Auteur: Paulien Moyaert , Beatriz E Padrela , Catherine A Morgan , Jan Petr , Jan Versijpt , Frederik Barkhof, Michael T Jurkiewicz , Xingfeng Shao , Olujide Oyeniran , Tabitha Manson , Danny J J Wang , Matthias Günther, Eric Achten , Henk J M M Mutsaerts , Udunna C Anazodo
Magazine: Frontiers Aging Neuroscience
Link: https://pubmed.ncbi.nlm.nih.gov/37139088/
Auteur: Paulien Moyaert , Beatriz E Padrela , Catherine A Morgan , Jan Petr , Jan Versijpt , Frederik Barkhof, Michael T Jurkiewicz , Xingfeng Shao , Olujide Oyeniran , Tabitha Manson , Danny J J Wang , Matthias Günther, Eric Achten , Henk J M M Mutsaerts , Udunna C Anazodo
Magazine: Frontiers Aging Neuroscience
Link: https://pubmed.ncbi.nlm.nih.gov/37139088/
Titel: A Beginner's Guide to Arterial Spin Labeling (ASL) Image Processing
Auteur: Patricia Clement , Jan Petr , Mathijs B J Dijsselhof , Beatriz Padrela , Maurice Pasternak , Sudipto Dolui , Lina Jarutyte , Nandor Pinter , Luis Hernandez-Garcia , Andrew Jahn , Joost P A Kuijer , Frederik Barkhof , Henk J M M Mutsaerts , Vera C Keil
Magazine: Frontiers Radiology
Link: https://pubmed.ncbi.nlm.nih.gov/37492666/
Auteur: Patricia Clement , Jan Petr , Mathijs B J Dijsselhof , Beatriz Padrela , Maurice Pasternak , Sudipto Dolui , Lina Jarutyte , Nandor Pinter , Luis Hernandez-Garcia , Andrew Jahn , Joost P A Kuijer , Frederik Barkhof , Henk J M M Mutsaerts , Vera C Keil
Magazine: Frontiers Radiology
Link: https://pubmed.ncbi.nlm.nih.gov/37492666/
Titel: Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective
Auteur: Moyaert P, Padrela B, Morgan C, Petr J, Versijpt J, Barkhof F, Jurkiewicz MT, Shao X, Oyeniran O, Manson T, Wang DJJ, Günther M, Achten E, Mutsaerts HJMM, Anazodo UC
Magazine: Frontiers in Aging Neuroscience
Link: https://pubmed.ncbi.nlm.nih.gov/37139088/
Auteur: Moyaert P, Padrela B, Morgan C, Petr J, Versijpt J, Barkhof F, Jurkiewicz MT, Shao X, Oyeniran O, Manson T, Wang DJJ, Günther M, Achten E, Mutsaerts HJMM, Anazodo UC
Magazine: Frontiers in Aging Neuroscience
Link: https://pubmed.ncbi.nlm.nih.gov/37139088/
Titel: Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population
Auteur: Beatriz E Padrela , Luigi Lorenzini , Lyduine E Collij , David Vállez García, Emma Coomans , Silvia Ingala , Jori Tomassen , Quinten Deckers , Mahnaz Shekari , Eco Jc de Geus , Elsmarieke van de Giessen , Mara Ten Kate , Pieter Jelle Visser , Frederik Barkhof , Jan Petr , Anouk den Braber , Henk Jmm Mutsaerts
Magazine: Journal of Cerebral Blood Flow and Metabolism (JCBFM)
Link: https://pubmed.ncbi.nlm.nih.gov/37231665/
Auteur: Beatriz E Padrela , Luigi Lorenzini , Lyduine E Collij , David Vállez García, Emma Coomans , Silvia Ingala , Jori Tomassen , Quinten Deckers , Mahnaz Shekari , Eco Jc de Geus , Elsmarieke van de Giessen , Mara Ten Kate , Pieter Jelle Visser , Frederik Barkhof , Jan Petr , Anouk den Braber , Henk Jmm Mutsaerts
Magazine: Journal of Cerebral Blood Flow and Metabolism (JCBFM)
Link: https://pubmed.ncbi.nlm.nih.gov/37231665/
Titel: Quantitative Perfusion MRI - Techniques, Applications and Practical Considerations (Chapter 4 - Arterial spin labeling MRI)
Auteur: Mathijs Dijsselhof, Beatriz E Padrela, Jan Petr, Henk-Jan MM Mutsaerts
Link: https://www.sciencedirect.com/bookseries/advances-in-magnetic-resonance-technology-and-applications/vol/11/suppl/C
Auteur: Mathijs Dijsselhof, Beatriz E Padrela, Jan Petr, Henk-Jan MM Mutsaerts
Link: https://www.sciencedirect.com/bookseries/advances-in-magnetic-resonance-technology-and-applications/vol/11/suppl/C
Titel: Amyloid Burden & Vascular Risk Factors Correlate with Regional Cerebral Blood Flow in a Cognitively Unimpaired Population
Auteur: Padrela BE, Lorenzini L, Collij LE, Ten Kate M, Den Braber A, Tomassen J, Van Berckel B, Visser PJ, Barkhof F, Petr J, Mutsaerts HJMM
Link: https://archive.ismrm.org/2022/0077.html
Auteur: Padrela BE, Lorenzini L, Collij LE, Ten Kate M, Den Braber A, Tomassen J, Van Berckel B, Visser PJ, Barkhof F, Petr J, Mutsaerts HJMM
Link: https://archive.ismrm.org/2022/0077.html
Titel: ASL spatial coefficient of variance predicts increased white matter hyperintensities volume over time in cognitively unimpaired subjects
Auteur: Padrela BE, Collij LE, Lorenzini L, Ingala S, Sudre C, Visser PJ, Den Braber A, Barkhof F, Petr J, Mutsaerts HJMM
Link: https://adpd2023.kenes.com/scientific-program/
Auteur: Padrela BE, Collij LE, Lorenzini L, Ingala S, Sudre C, Visser PJ, Den Braber A, Barkhof F, Petr J, Mutsaerts HJMM
Link: https://adpd2023.kenes.com/scientific-program/
Titel: DEveloping Blood-Brain barrier arterial spin labeling as a non-Invasive Early biomarker (DEBBIE) 2023 ISMRM, Toronto, Canada (oral)
Auteur: Padrela BE, Tee M, Sneve M, Mahroo A, Geier O, Thomas DL, Morgan C, Moyaert P, Ozturk E, Nordhøy W, Pålhaugen L, Linn J, Selnes P, Eickel K, Konstandin S, Kuijer JPA, Hoinkiss D, Breutigam N, Buck M, Achten R, Barkhof F, Hilal S, Fladby T, Anazodo U, Petr J, Mutsaerts HJMM, Günther M
Link: https://www.ismrm.org/23/program-files/O-26.htm
Auteur: Padrela BE, Tee M, Sneve M, Mahroo A, Geier O, Thomas DL, Morgan C, Moyaert P, Ozturk E, Nordhøy W, Pålhaugen L, Linn J, Selnes P, Eickel K, Konstandin S, Kuijer JPA, Hoinkiss D, Breutigam N, Buck M, Achten R, Barkhof F, Hilal S, Fladby T, Anazodo U, Petr J, Mutsaerts HJMM, Günther M
Link: https://www.ismrm.org/23/program-files/O-26.htm