Intercepting Cancer''s Mail, how extracellular vesicles micro-manage the secretome
In celbiologie werken receptor-ligand interacties als ‘een sleutel in een slot’. De ‘sleutels’ (liganden) zweven echter niet vrij rond. Ze worden in hun vrijheid belemmerd door ‘sleutelbossen’ (decoys). Ik zal de rol van deze moleculaire sleutelbossen onderzoeken in celmigratie, een proces dat fundamenteel is voor kankeruitzaaingen.
Producten
Titel: G protein-coupled receptors: a gateway to targeting oncogenic EVs?
Auteur: Lotte Di Niro, Amber C Linders, Thomas Glynn, D Michiel Pegtel, Marco Siderius, Caitrin Crudden, Martine J Smit
Magazine: Extracellular Vesicles and Circulating Nuceic Acids
Begin- en eindpagina: 233-248
Link: https://www.oaepublish.com/articles/evcna.2024.10
Auteur: Lotte Di Niro, Amber C Linders, Thomas Glynn, D Michiel Pegtel, Marco Siderius, Caitrin Crudden, Martine J Smit
Magazine: Extracellular Vesicles and Circulating Nuceic Acids
Begin- en eindpagina: 233-248
Link: https://www.oaepublish.com/articles/evcna.2024.10
Titel: Chemokine and opioid peptide scavenging through constitutive and ligand-induced release of ACKR3-bearing extracellular vesicles
Auteur: Christie B. Palmer, Lucie Rospape, Max Meyrath, Caitrín Crudden, Manuel Counson, Anne-Katrin, Lotte Di Niro, Ana Alonso Bartolome, Cláudio Pinheiro, Vanessa Klapp, Ester Cassano, Stéphane A. Laporte, Stephen J. Hill, Julia Drube, Carsten Hoffmann, Rob Leurs, Michel Bouvier, Meinrad P. Gawaz, An Hendrix, Etienne Moussay, Martine J. Smit, Jérôme Paggetti, Martyna Szpakowska, Andy Chevigné
Magazine: bioRxiv
Link: https://doi.org/10.64898/2026.06.18.733119
Auteur: Christie B. Palmer, Lucie Rospape, Max Meyrath, Caitrín Crudden, Manuel Counson, Anne-Katrin, Lotte Di Niro, Ana Alonso Bartolome, Cláudio Pinheiro, Vanessa Klapp, Ester Cassano, Stéphane A. Laporte, Stephen J. Hill, Julia Drube, Carsten Hoffmann, Rob Leurs, Michel Bouvier, Meinrad P. Gawaz, An Hendrix, Etienne Moussay, Martine J. Smit, Jérôme Paggetti, Martyna Szpakowska, Andy Chevigné
Magazine: bioRxiv
Link: https://doi.org/10.64898/2026.06.18.733119
Titel: Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms
Auteur: S. Mobach, N.D. Bergkamp, Z. Ma, M.V. Haselager, S.M. Anbuhl, D. Jurriens, J. van den Bor, Z. Wang, C. Crudden, J.L. Roos, C.V. Perez Almeria, R.A. Boergonje, M.J. Lohse, R. Bosma, E. Eldering, M. Siderius, W. Wu, M. Spaargaren, S.H. Tonino, A.P. Kater, M.J. Smit, & R. Heukers.
Magazine: PNAS
Link: https://doi.org/10.1073/pnas.2424186122
Auteur: S. Mobach, N.D. Bergkamp, Z. Ma, M.V. Haselager, S.M. Anbuhl, D. Jurriens, J. van den Bor, Z. Wang, C. Crudden, J.L. Roos, C.V. Perez Almeria, R.A. Boergonje, M.J. Lohse, R. Bosma, E. Eldering, M. Siderius, W. Wu, M. Spaargaren, S.H. Tonino, A.P. Kater, M.J. Smit, & R. Heukers.
Magazine: PNAS
Link: https://doi.org/10.1073/pnas.2424186122
Titel: Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies
Auteur: Claudia V. Perez Almeria, Omolade Otun, Roman Schlimgen, Thomas D. Lamme, Lotte Di Niro, Caitrin Crudden, Jan Paul Bebelman, Noureldine Youssef, Lejla Musli, Shawn Jenjak, Vladimir Bobkov, Julia Drube, Carsten Hoffmann, Brian F. Volkman, Sébastien Granier, Cherine Bechara, Marco Siderius, Raimond Heukers, Christopher T. Schafer & Martine J. Smit
Magazine: Nature Communications
Link: https://doi.org/10.1038/s41467-025-65858-x
Auteur: Claudia V. Perez Almeria, Omolade Otun, Roman Schlimgen, Thomas D. Lamme, Lotte Di Niro, Caitrin Crudden, Jan Paul Bebelman, Noureldine Youssef, Lejla Musli, Shawn Jenjak, Vladimir Bobkov, Julia Drube, Carsten Hoffmann, Brian F. Volkman, Sébastien Granier, Cherine Bechara, Marco Siderius, Raimond Heukers, Christopher T. Schafer & Martine J. Smit
Magazine: Nature Communications
Link: https://doi.org/10.1038/s41467-025-65858-x
Titel: Receptors on the Move; The Convergence of Extracellular Vesicle and GPCR biology
Auteur: Caitrin Crudden
Link: https://www.thisisathens.org/acvb/events-9-european-congress-pyharmacology-2024?
Auteur: Caitrin Crudden
Link: https://www.thisisathens.org/acvb/events-9-european-congress-pyharmacology-2024?
Titel: Receptors on the Move; The Convergence of Extracellular Vesicle and GPCR Biology
Auteur: Caitrin Crudden
Link: https://www.grc.org/molecular-pharmacology-conference/2023/
Auteur: Caitrin Crudden
Link: https://www.grc.org/molecular-pharmacology-conference/2023/
Titel: BSc Course; Engineering Mammalian Systems (5142ENMS6Y)
Link: https://datanose.nl/#course%5B137595%5D
Link: https://datanose.nl/#course%5B137595%5D