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Functional Brain Networks: Individual Integrity in Aging and Dementia

Het vinden van een vroege biomarker is de heilige graal in het diagnostisch onderzoek naar dementie. Hiervoor kunnen MRI-scans van functionele hersennetwerken veelbelovend zijn. De bestaande technieken hebben tot dusver geen individuele biomarkers opgeleverd.
In dit onderzoek hebben we geavanceerde machine learning technologieën ontwikkeld en toegepast om informatie van verschillende soorten MRI-scans te combineren: scans van functionele verbindingen in de hersenen, structurele verbindingen en regionale hersenvolumes.
We hebben aangetoond dat de resulterende multidimensionale MRI-dementiescores kunnen worden gebruikt voor automatische classificatie van individuele dementiepatiënten uitsluitend op basis van MRI-informatie van de hersenen. Deze hebben potentieel als een nuttig hulpmiddel voor diagnose. Maar hoe eerder in het ziekteproces, hoe moeilijker het is om vroege MRI kenmerken van dementie in de hersenen te ontdekken.

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Titel: Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI
Auteur: Rogier A. Feis, Mark J.R.J. Bouts, Jessica L. Panman, Lize C. Jiskoot, Elise G.P. Dopper, Tijn M. Schouten, Frank de Vos, Jeroen van der Grond, John C. van Swieten, Serge A.R.B. Rombouts
Magazine: Neuroimage Clinical
Titel: Different patterns of cortical gray matter loss over time in behavioral variant frontotemporal dementia and Alzheimer's disease
Auteur: Möller, Christiane, Hafkemeijer, Anne, Pijnenburg, Yolande A.L., Rombouts, Serge A.R.B., van der Grond, Jeroen, Dopper, Elise, van Swieten, John, Versteeg, Adriaan, Steenwijk, Martijn D., Barkhof, Frederik, Scheltens, Philip, Vrenken, Hugo, van der Flier, Wiesje M.
Magazine: Neurobiology of Aging
Titel: Individual classification of Alzheimer's disease with diffusion magnetic resonance imaging
Auteur: Schouten, Tijn M., Koini, Marisa, Vos, Frank de, Seiler, Stephan, Rooij, Mark de, Lechner, Anita, Schmidt, Reinhold, Heuvel, Martijn van den, Grond, Jeroen van der, Rombouts, Serge A.R.B.
Magazine: Neuroimage
Titel: Structural Covariance Networks and Their Association with Age, Features of Cerebral Small-Vessel Disease, and Cognitive Functioning in Older Persons
Auteur: Foster-Dingley, Jessica C., Hafkemeijer, Anne, van den Berg-Huysmans, Anne A., Moonen, Justine E.F., de Ruijter, Wouter, de Craen, Anton J.M., van der Mast, Roos C., Rombouts, Serge A.R.B., van der Grond, Jeroen
Magazine: Brain Connectivity
Titel: A comprehensive analysis of resting state fMRI measures to classify individual patients with Alzheimer's disease
Auteur: de Vos, Frank, Koini, Marisa, Schouten, Tijn M., Seiler, Stephan, van der Grond, Jeroen, Lechner, Anita, Schmidt, Reinhold, de Rooij, Mark, Rombouts, Serge A.R.B.
Magazine: Neuroimage
Titel: Longitudinal multimodal MRI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia
Auteur: Lize C Jiskoot, Jessica L Panman, Lieke H Meeter, Elise G P Dopper, Laura Donker Kaat, Sanne Franzen, Emma L van der Ende, Rick van Minkelen, Serge A R B Rombouts, Janne M Papma, John C van Swieten
Magazine: Brain
Titel: Diminished Posterior Precuneus Connectivity with the Default Mode Network Differentiates Normal Aging from Alzheimer's Disease
Auteur: Klaassens, Bernadet L., van Gerven, Joop M. A., van der Grond, Jeroen, de Vos, Frank, Möller, Christiane, Rombouts, Serge A. R. B.
Magazine: Frontiers in Aging Neuroscience
Titel: Combining anatomical, diffusion, and resting state functional magnetic resonance imaging for individual classification of mild and moderate Alzheimer's disease
Auteur: Schouten, Tijn M., Koini, Marisa, de Vos, Frank, Seiler, Stephan, van der Grond, Jeroen, Lechner, Anita, Hafkemeijer, Anne, Möller, Christiane, Schmidt, Reinhold, de Rooij, Mark, Rombouts, Serge A.R.B.
Magazine: Neuroimage Clinical
Titel: Grey-matter network disintegration as predictor of cognitive and motor function with aging
Auteur: Marisa Koini, Marco Duering, Benno G. Gesierich, Serge A. R. B. Rombouts, Stefan Ropele, Fabian Wagner, Christian Enzinger, Reinhold Schmidt
Magazine: Brain Structure and Function
Titel: Cognition and gray and white matter characteristics of presymptomatic C9orf72 repeat expansion
Auteur: Papma, Janne M., Jiskoot, Lize C., Panman, Jessica L., Dopper, Elise G., den Heijer, Tom, Donker Kaat, Laura, Pijnenburg, Yolande A.L., Meeter, Lieke H., van Minkelen, Rick, Rombouts, Serge A.R.B., van Swieten, John C.
Magazine: Neurology
Titel: Early grey matter changes in structural covariance networks in Huntington's disease
Auteur: Coppen, Emma M., van der Grond, Jeroen, Hafkemeijer, Anne, Rombouts, Serge A.R.B., Roos, Raymund A.C
Magazine: Neuroimage Clinical
Titel: Combining multiple anatomical MRI measures improves Alzheimer's disease classification
Auteur: de Vos, Frank, Schouten, Tijn M., Hafkemeijer, Anne, Dopper, Elise G. P., van Swieten, John C., de Rooij, Mark, van der Grond, Jeroen, Rombouts, Serge A. R. B.
Magazine: Human Brain Mapping
Titel: Resting-state functional MR imaging: a new window to the brain.
Auteur: Barkhof F, Haller S, Rombouts SA.
Magazine: Radiology
Titel: Neurofilament light chain: a biomarker for genetic frontotemporal dementia
Auteur: Meeter, Lieke H., Dopper, Elise G., Jiskoot, Lize C., Sanchez-Valle, Raquel, Graff, Caroline, Benussi, Luisa, Ghidoni, Roberta, Pijnenburg, Yolande A., Borroni, Barbara, Galimberti, Daniela, Laforce, Robert Jr, Masellis, Mario, Vandenberghe, Rik, Ber, Isabelle Le, Otto, Markus, van Minkelen, Rick, Papma, Janne M., Rombouts, Serge A., Balasa, Mircea, Öijerstedt, Linn, Jelic, Vesna, Dick, Katrina M., Cash, David M., Harding, Sophie R., Jorge Cardoso, M., Ourselin, Sebastien, Rossor, Martin N., Pa
Magazine: Annals of Clinical and Translational Neurology
Titel: Presymptomatic white matter integrity loss in familial frontotemporal dementia in the GENFI cohort: A cross-sectional diffusion tensor imaging study
Auteur: Lize C. Jiskoot, Martina Bocchetta, Jennifer M. Nicholas, David M. Cash, David Thomas, Marc Modat, Sebastien Ourselin, Serge A.R.B. Rombouts, Elise G.P. Dopper, Lieke H. Meeter, Jessica L. Panman, Rick van Minkelen, Emma L. van der Ende, Laura Donker Kaat, Yolande A.L. Pijnenburg, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B. Frisoni, Robert Laforce, Jr, Elizabeth Finger, Alexandre de Mendonça, Sandro S
Magazine: Annals of Clinical and Translational Neurology
Titel: Diminished Posterior Precuneus Connectivity with the Default Mode Network Differentiates Normal Aging from Alzheimer's Disease
Auteur: Klaassens, Bernadet L., van Gerven, Joop M. A., van der Grond, Jeroen, de Vos, Frank, Möller, Christiane, Rombouts, Serge A. R. B.
Magazine: Frontiers in Aging Neuroscience
Titel: Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.
Auteur: Rohrer JD, Nicholas JM, Cash DM, van Swieten J, Dopper E, Jiskoot L, van Minkelen R, Rombouts SA, Cardoso MJ, Clegg S, Espak M, Mead S, Thomas DL, De VitaE, Masellis M, Black SE, Freedman M, Keren R, MacIntosh BJ, Rogaeva E, Tang-Wai D, Tartaglia MC, Laforce R Jr, Tagliavini F, Tiraboschi P, Redaelli V, Prioni S, Grisoli M, Borroni B, Padovani A, Galimberti D, Scarpini E, Arighi A, Fumagalli G, Rowe JB, Coyle-Gilchrist I, Graff C, Fallström M, Jelic V, Ståhlbom AK, Andersson C, Thonberg H, Li
Magazine: Lancet Neurology
Titel: Catecholaminergic Neuromodulation Shapes Intrinsic MRI Functional Connectivity in the Human Brain
Auteur: van den Brink, R. L., Pfeffer, T., Warren, C. M., Murphy, P. R., Tona, K.-D., van der Wee, N. J. A., Giltay, E., van Noorden, M. S., Rombouts, S. A. R. B., Donner, T. H., Nieuwenhuis, S.
Magazine: Journal of Neuroscience
Titel: Detection of mild cognitive impairment in a community-dwelling population using quantitative, multiparametric MRI-based classification
Auteur: Mark J. R. J. Bouts, Jeroen van der Grond, Meike W. Vernooij, Marisa Koini, Tijn M. Schouten, Frank de Vos, Rogier A. Feis, Lotte G. M. Cremers, Anita Lechner, Reinhold Schmidt, Mark de Rooij, Wiro J. Niessen, M. Arfan Ikram, Serge A. R. B. Rombouts
Magazine: Human Brain Mapping
Titel: Bias Introduced by Multiple Head Coils in MRI Research: An 8 Channel and 32 Channel Coil Comparison
Auteur: Jessica L. Panman, Yang Yang To, Emma L. van der Ende, Jackie M. Poos, Lize C. Jiskoot, Lieke H. H. Meeter, Elise G. P. Dopper, Mark J. R. J. Bouts, Matthias J. P. van Osch, Serge A. R. B. Rombouts, John C. van Swieten, Jeroen van der Grond, Janne M. Papma, Anne Hafkemeijer
Magazine: Frontiers Neuroscience
Titel: Longitudinal resting state fMRI analysis in healthy controls and pre manifest Huntington's disease gene carriers: a three-year follow-up study.
Auteur: Odish OF, van den Berg-Huysmans AA, van den Bogaard SJ, Dumas EM, Hart EP, Rombouts SA, van der Grond J, Roos RA
Magazine: Human Brain Mapping
Titel: Pre-trained MRI-based Alzheimer's disease classification models to classify memory clinic patients
Auteur: Frank de Vos, Tijn M. Schouten, Marisa Koini, Mark J.R.J. Bouts, Rogier A. Feis, Anita Lechner, Reinhold Schmidt, Mark A. van Buchem, Frans R.J. Verhey, Marcel G.M. Olde Rikkert, Philip Scheltens, Mark de Rooij, Jeroen van der Grond, Serge A.R.B. Rombouts
Magazine: Neuroimage Clinical
Titel: Cerebral amyloid angiopathy is associated with decreased functional brain connectivity
Auteur: Nadieh Drenth, Jeroen van der Grond, Serge A.R.B. Rombouts, Mark A. van Buchem, Gisela M. Terwindt, Marieke J.H. Wermer, Jasmeer P. Chhatwal, M. Edip Gurol, Steven M. Greenberg, Sanneke van Rooden
Magazine: Neuroimage Clinical
Link: https://www.sciencedirect.com/science/article/pii/S2213158220303831?via%3Dihub
Titel: Associations between age and gray matter volume in anatomical brain networks in middle-aged to older adults.
Auteur: Hafkemeijer A, Altmann-Schneider I, de Craen AJ, Slagboom PE, van der Grond J, Rombouts SA.
Magazine: Aging Cell
Titel: Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease
Auteur: Rogier A. Feis, Mark J. R. J. Bouts, Elise G. P. Dopper, Nicola Filippini, Verena Heise, Aaron J. Trachtenberg, John C. van Swieten, Mark A. van Buchem, Jeroen van der Grond, Clare E. Mackay, Serge A. R. B. Rombouts
Magazine: BMC Neurology
Titel: Anterior cingulate cortex grey matter volume abnormalities in adolescents with PTSD after childhood sexual abuse
Auteur: Rinne-Albers, Mirjam A., Pannekoek, J. Nienke, van Hoof, Marie-José, van Lang, Natasja D., Lamers-Winkelman, Francien, Rombouts, Serge A., van der Wee, Nic J., Vermeiren, Robert R.
Magazine: European Neuropsychopharmacology
Titel: Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease.
Auteur: Hafkemeijer A, Möller C, Dopper EG, Jiskoot LC, Schouten TM, van Swieten JC, van der Flier WM, Vrenken H, Pijnenburg YA, Barkhof F, Scheltens P, van der Grond J, Rombouts SA.
Magazine: Frontiers in Human Neuroscience
Titel: Classification using fractional anisotropy predicts conversion in genetic frontotemporal dementia, a proof of concept
Auteur: Rogier A Feis, Jeroen van der Grond, Mark J R J Bouts, Jessica L Panman, Jackie M Poos, Tijn M Schouten, Frank de Vos, Lize C Jiskoot, Elise G P Dopper, Mark A van Buchem, John C van Swieten, Serge A R B Rombouts
Magazine: Brain Communications
Titel: Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI
Auteur: Rogier A. Feis, Mark J.R.J. Bouts, Jessica L. Panman, Lize C. Jiskoot, Elise G.P. Dopper, Tijn M. Schouten, Frank de Vos, Jeroen van der Grond, John C. van Swieten, Serge A.R.B. Rombouts
Magazine: Neuroimage Clinical
Titel: Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: A longitudinal arterial spin labeling study
Auteur: Dopper, Elise G.P., Chalos, Vicky, Ghariq, Eidrees, den Heijer, Tom, Hafkemeijer, Anne, Jiskoot, Lize C., de Koning, Inge, Seelaar, Harro, van Minkelen, Rick, van Osch, Matthias J.P., Rombouts, Serge A.R.B., van Swieten, John C.
Magazine: Neuroimage Clinical
Titel: Multiple Approaches to Diffusion Magnetic Resonance Imaging in Hereditary Cerebral Amyloid Angiopathy Mutation Carriers
Auteur: Tijn M. Schouten, Frank de Vos, Sanneke van Rooden, Mark J. R. J. Bouts, Anna M. van Opstal, Rogier A. Feis, Gisela M. Terwindt, Marieke J. H. Wermer, Mark A. van Buchem, Steven M. Greenberg, Mark de Rooij, Serge A. R. B. Rombouts, Jeroen van der Grond
Magazine: Journal of the American Heart Association
Titel: Structural and functional brain connectivity in pre symptomatic familial frontotemporal dementia.
Auteur: Dopper EG, Rombouts SA, Jiskoot LC, den Heijer T, de Graaf JR, de Koning I, Hammerschlag AR, Seelaar H, Seeley WW, Veer IM, van Buchem MA, Rizzu P, van Swieten JC.
Magazine: Neurology
Titel: A Longitudinal Study on Resting State Functional Connectivity in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease
Auteur: Hafkemeijer, Anne, Möller, Christiane, Dopper, Elise G.P., Jiskoot, Lize C., van den Berg-Huysmans, Annette A., van Swieten, John C., van der Flier, Wiesje M., Vrenken, Hugo, Pijnenburg, Yolande A.L., Barkhof, Frederik, Scheltens, Philip, van der Grond, Jeroen, Rombouts, Serge A.R.B.
Magazine: Journal of Alzheimer's disease
Titel: Advances in Targeted Therapies, Athens, Greece: Functional Brain Imaging.
Auteur: Serge Rombouts.
Titel: The International Headache Academy (iHead), Leiden, Netherlands: Resting State MRI to dissect brain network interactions.
Auteur: Serge Rombouts.
Titel: Resting state FMRI. ESMRMB School of MRI. Barcelona, 2016.
Auteur: Serge Rombouts.
Titel: Functional brain imaging in aging, dementia and pharmacology. Graz University 2015.
Auteur: Serge Rombouts.
Titel: Imaging Brain Networks in Cognitive Disorders. VASCOG 2016, Amsterdam.
Auteur: Serge Rombouts
Titel: January 30, 2014: Best practices in Statistical Data Analysis, international symposium, Leiden, Netherlands: FMRI of the Brain.
Auteur: Serge Rombouts.
Titel: Neuroimaging biomarkers in genetic frontotemporal dementia: towards a timely diagnosis.
Auteur: Rogier Feis
Titel: Classification and early detection of dementia and cognitive decline with magnetic resonance imaging
Auteur: Tijn Schouten

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