Identification of dietary modulators of cognitive ageing and brain plasticity and proof of concept of efficacy for preventing/reversing cognitive decline.
Understanding how diet modifies cognitive ageing represents the next frontiers for developing prevention strategies. A key may rely on elucidating the exact combination of dietary bioactives capable of modulating cognitive decline via brain plasticity, a major compensatory mechanism to maintain cognitive function. Another important question is the sensitive population in which such nutritional intervention should be undertaken. We hypothesized that (i) there exists a combination of dietary bioactives capable of modulating cognition and brain plasticity, (ii) dietary modulation of brain plasticity and cognition start in early-life and occurs throughout life and (iii) exposure to stress/genetic predisposition are vulnerability factors to consider.
We carried out a translational project across nutrition, epidemiology, and neurosciences leveraging human data/serum samples and mouse models and using innovative approaches of: (i) dietary exposure assessment (the food metabolome), (ii) human brain plasticity (in vitro parabiosis to assess neurogenesis and microglial function, lipidomics to assess neuronal integrity), and (iii) cognitive ageing modeling (early-life stress mouse model).
D-CogPlast started with a discovery stage in humans, identifying a set of dietary bioactives from the food metabolome associated with cognitive decline, along with vulnerable populations, in 200 individuals with accelerated cognitive decline over 13+ years against 200 individuals with preserved cognition. This was validated in 400 participants from a separate cohort. The second investigated the ability of the identified set of bioactives predictive of cognitive decline to modulate brain plasticity and neuronal integrity. The third stage consisted in a proof-of-principle dietary intervention with identified bioactives in a mouse model of cognitive decline.
On completion of this project we have (i) identified dietary compounds providing protective effect against cognitive ageing and brain plasticity alteration, (ii) identified vulnerable populations responding to the impact of diet on cognitive decline, (iii) provided evidence of brain plasticity as targets of choice for bioactives intervention to prevent/slowdown cognitive decline and (iv) provided a proof-of-principle life-long dietary intervention for preventing/rescuing cognitive decline. It is expected that the bioactives identified and validated could lead to dietary interventions and recommendations for cognitive decline prevention.
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Auteur: A Korosi
Auteur: A Korosi
Auteur: A Korosi
Auteur: A Korosi
Auteur: A Korosi
Auteur: A Korosi
Auteur: Yam, K.Y., Naninck, E.F.G., Abbink, M.R., la Fleur, S.E., Schipper, L., van den Beukel, J.C., Grefhorst, A., Oosting, A., van der Beek, E.M., Lucassen, P.J., Korosi, A.
Magazine: Psychoneuroendocrinology
Auteur: Miquel, Sophie, Champ, Claire, Day, Jon, Aarts, Esther, Bahr, Ben A., Bakker, Martijntje, Bánáti, Diána, Calabrese, Vittorio, Cederholm, Tommy, Cryan, John, Dye, Louise, Farrimond, Jonathan A., Korosi, Aniko, Layé, Sophie, Maudsley, Stuart, Milenkovic, Dragan, Mohajeri, M.Hasan, Sijben, John, Solomon, Alina, Spencer, Jeremy P.E., Thuret, Sandrine, Vanden Berghe, Wim, Vauzour, David, Vellas, Bruno, Wesnes, Keith, Willatts, Peter, Wittenberg, Raphael, Geurts, Lucie
Magazine: Ageing Research Reviews
Auteur: Hoeijmakers, Lianne, Ruigrok, Silvie R., Amelianchik, Anna, Ivan, Daniela, van Dam, Anne-Marie, Lucassen, Paul J., Korosi, Aniko
Magazine: Brain, Behavior, and Immunity
Auteur: Naninck, Eva F. G., Oosterink, J. Efraim, Yam, Kit-Yi, de Vries, Lennart P., Schierbeek, Henk, van Goudoever, Johannes B., Verkaik-Schakel, Rikst-Nynke, Plantinga, Josèe A., Plosch, Torsten, Lucassen, Paul J., Korosi, Aniko
Magazine: The FASEB Journal
Auteur: Abbink, M. R., Naninck, E. F. G., Lucassen, P. J., Korosi, A.
Magazine: Hippocampus
Auteur: Hoeijmakers, Lianne, Meerhoff, Gideon F., de Vries, Janneke W., Ruigrok, Silvie R., van Dam, Anne-Marie, van Leuven, Fred, Korosi, Aniko, Lucassen, Paul J.
Magazine: Neurobiology of Aging
Auteur: Yam, K.Y., Ruigrok, S.R., Ziko, I., De Luca, S.N., Lucassen, P.J., Spencer, S.J., Korosi, A.
Magazine: Psychoneuroendocrinology
Auteur: Lucassen, P. J., Korosi, A., Krugers, H. J. & Oomen, C. A.