N3rvousSystem: A 3R systems biology strategy for human neurotoxicity hazard, risk and safety assessment

Ronde 2014 Internationaal (Innovative Systems Toxicology for Alternatives to Animal Testing): People are exposed to numerous chemicals via the environment. To prevent adverse health effects, risk and safety assessment are obligatory before chemicals are allowed on the market. The aim of this research project is the development of a strategy to detect adverse effects on the brain resulting from chemical exposure. The ultimate goal is to do this without experiments in animals. Therefore, a number of cell models are used. To evaluate whether these cellular assays reliably predict neurotoxicity, also a limited number of experiments are done to detect effects of exposure to chemicals on behaviour. Data from this research in combination with information from literature are combined in mathematical models to predict neurotoxicity in humans. It will be evaluated in which manner (which combination of experiments and methods) neurotoxicity is optimally predicted to improve risk and safety assessment. This will be actively communicated to societal, regulatory and governmental parties concerned.

Producten

Titel: Differential Effects of Organophosphate Insecticides and Their Metabolites on Neuronal Network Development and Function Assessed in Primary Rat Cortical Cultures Using Microelectrode Array (MEA) Recordings
Auteur: H. Heusinkveld and R. Westerink
Link: https://www.toxicology.org/application/ToxicologistDB/index.aspx
Titel: The organophosphates diazinon and chlorpyrifos disturb neuronal network function in rat primary cortical cultures
Auteur: Harm J. Heusinkveld, Anouk Peters, Remco H.S. Westerink
Link: https://www.toxicology.org/application/ToxicologistDB/index.aspx
Titel: Human Induced Pluripotent Stem Cell Models for In Vitro Neurotoxicity Testing
Auteur: "A. M. Tukker, F. M. Wijnolts, and R. H. Westerink
Link: https://www.toxicology.org/application/ToxicologistDB/index.aspx
Titel: N3RvousSystem
Auteur: R. Westerink
Titel: Integrated in vitro neurotoxicity testing
Auteur: H. Heusinkveld
Titel: Chronic 14-day exposure to insecticides or methylmercury modulates neuronal activity in primary rat cortical cultures
Auteur: Dingemans, Milou M.L., Schütte, Marijke G., Wiersma, Daphne M.M., de Groot, Aart, van Kleef, Regina G.D.M., Wijnolts, Fiona M.J., Westerink, Remco H.S.
Magazine: Neurotoxicology
Titel: Comparison of different in vitro cell models for the assessment of pesticide-induced dopaminergic neurotoxicity
Auteur: Heusinkveld, Harm J., Westerink, Remco H.S.
Magazine: Toxicology in Vitro

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Kenmerken

Projectnummer:
114027001
Looptijd: 100%
2015
2020
Gerelateerde programma's:
Gerelateerde subsidieronde:
Innovative Systems Toxicology for Alternatives to Animal Testing (InnoSysTox)
Projectleider en penvoerder:
Dr. H.J. Heusinkveld
Verantwoordelijke organisatie:
Universiteit Utrecht