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Neuroimaging and fluid biomarkers predicting conversion and disease progression in mutation carriers of genetic frontotemporal dementia.

Frontotemporale dementie (FTD) is een klinisch, pathologisch en genetisch heterogene neurodegeneratieve aandoening, die zich kenmerkt door veranderingen in het gedrag en de taal. In 30% van de gevallen wordt FTD veroorzaakt door een erfelijke afwijking. Familieleden van patiënten met deze erfelijke afwijking hebben daardoor 50% kans om FTD te ontwikkelen. Juist door deze personen te onderzoeken, is het mogelijk om de vroegste veranderingen in bloed en hersenvocht, op MRI-scans en bij cognitieve testen vast te leggen. Zo kan de ziekte beter worden vastgesteld en kan er ook een meer betrouwbare voorspelling worden gedaan over het begin van de ziekte.

Aanpak

In de FTD-RisCstudie volgen wij sinds 2010 een grote groep van FTD familieleden, door ieder jaar neuropsychologisch onderzoek, hersenscans (MRI), en afname van bloed en/of hersenvocht te herhalen.

Resultaten

In dit onderzoek hebben wij diverse vroege biomarkers voor FTD geïdentificeerd, die o.a. meer inzicht geven in het pathofysiologische ziekteproces, maar die ook van groot belang zijn voor de ontwikkeling van medicamenteuze behandelingen. Ze vormen een aanknopingspunt voor ziekte als klinische uitkomstmaten.

Meer informatie

Producten

Titel: Data-driven staging of genetic frontotemporal dementia using multi-modal MRI
Auteur: McCarthy J, Borroni B, Sanchez-Valle R, Moreno F, Laforce R Jr, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Butler C, Gerhard A, Danek A, Levin J, Otto M, Frisoni G, Ghidoni R, Sorbi S, Jiskoot LC, Seelaar H, van Swieten JC, Rohrer JD, Iturria-Medina Y, Ducharme S; GENetic Frontotemporal Dementia Initiative (GENFI).
Magazine: Human Brain Mapping
Titel: Presymptomatic white matter integrity loss in familial frontotemporal dementia in the GENFI cohort: A crosssectional diffusion tensor imaging study
Auteur: Lize C. Jiskoot1,2,3, Martina Bocchetta2 , Jennifer M. Nicholas2,4 , David M. Cash2,5, David Thomas2,5, Marc Modat2,5, Sebastien Ourselin2,5, Serge A.R.B. Rombouts3,6,7, Elise G.P. Dopper1 , Lieke H. Meeter1 , Jessica L. Panman1,3, Rick van Minkelen8 , Emma L. van der Ende1,3, Laura Donker Kaat1,9, Yolande A.L. Pijnenburg10, Barbara Borroni11, Daniela Galimberti12, Mario Masellis13, Maria Carmela Tartaglia14, James Rowe15, Caroline Graff16, Fabrizio Tagliavini17, Giovanni B. Frisoni18,19, Robert
Magazine: Annals of Clinical and Translational Neurology
Titel: Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling.
Auteur: Young AL, Bocchetta M, Russell LL, Convery RS, Peakman G, Todd E, Cash DM, Greaves CV, van Swieten J, Jiskoot L, Seelaar H, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Williams SCR, Alexander DC, Rohrer JD; Genetic FTD Initiative (GENFI).
Magazine: Neurology
Titel: A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study
Auteur: Bergström S, Öijerstedt L, Remnestål J, Olofsson J, Ullgren A, Seelaar H, van Swieten JC, Synofzik M, Sanchez-Valle R, Moreno F, Finger E, Masellis M, Tartaglia C, Vandenberghe R, Laforce R, Galimberti D, Borroni B, Butler CR, Gerhard A, Ducharme S, Rohrer JD, Månberg A, Graff C, Nilsson P; Genetic Frontotemporal Dementia Initiative (GENFI).
Magazine: Molecular neurodegeneration
Titel: A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia. Brain.
Auteur: van der Ende EL, Bron EE, Poos JM, Jiskoot LC, Panman JL, Papma JM, Meeter LH, Dopper EGP, Wilke C, Synofzik M, Heller C, Swift IJ, Sogorb-Esteve A, Bouzigues A, Borroni B, Sanchez-Valle R, Moreno F, Graff C, Laforce R, Galimberti D, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, Rowe JB, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Pijnenburg YAL, Sorbi S, Zetterberg H, Niessen WJ, Rohrer JD, Klein S, van Swieten JC, Venkatraghavan V,
Magazine: Brain
Titel: Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia
Auteur: Panman JL, Venkatraghavan V, van der Ende EL, Steketee RME, Jiskoot LC, Poos JM, Dopper EGP, Meeter LHH, Donker Kaat L, Rombouts SARB, Vernooij MW, Kievit AJA, Premi E, Cosseddu M, Bonomi E, Olives J, Rohrer JD, Sánchez-Valle R, Borroni B, Bron EE, Van Swieten JC, Papma JM, Klein S; GENFI consortium investigators.
Magazine: Journal of Neurology, Neurosurgery and Psychiatry
Titel: Unravelling the clinical spectrum and the role of repeat length in C9ORF72 repeat expansions
Auteur: van der Ende EL, Jackson JL, White A, Seelaar H, van Blitterswijk M, Van Swieten JC.
Magazine: Journal of Neurology, Neurosurgery and Psychiatry
Titel: Impaired Knowledge of Social Norms in Dementia and Psychiatric Disorders: Validation of the Social Norms Questionnaire-Dutch Version (SNQ-NL).
Auteur: van den Berg E, Poos JM, Jiskoot LC, Montagne B, Kessels RPC, Franzen S, van Hemmen J, Eikelboom WS, Heijboer EGC, de Kriek J, van der Vlist A, de Jong FJ, van Swieten JC, Seelaar H, Papma JM.
Magazine: Assessment
Titel: The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort
Auteur: Franklin HD, Russell LL, Peakman G, Greaves CV, Bocchetta M, Nicholas J, Poos J, Convery RS, Cash DM, van Swieten J, Jiskoot L, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Le Ber I, Pasquier F, Rohrer JD; Genetic FTD Initiative, GENFI.
Magazine: Alzheimer's research & therapy
Titel: Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population
Auteur: Poos JM, van den Berg E, Visch-Brink E, Eikelboom WS, Franzen S, van Hemmen J, Pijnenburg YAL, Satoer D, Dopper EGP, van Swieten JC, Papma JM, Seelaar H, Jiskoot LC
Magazine: Archives of Neurology
Titel: Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia.
Auteur: Shafiei G, Bazinet V, Dadar M, Manera AL, Collins DL, Dagher A, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Butler C, Gerhard A, Danek A, Levin J, Otto M, Sorbi S, Jiskoot LC, Seelaar H, van Swieten JC, Rohrer JD, Misic B, Ducharme S; Frontotemporal Lobar Degeneration Neuroimaging Initiative (FTLDNI); GENetic Frontotemporal dementia Initiative (GENFI).
Magazine: Brain
Titel: Cognitive composites for genetic frontotemporal dementia: GENFI-Cog
Auteur: Poos JM, Moore KM, Nicholas J, Russell LL, Peakman G, Convery RS, Jiskoot LC, van der Ende E, van den Berg E, Papma JM, Seelaar H, Pijnenburg YAL, Moreno F, Sanchez-Valle R, Borroni B, Laforce R, Masellis M, Tartaglia C, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tiraboschi P, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Otto M, Le Ber I, Pasquier F, van Swieten JC, Rohrer JD; Genetic FTD Initiative (GENFI).
Magazine: Alzheimer's research & therapy
Titel: Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration
Auteur: Rojas JC, Wang P, Staffaroni AM, Heller C, Cobigo Y, Wolf A, Goh SM, Ljubenkov PA, Heuer HW, Fong JC, Taylor JB, Veras E, Song L, Jeromin A, Hanlon D, Yu L, Khinikar A, Sivasankaran R, Kieloch A, Valentin MA, Karydas AM, Mitic LL, Pearlman R, Kornak J, Kramer JH, Miller BL, Kantarci K, Knopman DS, Graff-Radford N, Petrucelli L, Rademakers R, Irwin DJ, Grossman M, Ramos EM, Coppola G, Mendez MF, Bordelon Y, Dickerson BC, Ghoshal N, Huey ED, Mackenzie IR, Appleby BS, Domoto-Reilly K, Hsiung GR, To
Magazine: Neurology
Titel: Cognitive profiles discriminate between genetic variants of behavioral frontotemporal dementia
Auteur: J. M. Poos1,2 · L. C. Jiskoot1,3 · S. M. J. Leijdesdorff4 · H. Seelaar1 · J. L. Panman1,2 · E. L. van der Ende1 · M. O. Mol1 · L. H. H. Meeter1 · Y. A. L. Pijnenburg5 · L. Donker Kaat1,6 · F. J. de Jong1 · J. C. van Swieten1 · J. M. Papma1 · E. van den Berg1
Magazine: Journal of Neurology
Titel: An Automated Toolbox to Predict Single Subject Atrophy in Presymptomatic Granulin Mutation Carriers.
Auteur: Premi E, Costa T, Gazzina S, Benussi A, Cauda F, Gasparotti R, Archetti S, Alberici A, van Swieten JC, Sanchez-Valle R, Moreno F, Santana I, Laforce R, Ducharme S, Graff C, Galimberti D, Masellis M, Tartaglia C, Rowe JB, Finger E, Tagliavini F, de Mendonça A, Vandenberghe R, Gerhard A, Butler CR, Danek A, Synofzik M, Levin J, Otto M, Ghidoni R, Frisoni G, Sorbi S, Peakman G, Todd E, Bocchetta M, Rohrer JD, Borroni B; GENFI Consortium Members.
Magazine: Journal of Alzheimer's disease
Titel: Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics
Auteur: Emma L. van der Ende1 *, Lieke H. Meeter1 *, Christoph Stingl2 , Jeroen G. J. van Rooij1,3, Marcel P. Stoop2 , Diana A. T. Nijholt2 , Raquel Sanchez-Valle4 , Caroline Graff5,6, Linn Oijerstedt € 5,6, Murray Grossman7 , Corey McMillan7 , Yolande A. L. Pijnenburg8 , Robert Laforce Jr9 , Giuliano Binetti10,11, Luisa Benussi10, Roberta Ghidoni10, Theo M. Luider2 , Harro Seelaar1 & John C. van Swieten1
Magazine: Annals of Clinical and Translational Neurology
Titel: Differences in Discriminability and Response Bias on Rey Auditory Verbal Learning Test Delayed Recognition in Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease
Auteur: E. van den Berg1 , J.M. Poos1, L.C. Jiskoot1,2, L.M. Heijnen1, S. Franzen1 , R.M.E. Steketee3, R. Meijboom3,4,5, F.J. de Jong1, H. Seelaar1, J.C. van Swieten1 and J.M. Papma1
Magazine: Journal of the International Neuropsychological Society
Titel: CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
Auteur: van der Ende EL, Morenas-Rodriguez E, McMillan C, Grossman M, Irwin D, Sanchez-Valle R, Graff C, Vandenberghe R, Pijnenburg YAL, Laforce R, Ber IL, Lleo A, Haass C, Suarez-Calvet M, van Swieten JC, Seelaar H
Magazine: Neurobiology of Aging
Titel: Mindfulness-based stress reduction in presymptomatic genetic frontotemporal dementia.
Auteur: Poos, J.M., van den Berg, E., Papma, J.M., van der Tholen, F.C., Seelaar, H., Donker Kaat, L., Kievit, J.A., Tibben, A., van Swieten, J.C., Jiskoot, L.C.
Magazine: Frontiers in Psychiatry
Titel: Longitudinal cognitive changes in genetic frontotemporal dementia within the GENFI cohort
Auteur: Poos, J.M., Macdougall, A., van den Berg, E., Jiskoot, L.C., Papma, J.M., van der Ende, E., Seelaar, H., Russell, L.L., Peakman, G., Convery R.S, Pijnenburg, Y.A.L, Moreno, F., Sanchez-Valle, R., Borroni, B., Laforce, R., Doré, M.C., Masellis, M., Tartaglia, C., Graff, C., Galimberti, D, Rowe, J.B., Finger, E., Synofzik, M., Vandenberghe, R., de Mendonça, A., Tiraboschi, P., Santana, I., Ducharme, S., Butler, C., Gerhard, A., Levin, J., Danek, A., Otto, M., Le Ber, I., Pasquier, F., van Swiete
Magazine: Neurology
Titel: Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study
Auteur: Author links open overlay panelEmma Lvan der EndeMDaLieke HMeeterMDaJackie MPoosMScaJessica LPanmanMScabLize CJiskootPhDacElise G PDopperMDaJanne MPapmaPhDaFrank Jande JongMDaInge M WVerberkMScdProfCharlotteTeunissenPhDdProfDimitrisRizopoulosPhDeCarolinHellerMSccRhian SConveryMSccKatrina MMooreBSccMartinaBocchettaPhDcMollieNeasonMSccDavid MCashPhDcBarbaraBorroniMDfDanielaGalimbertiPhDghRaquelSanchez-ValleMDiRobertLaforceJrMDjFerminMorenoMDkProfMatthisSynofzikMDlmProfCarolineGraffMDnoMarioMaselli
Magazine: The Lancet Neurology
Titel: Longitudinal multimodal MRI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia
Auteur: Lize C Jiskoot, Jessica L Panman, Lieke H Meeter, Elise G P Dopper, Laura Donker Kaat, Sanne Franzen, Emma L van der Ende, Rick van Minkelen, Serge A R B Rombouts, Janne M Papma, John C van Swieten
Magazine: Brain
Titel: Poly(GP), neurofilament and grey matter deficits in C9orf72 expansion carriers
Auteur: Lieke H.H. Meeter1,a, Tania F. Gendron2,a, Ana C. Sias3 , Lize C. Jiskoot1,4,5, Silvia P. Russo3 , Laura Donker Kaat1,6, Janne M. Papma1 , Jessica L. Panman1,5, Emma L. van der Ende1 , Elise G. Dopper1 , Sanne Franzen1 , Caroline Graff7,8, Adam L. Boxer3 , Howard J. Rosen3 , Raquel Sanchez-Valle9 , Daniela Galimberti10, Yolande A. L. Pijnenburg11, Luisa Benussi12, Roberta Ghidoni12, Barbara Borroni13, Robert Laforce Jr14, Marta del Campo15 , Charlotte E. Teunissen15 , Rick van Minkelen16, Julio
Magazine: Annals of Clinical and Translational Neurology
Titel: Practice effects in genetic frontotemporal dementia and at-risk individuals: a GENFI study
Auteur: Öijerstedt L, Andersson C, Jelic V, van Swieten JC, Jiskoot LC, Seelaar H, Borroni B, Sanchez-Valle R, Moreno F, Laforce R Jr, Synofzik M, Galimberti D, Rowe JB, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, de Mendonca A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Frisoni G, Ghidoni R, Sorbi S, Rohrer JD, Graff C; Genetic Frontotemporal Dementia Initiative (GENFI).
Magazine: Journal of Neurology, Neurosurgery and Psychiatry
Titel: Gray and white matter changes in presymptomatic genetic frontotemporal dementia: a longitudinal MRI study
Auteur: Author links open overlay panelJessica L.PanmanabLize C.JiskootabMark J.R.J.BoutsbcLieke H.H.MeeteraEmma L.van der EndeabJackie M.PoosabRogier A.FeisbcdAnneke J.A.KieviteRickvan MinkeleneElise G.P.DopperabfSerge A.R.B.RomboutsbcdJohn C.van SwietenagJanne M.Papmaa
Magazine: Neurobiology of Aging
Titel: A modified Camel and Cactus Test detects presymptomatic semantic impairment in genetic frontotemporal dementia within the GENFI cohort
Auteur: Katrina Moore , Rhian Convery , Martina Bocchetta , Mollie Neason , David M. Cash , Caroline Greaves , Lucy L. Russell , Mica T. M. Clarke , Georgia Peakman , John van Swieten , Lize Jiskoot , Fermin Moreno , Myriam Barandiaran , Raquel Sanchez-Valle , Barbara Borroni , Robert Laforce Jr , Marie-Claire Doré , Mario Masellis , Maria Carmela Tartaglia , Caroline Graff , Daniela Galimberti , James B. Rowe , Elizabeth Finger , Matthis Synofzik , Hans-Otto Karnath , Rik Vandenberghe , Alexandre de M
Magazine: Applied Neuropsychology: Adult
Titel: Brain volumetric deficits in MAPT mutation carriers: a multisite study
Auteur: Stephanie A. Chu1 , Taru M. Flagan1, Adam M. Staffaroni1, Lize C. Jiskoot2,3, Jersey Deng1, Salvatore Spina1, Liwen Zhang1, Virginia E. Sturm1, Jennifer S. Yokoyama1, William W. Seeley1, Janne M. Papma2, Dan H. Geschwind4, Howard J. Rosen1, Bradley F. Boeve5, Adam L. Boxer1, Hilary W. Heuer1, Leah K. Forsberg5, Danielle E. Brushaber5, Murray Grossman6, Giovanni Coppola4, Bradford C. Dickerson7, Yvette M. Bordelon4, Kelley Faber8, Howard H. Feldman9, Julie A. Fields5, Jamie C. Fong1, Tatiana Foro
Magazine: Annals of Clinical and Translational Neurology
Titel: Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study
Auteur: Author links open overlay panelKatrina MMooreBScaJenniferNicholasPhDcProfMurrayGrossmanPhDdCorey TMcMillanPhDdDavid JIrwinPhDdLaurenMassimoPhDdProfVivianna MVan DeerlinPhDdProfJason DWarrenPhDaProfNick CFoxMDaProfMartin NRossorMDaProfSimonMeadPhDbMartinaBocchettaPhDaProfBradley FBoeveMDeProfDavid SKnopmanMDeProfNeill RGraff-RadfordPhDfLeah KForsbergPhDeProfRosaRademakersPhDgProfZbigniew KWszolekMDfProfJohn Cvan SwietenPhDhLize CJiskootPhDhLieke HMeeterPhDhElise GPDopperPhDhJanne MPapmaPhDhProfJu
Magazine: The Lancet Neurology
Titel: Comparison of clinical rating scales in genetic frontotemporal dementia within the GENFI cohort
Auteur: Peakman G, Russell LL, Convery RS, Nicholas JM, Van Swieten JC, Jiskoot LC, Moreno F, Sanchez-Valle R, Laforce R, Graff C, Masellis M, Tartaglia MC, Rowe JB, Borroni B, Finger E, Synofzik M, Galimberti D, Vandenberghe R, de Mendonça A, Butler CR, Gerhard A, Ducharme S, Le Ber I, Tagliavini F, Santana I, Pasquier F, Levin J, Danek A, Otto M, Sorbi S, Rohrer JD; Genetic FTD Initiative (GENFI).
Magazine: Journal of Neurology, Neurosurgery & Psychiatry
Titel: Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study
Auteur: Poos JM, Russell LL, Peakman G, Bocchetta M, Greaves CV, Jiskoot LC, van der Ende EL, Seelaar H, Papma JM, van den Berg E, Pijnenburg YAL, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Tartaglia C, Finger E, Vandenberghe R, de Medonça A, Tagliavini F, Butler CR, Santana I, Ber IL, Gerhard A, Ducharme S, Levin J, Danek A, Otto M, Sorbi S, Pasquier F, van Swieten JC, Rohrer JD; Genetic FTD Initiative, GENFI.
Magazine: Alzheimer's & Dementia
Titel: MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementia
Auteur: Manera AL, Dadar M, Van Swieten JC, Borroni B, Sanchez-Valle R, Moreno F, Laforce R Jr, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, de Mendonca A, Tagliavini F, Santana I, Butler CR, Gerhard A, Danek A, Levin J, Otto M, Frisoni G, Ghidoni R, Sorbi S, Rohrer JD, Ducharme S, Collins DL; FTLDNI investigators; GENFI Consortium
Magazine: Journal of Neurology, Neurosurgery and Psychiatry
Titel: Emotion recognition of morphed facial expressions in presymptomatic and symptomatic frontotemporal dementia, and Alzheimer’s dementia
Auteur: Lize C. Jiskoot1,3 · Jackie M. Poos1,2 · Manon E. Vollebergh1 · Sanne Franzen1 · Judy van Hemmen1 · Janne M. Papma1 · John C. van Swieten1 · Roy P. C. Kessels4,5 · Esther van den Berg1
Magazine: Journal of Neurology
Titel: Conceptual framework for the definition of preclinical and prodromal frontotemporal dementia
Auteur: Benussi A, Alberici A, Samra K, Russell LL, Greaves CV, Bocchetta M, Ducharme S, Finger E, Fumagalli G, Galimberti D, Jiskoot LC, Le Ber I, Masellis M, Nacmias B, Rowe JB, Sanchez-Valle R, Seelaar H, Synofzik M; GENFI Consortium, Rohrer JD,
Magazine: Alzheimer's & Dementia
Titel: Stratifying the Presymptomatic Phase of Genetic Frontotemporal Dementia by Serum NfL and pNfH: A Longitudinal Multicentre Study
Auteur: Wilke C, Reich S, van Swieten JC, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Galimberti D, Rowe JB, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Frisoni G, Ghidoni R, Sorbi S, Bocchetta M, Todd E, Kuhle J, Barro C; Genetic Frontotemporal dementia Initiative (GENFI), Rohrer JD, Synofzik M.
Magazine: Annals of Neurology
Titel: Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia
Auteur: Lize C. Jiskoot, Jessica L. Panman, Lauren van Asseldonk, Sanne Franzen, Lieke H. H. Meeter, Laura Donker Kaat, Emma L. van der Ende, Elise G. P. Dopper, Reinier Timman, Rick van Minkelen, John C. van Swieten, Esther van den Berg & Janne M. Papma
Magazine: Journal of Neurology
Titel: Differential early subcortical involvement in genetic FTD within the GENFI cohort
Auteur: Bocchetta M, Todd EG, Peakman G, Cash DM, Convery RS, Russell LL, Thomas DL, Eugenio Iglesias J, van Swieten JC, Jiskoot LC, Seelaar H, Borroni B, Galimberti D, Sanchez-Valle R, Laforce R, Moreno F, Synofzik M, Graff C, Masellis M, Carmela Tartaglia M, Rowe JB, Vandenberghe R, Finger E, Tagliavini F, de Mendonça A, Santana I, Butler CR, Ducharme S, Gerhard A, Danek A, Levin J, Otto M, Sorbi S, Le Ber I, Pasquier F, Rohrer JD; Genetic Frontotemporal dementia Initiative (GENFI).
Magazine: Neuroimage Clinical
Titel: Dissemination in time and space in presymptomatic granulin mutation carriers: a GENFI spatial chronnectome study
Auteur: Premi E, Giunta M, Iraji A, Rachakonda S, Calhoun VD, Gazzina S, Benussi A, Gasparotti R, Archetti S, Bocchetta M, Cash D, Todd E, Peakman G, Convery R, van Swieten JC, Jiskoot L, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Tartaglia C, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Butler CR, Santana I, Gerhard A, Le Ber I, Pasquier F, Ducharme S, Levin J, Danek A, Sorbi S, Otto M, Rohrer JD, Borroni B; Genetic Frontotemporal dementia I
Magazine: Neurobiology of Aging

Kenmerken

Projectnummer:
733050813
Looptijd: 100%
Looptijd: 100 %
2017
2022
Onderdeel van programma:
Gerelateerde subsidieronde:
Projectleider en penvoerder:
Prof. dr. J.C. van Swieten
Verantwoordelijke organisatie:
Erasmus MC