Dissecting the pathogenesis of measles: studies on virus transmission and immunosuppression
Hoe wordt het mazelen virus overgedragen en veroorzaakt het ziekte?
Mazelen is in ontwikkelingslanden nog steeds de oorzaak van enkele honderdduizenden doden per jaar. De veroorzaker, het mazelen virus, is zeer besmettelijk en wordt overgedragen door aanhoesten van kleine waterdruppels. Na ongeveer twee weken krijgt de gastheer hoge koorts en de bekende rode huiduitslag. Het virus verzwakt het afweersysteem, waardoor mazelen patiënten gemakkelijk longontsteking of ernstige diarree kunnen krijgen. Hoewel al vroeg in de 20ste eeuw is aangetoond dat mazelen veroorzaakt wordt door een virus, is nog steeds onduidelijk welke cellen het eerst worden geïnfecteerd en hoe het virus daarna wordt verspreid in het lichaam. Onze studies zijn er op gericht de processen van overdracht en immuunsuppressie beter te begrijpen.
Producten
Titel: Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases
Auteur: Mesman AW, Zijlstra-Willems EM, Kaptein ™, De Swart RL, Davis ME, Ludlow M, Duprex WP, Gack MU, Gringhuis SI and Geijtenbeek TBH.
Magazine: Cell Host and Microbe
Auteur: Mesman AW, Zijlstra-Willems EM, Kaptein ™, De Swart RL, Davis ME, Ludlow M, Duprex WP, Gack MU, Gringhuis SI and Geijtenbeek TBH.
Magazine: Cell Host and Microbe
Titel: Early Target Cells of Measles Virus after Aerosol Infection of Non-Human Primates
Auteur: Ken Lemon , Rory de Vries , Annelies Mesman , Stephen McQuaid , Geert van Amerongen , Selma Yüksel , Martin Ludlow , Linda Rennick , Thijs Kuiken , Bertus Rima , Teunis Geijtenbeek , Albert Osterhaus , Rik de Swart
Auteur: Ken Lemon , Rory de Vries , Annelies Mesman , Stephen McQuaid , Geert van Amerongen , Selma Yüksel , Martin Ludlow , Linda Rennick , Thijs Kuiken , Bertus Rima , Teunis Geijtenbeek , Albert Osterhaus , Rik de Swart
Titel: Human immature Langerhans cells restrict CXCR4-using HIV-1 transmission
Auteur: Sarrami-Forooshani R, Mesman AW, Van teijlingen NH, Sprokholt JK, Van der Vlist M, Ribeiro CMS and Geijtenbeek TBH.
Magazine: Retrovirology
Auteur: Sarrami-Forooshani R, Mesman AW, Van teijlingen NH, Sprokholt JK, Van der Vlist M, Ribeiro CMS and Geijtenbeek TBH.
Magazine: Retrovirology
Titel: Using the ferret model to study morbillivirus entry, spread, transmission and cross-protection
Auteur: Ludlow M, LJ Rennick, S Nambulli, RL de Swart and WP Duprex
Magazine: Current Opinion in Virology
Auteur: Ludlow M, LJ Rennick, S Nambulli, RL de Swart and WP Duprex
Magazine: Current Opinion in Virology
Titel: Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus
Auteur: Martin Ludlow, Rory D. de Vries, Ken Lemon, Stephen McQuaid, Emma Millar, Geert van Amerongen, Selma Yüksel, R. Joyce Verburgh, Albert D. M. E. Osterhaus, Rik L. de Swart and W. Paul Duprex
Magazine: Journal of General Virology
Auteur: Martin Ludlow, Rory D. de Vries, Ken Lemon, Stephen McQuaid, Emma Millar, Geert van Amerongen, Selma Yüksel, R. Joyce Verburgh, Albert D. M. E. Osterhaus, Rik L. de Swart and W. Paul Duprex
Magazine: Journal of General Virology
Titel: Measles virus infection of epithelial cells in the macaque upper respiratory tract is mediated by sub-epithelial immune cells
Auteur: Martin Ludlow, Ken Lemon, Rory D. de Vries, Stephen McQuaid, Emma L. Millar, Geert van Amerongen, Selma Yüksel, R. Joyce Verburgh, Albert D. M. E. Osterhaus, Rik L. de Swart and W. Paul Duprex
Magazine: Journal of Virology
Auteur: Martin Ludlow, Ken Lemon, Rory D. de Vries, Stephen McQuaid, Emma L. Millar, Geert van Amerongen, Selma Yüksel, R. Joyce Verburgh, Albert D. M. E. Osterhaus, Rik L. de Swart and W. Paul Duprex
Magazine: Journal of Virology
Titel: In Vivo Tropism of Attenuated and Pathogenic Measles Virus Expressing Green Fluorescent Protein in Macaques
Auteur: Rory D. de Vries, Ken Lemon, Martin Ludlow, Stephen McQuaid, Selma Yüksel, Geert van Amerongen, Linda J. Rennick, Bert K. Rima, Albert D. M. E. Osterhaus, Rik L. de Swart, W. Paul Duprex
Magazine: Journal of Virology
Auteur: Rory D. de Vries, Ken Lemon, Martin Ludlow, Stephen McQuaid, Selma Yüksel, Geert van Amerongen, Linda J. Rennick, Bert K. Rima, Albert D. M. E. Osterhaus, Rik L. de Swart, W. Paul Duprex
Magazine: Journal of Virology
Titel: Rinderpest eradication: lessons for measles eradication?
Auteur: R.L. de Swart, W.P. Duprex, A.D.M.E. Osterhaus
Magazine: Current Opinion in Virology
Auteur: R.L. de Swart, W.P. Duprex, A.D.M.E. Osterhaus
Magazine: Current Opinion in Virology
Titel: Paramyxovirus infections in ex vivo lung slice cultures of different host species
Auteur: D. Tien Nguyen, Rory D. de Vries, Martin Ludlow, Bernadette G. van den Hoogen, Ken Lemon, Geert van Amerongen, Albert D.M.E. Osterhaus, Rik L. de Swart and W. Paul Duprex
Magazine: Journal of Virological Methods
Auteur: D. Tien Nguyen, Rory D. de Vries, Martin Ludlow, Bernadette G. van den Hoogen, Ken Lemon, Geert van Amerongen, Albert D.M.E. Osterhaus, Rik L. de Swart and W. Paul Duprex
Magazine: Journal of Virological Methods
Titel: Evaluating measles vaccines: can we assess cellular immunity?
Auteur: Rory D. de Vries and Rik L. de Swart
Magazine: Expert Reviews of Vaccines
Auteur: Rory D. de Vries and Rik L. de Swart
Magazine: Expert Reviews of Vaccines
Titel: Evaluation of synthetic infection-enhancing lipopeptides as adjuvants for a live-attenuated canine distemper virus vaccine administered intra-nasally to ferrets
Auteur: D. Tien Nguyen, Martin Ludlow, Geert van Amerongen, Rory D. de Vries, Selma Yuksel, R. Joyce Verburgh, Albert D.M.E. Osterhaus, W. Paul Duprex and Rik L. de Swart
Magazine: Vaccine
Auteur: D. Tien Nguyen, Martin Ludlow, Geert van Amerongen, Rory D. de Vries, Selma Yuksel, R. Joyce Verburgh, Albert D.M.E. Osterhaus, W. Paul Duprex and Rik L. de Swart
Magazine: Vaccine
Titel: A prominent role for DC-SIGN(+) dendritic cells in initiation and dissemination of measles virus infection in non-human primates
Auteur: Annelies W. Mesman, Rory D. de Vries, Stephen McQuaid, W. Paul Duprex, Rik L. de Swart and Teunis B.H. Geijtenbeek.
Magazine: PLoS Pathogens
Auteur: Annelies W. Mesman, Rory D. de Vries, Stephen McQuaid, W. Paul Duprex, Rik L. de Swart and Teunis B.H. Geijtenbeek.
Magazine: PLoS Pathogens
Titel: Recombinant canine distemper virus strain Snyder Hill expressing green or red fluorescent proteins causes meningoencephalitis in the ferret
Auteur: M. Ludlow, D.T. Nguyen, D. Silin, O. Lyubomska, R.D. de Vries, V. von Messling, S. McQuaid, R.L. de Swart and W.P. Duprex
Magazine: Journal of Virology
Auteur: M. Ludlow, D.T. Nguyen, D. Silin, O. Lyubomska, R.D. de Vries, V. von Messling, S. McQuaid, R.L. de Swart and W.P. Duprex
Magazine: Journal of Virology
Titel: Infection-enhancing lipopeptides do not improve intranasal immunization of cotton rats with a delta-G candidate live-attenuated human respiratory syncytial virus vaccine
Auteur: D. Tien Nguyen, Jolande Boes, Geert van Amerongen, Yvonne van Remmerden, Selma Yüksel, Teun Guichelaar, Albert D. M. E. Osterhaus and Rik L. de Swart
Magazine: Human Vaccines and Immunotherapeutics
Auteur: D. Tien Nguyen, Jolande Boes, Geert van Amerongen, Yvonne van Remmerden, Selma Yüksel, Teun Guichelaar, Albert D. M. E. Osterhaus and Rik L. de Swart
Magazine: Human Vaccines and Immunotherapeutics
Titel: Pattern recognition receptors in HIV transmission
Auteur: Annelies W. Mesman and Teunis B. Geijtenbeek
Magazine: Frontiers in Immunology
Auteur: Annelies W. Mesman and Teunis B. Geijtenbeek
Magazine: Frontiers in Immunology
Titel: Measles immune suppression: lessons from the macaque model
Auteur: Rory D. de Vries, Stephen McQuaid, Geert van Amerongen, Selma Yuksel, R. Joyce Verburgh, Albert D.M.E. Osterhaus, W. Paul Duprex and Rik L. de Swart
Magazine: PLoS Pathogens
Auteur: Rory D. de Vries, Stephen McQuaid, Geert van Amerongen, Selma Yuksel, R. Joyce Verburgh, Albert D.M.E. Osterhaus, W. Paul Duprex and Rik L. de Swart
Magazine: PLoS Pathogens
Titel: Specific CD8+ T-lymphocytes control dissemination of measles virus
Auteur: Rory D. de Vries, Selma Yüksel, Albert D.M.E. Osterhaus, Rik L. de Swart
Magazine: European Journal of Immunology
Auteur: Rory D. de Vries, Selma Yüksel, Albert D.M.E. Osterhaus, Rik L. de Swart
Magazine: European Journal of Immunology
Titel: Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross-presentation
Auteur: Michiel van der Vlist, Lot de Witte*, Rory D. de Vries*, Manja Litjens, Marein A.W.P. de Jong, Donna Fluitsma, Rik L. de Swart and Theunis B.H. Geijtenbeek * these authors contributed equally to this work
Magazine: European Journal of Immunology
Auteur: Michiel van der Vlist, Lot de Witte*, Rory D. de Vries*, Manja Litjens, Marein A.W.P. de Jong, Donna Fluitsma, Rik L. de Swart and Theunis B.H. Geijtenbeek * these authors contributed equally to this work
Magazine: European Journal of Immunology
Titel: The pathogenesis of measles
Auteur: R.D. de Vries, A.W. Mesman, T.B.H. Geijtenbeek, W.P. Duprex, R.L. de Swart
Magazine: Current Opinion in Virology
Auteur: R.D. de Vries, A.W. Mesman, T.B.H. Geijtenbeek, W.P. Duprex, R.L. de Swart
Magazine: Current Opinion in Virology
Titel: Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5
Auteur: Davis ME, Wang MK, Rennick LJ, Full F, Gableske S, Mesman AW, Gringhuis SI, Geijtenbeek TBH, Duprex WP and Gack MU.
Magazine: Cell Host and Microbe
Auteur: Davis ME, Wang MK, Rennick LJ, Full F, Gableske S, Mesman AW, Gringhuis SI, Geijtenbeek TBH, Duprex WP and Gack MU.
Magazine: Cell Host and Microbe
Titel: Early Target Cells of Measles Virus after Aerosol Infection of Non-Human Primates
Auteur: Ken Lemon*, Rory D. de Vries*, Annelies W. Mesman, Stephen McQuaid, Geert van Amerongen, Selma Yüksel, Martin Ludlow, Linda J. Rennick, Thijs Kuiken, Bertus K. Rima, Teunis B. H. Geijtenbeek, Albert D. M. E. Osterhaus, W. Paul Duprex and Rik L. de Swart *these authors contributed equally to this work
Magazine: PLoS Pathogens
Auteur: Ken Lemon*, Rory D. de Vries*, Annelies W. Mesman, Stephen McQuaid, Geert van Amerongen, Selma Yüksel, Martin Ludlow, Linda J. Rennick, Thijs Kuiken, Bertus K. Rima, Teunis B. H. Geijtenbeek, Albert D. M. E. Osterhaus, W. Paul Duprex and Rik L. de Swart *these authors contributed equally to this work
Magazine: PLoS Pathogens
Titel: Measles vaccination of non-human primates provides partial protection against infection with canine distemper virus
Auteur: De Vries RD, M. Ludlow, RJ Verburgh, G van Amerongen, S Yüksel, DT Nguyen, S McQuaid, RS van Binnendijk, ADME Osterhaus, WP Duprex and RL de Swart
Magazine: Journal of Virology
Auteur: De Vries RD, M. Ludlow, RJ Verburgh, G van Amerongen, S Yüksel, DT Nguyen, S McQuaid, RS van Binnendijk, ADME Osterhaus, WP Duprex and RL de Swart
Magazine: Journal of Virology
Titel: Measles immune suppression: functional impairment or numbers game?
Auteur: R.D. de Vries and R.L. de Swart
Magazine: PLoS Pathogens
Auteur: R.D. de Vries and R.L. de Swart
Magazine: PLoS Pathogens
Titel: Human Respiratory Viral Infections
Auteur: RD de Vries and RL de Swart
Auteur: RD de Vries and RL de Swart
Titel: Reverse genetics of RNA viruses: applications and perspectives
Auteur: Linda J. Rennick and W. Paul Duprex
Link: http://dx.doi.org/10.1002/9781118405338.ch6
Auteur: Linda J. Rennick and W. Paul Duprex
Link: http://dx.doi.org/10.1002/9781118405338.ch6
Titel: Novel insights into measles pathogenesis and immune suppression
Auteur: Rory D. de Vries
Auteur: Rory D. de Vries