Influence of maternal preconception and early-pregnancy health on pregnancy and offspring outcomes. From risk selection to interventions in multi-ethnic populations

Generation R Next: Invloed van preconceptiezorg op zwangerschap en geboorte uitkomsten

Vraagstuk

Het vroege leven is al zeer belangrijk voor onze gezondheid later in het leven. Steeds meer onderzoek laat zien dat de vroege zwangerschap, en zelfs al de preconceptieperiode, belangrijke perioden zijn voor geboorte-uitkomsten en latere gezondheid.

Onderzoek en verwachte uitkomst

Dit project is gericht op de ontwikkeling van preventiestrategieën gericht op het verbeteren van de leefstijl en het verminderen van stress van toekomstige ouders, al vanaf de preconceptieperiode, om het verloop van de zwangerschap, geboorte-uitkomsten en de gezondheid van hun kinderen te verbeteren. Dit project zal worden uitgevoerd binnen het Generation R Next onderzoek, een groot onderzoek in Rotterdam vanaf de preconceptieperiode gericht op toekomstige ouders en hun kinderen. Voor het project zullen we nauw samenwerken met het Rotterdams Centrum voor Zwangerschap & Kind, het ZonMw Regionaal Consortium Zwangerschap & Geboorte Zuidwest Nederland en de gemeente Rotterdam.

Meer over preconceptiezorg

Producten

Titel: Population screening for gestational hypertensive disorders using maternal, fetal and placental characteristics: A population-based prospective cohort study
Auteur: Jan S Erkamp, Vincent W V Jaddoe, Liesbeth Duijts, Irwin K M Reiss, Annemarie G M G J Mulders, Eric A P Steegers, Romy Gaillard
Magazine: Prenatal Diagnosis
Begin- en eindpagina: 746-757
Titel: Maternal Glucose Concentrations in Early Pregnancy and Cardiometabolic Risk Factors in Childhood
Auteur: Rama J Wahab, Ellis Voerman, Pauline W Jansen, Edwin H G Oei, Eric A P Steegers, Vincent W V Jaddoe, Romy Gaillard
Magazine: Obesity
Begin- en eindpagina: 985-993
Titel: Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study
Auteur: Poeran-Bahadoer S, Jaddoe VWV, Gishti O, Grooten IJ, Franco OH, Hofman A, Steegers EAP, Gaillard R
Magazine: Journal of Developmental Origin of Health and Disease
Begin- en eindpagina: 118-126
Titel: Associations of maternal caffeine intake during pregnancy with abdominal and liver fat deposition in childhood
Auteur: Voerman E, Jaddoe VW, Hulst ME, Oei EH, Gaillard R
Magazine: International Journal of Pediatric Obesity
Begin- en eindpagina: 1-10
Titel: Associations Between Intake of Sugar-Containing Beverages in Infancy With Liver Fat Accumulation at School Age
Auteur: Geurtsen ML, Santos S, Gaillard R, Felix JF, Jaddoe VWV.
Magazine: Hepatology
Begin- en eindpagina: 560-570
Titel: Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births
Auteur: Elise M Philips , Susana Santos, Leonardo Trasande, Juan J Aurrekoetxea, Henrique Barros, Andrea von Berg, Anna Bergström, Philippa K Bird, Sonia Brescianini, Carol Ní Chaoimh, Marie-Aline Charles, Leda Chatzi, Cécile Chevrier, George P Chrousos, Nathalie Costet, Rachel Criswell, Sarah Crozier, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Marleen M H J van Gelder, Vagelis Georgiu, Keith M Godfrey, Davide Gori, Wojciech Hanke, Barbara Heude, Daniel Hryhorczuk, Carmen
Magazine: PLoS Medicine
Begin- en eindpagina: 1-25
Titel: Influence of genetic variants for birth weight on fetal growth and placental haemodynamics
Auteur: Vermeulen MJ, Gaillard R, Miliku K, Reiss I, Steegers EAP, Jaddoe V, Felix J.
Magazine: Archives of Disease in Childhood - Fetal and Neonatal Edition
Begin- en eindpagina: 393-398
Titel: Smoking cessation in early-pregnancy, gestational weight gain and subsequent risks of pregnancy complications.
Auteur: Al-Hassany L, Wahab RJ, Steegers EAP, Jaddoe VWV, Gaillard
Magazine: European Journal of Obstetrics & Gynecology and Reproductive Biology
Begin- en eindpagina: 7-14
Titel: Second and third trimester fetal ultrasound population screening for risks of preterm birth and small-size and large-size for gestational age at birth: a population-based prospective cohort study
Auteur: Jan S Erkamp, Ellis Voerman, Eric A P Steegers, Annemarie G M G J Mulders, Irwin K M Reiss, Liesbeth Duijts, Vincent W V Jaddoe, Romy Gaillard
Magazine: BMC Medicine
Begin- en eindpagina: 1-12
Titel: Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
Auteur: LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group; Ellis Voerman, Susana Santos, Hazel Inskip, Pilar Amiano, Henrique Barros, Marie-Aline Charles, Leda Chatzi, George P Chrousos, Eva Corpeleijn, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Vagelis Georgiu, Davide Gori, Wojciech Hanke, Irva Hertz-Picciotto, Barbara Heude, Marie-France Hivert, Daniel Hryhorczuk, Carmen Iñiguez, Anne M Karvonen, Leanne K Küpers, Hanna Lags
Magazine: JAMA Network Open
Begin- en eindpagina: 1702-1715
Titel: Associations of maternal and infant metabolite profiles with foetal growth and the odds of adverse birth outcomes.
Auteur: Voerman E, Jaddoe VWV, Shokry E, Ruijter GJG, Felix JF, Koletzko B, Gaillard R
Magazine: International Journal of Pediatric Obesity
Begin- en eindpagina: 1-11
Titel: Customized versus population birth weight charts for identification of newborns at risk of long-term adverse cardio-metabolic and respiratory outcomes: a population-based prospective cohort study
Auteur: Jan S Erkamp, Vincent W V Jaddoe, Annemarie G M G J Mulders, Eric A P Steegers, Irwin K M Reiss, Liesbeth Duijts, Romy Gaillard
Magazine: BMC Medicine
Begin- en eindpagina: 1-12
Titel: Associations of Maternal Glycemia in the First Half of Pregnancy With Alterations in Cardiac Structure and Function in Childhood
Auteur: Rama J Wahab, Vincent W V Jaddoe, Arno A W Roest, Liza Toemen, Romy Gaillard
Magazine: Diabetes Care
Begin- en eindpagina: 2272-2280
Titel: Maternal early pregnancy dietary glycemic index and load, fetal growth, and the risk of adverse birth outcomes
Auteur: Rama J Wahab, Judith M Scholing, Romy Gaillard
Magazine: European Journal of Nutricion
Begin- en eindpagina: 1-11
Titel: Associations of maternal age at the start of pregnancy with placental function throughout pregnancy: The Generation R Study.
Auteur: Erkamp JS, Jaddoe VWV, Mulders AGMGJ, Duijts L, Reiss IKM, Steegers EAP, Gaillard R.
Magazine: European Journal of Obstetrics & Gynecology and Reproductive Biology
Begin- en eindpagina: 53-59
Titel: Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium.
Auteur: Chen LW, Aubert AM, Shivappa N, Bernard JY, Mensink-Bout SM, Geraghty AA, Mehegan J, Suderman M, Polanska K, Hanke W, Jankowska A, Relton CL, Crozier SR, Harvey NC, Cooper C, Hanson M, Godfrey KM, Gaillard R, Duijts L, Heude B, Hébert JR, McAuliffe FM, Kelleher CC, Phillips CM.
Magazine: BMC Medicine
Begin- en eindpagina: 33-33
Titel: Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
Auteur: LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group; Ellis Voerman, Susana Santos, Hazel Inskip, Pilar Amiano, Henrique Barros, Marie-Aline Charles, Leda Chatzi, George P Chrousos, Eva Corpeleijn, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Vagelis Georgiu, Davide Gori, Wojciech Hanke, Irva Hertz-Picciotto, Barbara Heude, Marie-France Hivert, Daniel Hryhorczuk, Carmen Iñiguez, Anne M Karvonen, Leanne K Küpers, Hanna Lags
Magazine: JAMA
Begin- en eindpagina: 1702-1715
Titel: Associations of maternal early-pregnancy dietary glycemic index with childhood general, abdominal and ectopic fat accumulation.
Auteur: Wahab RJ, Jaddoe VWV, Gaillard R.
Magazine: Clinical Nutrition
Begin- en eindpagina: 1628-1636
Titel: High maternal early-pregnancy blood glucose levels are associated with altered fetal growth and increased risk of adverse birth outcomes
Auteur: Geurtsen ML, van Soest EEL, Voerman E, Steegers EAP, Jaddoe VWV, Gaillard R
Magazine: Diabetologia
Begin- en eindpagina: 1880-1890
Titel: Associations of maternal metabolic profile with placental and fetal cerebral and cardiac hemodynamics
Auteur: Kooijman MN, Jaddoe VWV, Steegers EAP, Gaillard R
Magazine: European Journal of Obstetrics & Gynecology and Reproductive Biology
Begin- en eindpagina: 51-58
Titel: Ethnic differences in childhood right and left cardiac structure and function assessed by cardiac magnetic resonance imaging.
Auteur: van Genuchten WJ, Toemen L, Roest AAW, Vernooij MW, Gaillard R, Helbing WA, Jaddoe VWV
Magazine: European Journal of Pediatrics
Begin- en eindpagina: 1257-1266
Titel: Maternal Phthalate and Bisphenol Urine Concentrations during Pregnancy and Early Markers of Arterial Health in Children
Auteur: Blaauwendraad SM, Gaillard R, Santos S, Sol CM, Kannan K, Trasande L, Jaddoe VWV.
Magazine: Environmental Health Perspectives
Begin- en eindpagina: 47007-47007
Titel: The Cardiovascular Stress Response as Early Life Marker of Cardiovascular Health: Applications in Population-Based Pediatric Studies-A Narrative Review
Auteur: Meddy N Bongers-Karmaoui, Vincent W V Jaddoe, Arno A W Roest, Romy Gaillard
Magazine: Pediatric cardiology
Begin- en eindpagina: 1-17
Titel: Associations of DASH Diet in Pregnancy With Blood Pressure Patterns, Placental Hemodynamics, and Gestational Hypertensive Disorders.
Auteur: Wiertsema CJ, Mensink-Bout SM, Duijts L, Mulders AGMGJ, Jaddoe VWV, Gaillard R
Magazine: Journal of the American Heart Association
Begin- en eindpagina: 1-40
Titel: Associations of dietary glycemic index and load during pregnancy with blood pressure, placental hemodynamic parameters and the risk of gestational hypertensive disorders
Auteur: Wiertsema CJ, Wahab RJ, Mulders AGMGJ, Gaillard R.
Magazine: European Journal of Nutricion
Begin- en eindpagina: 1-14
Titel: Associations of Maternal Early-Pregnancy Glucose Concentrations With Placental Hemodynamics, Blood Pressure, and Gestational Hypertensive Disorders
Auteur: Erkamp JS, Geurtsen ML, Duijts L, Reiss IKM, Mulders AGMGJ, Steegers EAP, Gaillard R, Jaddoe VWV
Magazine: American Journal of Hypertension
Begin- en eindpagina: 660-669
Titel: Maternal First-Trimester Cow-Milk Intake Is Positively Associated with Childhood General and Abdominal Visceral Fat Mass and Lean Mass but Not with Other Cardiometabolic Risk Factors at the Age of 10 Years
Auteur: Voerman E, Gaillard R, Geurtsen ML, Jaddoe VWV.
Magazine: Journal of Nutrition
Begin- en eindpagina: 1965-1975
Titel: Maternal body mass index, early-pregnancy metabolite profile and birthweight.
Auteur: Wahab RJ, Jaddoe VWV, Voerman E, Ruijter GJG, Felix JF, Marchioro L, Uhl O, Shokry E, Koletzko B, Gaillard R.
Magazine: Journal of Clinical Endocrinology & Metabolism
Begin- en eindpagina: 1-13
Titel: Maternal Early-Pregnancy Glucose Concentrations and Liver Fat Among School-Age Children.
Auteur: Geurtsen ML, Wahab RJ, Felix JF, Gaillard R, Jaddoe VWV
Magazine: Hepatology
Begin- en eindpagina: 1902-1913
Titel: Associations of maternal bisphenol urine concentrations during pregnancy with neonatal metabolomic profiles.
Auteur: Blaauwendraad SM, Voerman E, Trasande L, Kannan K, Santos S, Ruijter GJG, Sol CM, Marchioro L, Shokry E, Koletzko B, Jaddoe VWV, Gaillard R
Magazine: Metabolomics
Begin- en eindpagina: 1-16
Titel: Associations of fetal and infant growth patterns with early markers of arterial health in school-aged children.
Auteur: Gonçalves, R., Wiertsema, C.J., Silva, C.C.V., Monasso, G.S., Gaillard, R., Steegers, E.A.P., Santos, S., Jaddoe, V.W.V.
Magazine: JAMA Network Open
Begin- en eindpagina: 1-13
Titel: Prediction of healthy pregnancy outcomes in women with overweight and obesity: The role of maternal early-pregnancy metabolites
Auteur: Rama J Wahab, Vincent W V Jaddoe, Romy Gaillard
Magazine: Metabolites
Begin- en eindpagina: 1-14
Titel: Associations of maternal Angiogenic factors during pregnancy with childhood carotid intimamedia thickness and blood pressure.
Auteur: Meddy N Bongers-Karmaoui, Vincent W V Jaddoe, Romy Gaillard
Magazine: Atherosclerosis
Begin- en eindpagina: 46-54
Titel: Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age.
Auteur: Monasso GS, Felix JF, Heil SG, de Rijke YB, Gaillard R, Jaddoe VWV
Magazine: Clinical Nutrition
Begin- en eindpagina: 5133-5140
Titel: Maternal Iron Status in Early Pregnancy and Blood Pressure Throughout Pregnancy, Placental Hemodynamics and the Risk of Gestational Hypertensive Disorders
Auteur: Taeubert MJ, Wiertsema CJ, Vermeulen MJ, Quezada-Pinedo HG, Reiss IK, Muckenthaler MU, Gaillard R.
Magazine: Journal of Nutrition
Begin- en eindpagina: 1-31

Onderwerpen

Zwanger

Kenmerken

Projectnummer:
543003109
Looptijd: 100%
2018
2023
Gerelateerde programma's:
Gerelateerde subsidieronde:
Zwangerschap en geboorte: preventie, gezondheidsbevordering, zorginterventies en organisatie integrale geboortezorg
Projectleider en penvoerder:
dr. R. Gaillard MD PhD
Verantwoordelijke organisatie:
Erasmus Medisch Centrum