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NutriPROGRAM: Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways

Voeding tijdens de zwangerschap en in de vroege kindertijd kan een effect hebben op de latere gezondheid. Hoe voeding precies zo’n effect kan hebben, is niet goed bekend. Het zou kunnen, dat voeding leidt tot veranderingen in DNA methylatie. Dat zijn veranderingen die niet de structuur van het DNA veranderen, maar wel de activiteit van genen kunnen beïnvloeden. In het NutriPROGRAM project onderzoeken wij de relatie van voeding van moeder en kind met DNA methylatie en gezondheid in het latere leven. De nadruk ligt daarbij op metabole gezondheid, bijvoorbeeld overgewicht en suikerziekte. NutriPROGRAM gebruikt daarvoor gegevens uit bestaande studies bij zwangeren, kinderen en volwassenen. In NutriPROGRAM werken onderzoekers uit Nederland, Engeland, Duitsland, Spanje en Canada samen. Uiteindelijk zal deze internationale samenwerking leiden tot meer kennis over voeding, DNA methylatie en gezondheid gedurende het hele leven.

Producten

Titel: Genomic and phenomic insights from an atlas of genetic effects on DNA methylation
Auteur: Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, Bretherick AD, Richardson TG, Klughammer J, Iotchkova V, Sharp G, Al Khleifat A, Shatunov A, Iacoangeli A, McArdle WL, Ho KM, Kumar A, Söderhäll C, Soriano-Tárraga C, Giralt-Steinhauer E, Kazmi N, Mason D, McRae AF, Corcoran DL, Sugden K, Kasela S, Cardona A, Day FR, Cugliari G, Viberti C, Guarrera S, Lerro M, Gupta R, Bollepalli S, Mandaviya P, Zeng Y, Clarke TK, Walker
Magazine: Nature Genetics
Titel: Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Auteur: Merid SK, Novoloaca A, Sharp GC, Küpers LK, Kho AT, Roy R, Gao L, Annesi-Maesano I, Jain P, Plusquin M, Kogevinas M, Allard C, Vehmeijer FO, Kazmi N, Salas LA, Rezwan FI, Zhang H, Sebert S, Czamara D, Rifas-Shiman SL, Melton PE, Lawlor DA, Pershagen G, Breton CV, Huen K, Baiz N, Gagliardi L, Nawrot TS, Corpeleijn E, Perron P, Duijts L, Nohr EA, Bustamante M, Ewart SL, Karmaus W, Zhao S, Page CM, Herceg Z, Jarvelin MR, Lahti J, Baccarelli AA, Anderson D, Kachroo P, Relton CL, Bergström A, Esken
Magazine: Genome medicine
Titel: Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
Auteur: Sharp GC, Alfano R, Ghantous A, Urquiza J, Rifas-Shiman SL, Page CM, Jin J, Fernández-Barrés S, Santorelli G, Tindula G, Yousefi P, Küpers L, Ruiz-Arenas C, Jaddoe VWV, DeMeo D, Fossati S, Wright J, Huen K, Popovic M, Nohr EA, Davey Smith G, Lepeule J, Baccarelli A, Magnus MC, Nystad W, Casas M, Oken E, Håberg SE, Vafeiadi M, Roumeliotaki T, Vrijheid M, Munthe-Kaas MC, Eskenazi B, Ronfani L, Holland N, Chatzi L, Meltzer HM, Herceg Z, Plusquin M, Bustamante M, Hivert MF, Lawlor DA, Sørensen
Magazine: International Journal of Epidemiology
Titel: Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis
Auteur: Neumann, Alexander, Walton, Esther, Alemany, Silvia, Cecil, Charlotte, González, Juan Ramon, Jima, Dereje D., Lahti, Jari, Tuominen, Samuli T., Barker, Edward D., Binder, Elisabeth, Caramaschi, Doretta, Carracedo, Ángel, Czamara, Darina, Evandt, Jorunn, Felix, Janine F., Fuemmeler, Bernard F., Gutzkow, Kristine B., Hoyo, Cathrine, Julvez, Jordi, Kajantie, Eero, Laivuori, Hannele, Maguire, Rachel, Maitre, Léa, Murphy, Susan K., Murcia, Mario, Villa, Pia M., Sharp, Gemma, Sunyer, Jordi, Raikkö
Magazine: BioRxiv
Titel: Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age
Auteur: Monasso GS, Felix JF, Heil SG, de Rijke YB, Gaillard R, Jaddoe VWV
Magazine: Clinical Nutrition
Titel: Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data
Auteur: Gervin, Kristina, Salas, Lucas A., Bakulski, Kelly M., van Zelm, Menno C., Koestler, Devin C., Wiencke, John K., Duijts, Liesbeth, Moll, Henriëtte A., Kelsey, Karl T., Kobor, Michael S., Lyle, Robert, Christensen, Brock C., Felix, Janine F., Jones, Meaghan J.
Magazine: Clinical Epigenetics
Titel: Associations of maternal early-pregnancy blood glucose and insulin concentrations with DNA methylation in newborns
Auteur: Geurtsen ML, Jaddoe VWV, Gaillard R, Felix JF
Magazine: Clinical Epigenetics
Titel: DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
Auteur: van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, Walker RM, Morris SW, Lahti J, Küpers LK, Escaramis G, Alemany S, Jan Bonder M, Meijer M, Ip HF, Jansen R, Baselmans BML, Parmar P, Lowry E, Streit F, Sirignano L, Send TS, Frank J, Jylhävä J, Wang Y, Mishra PP, Colins OF, Corcoran DL, Poulton R, Mill J, Hannon E, Arseneault L, Korhonen T, Vuoksimaa E, Felix JF, Bakermans-Kranenburg MJ, Campbell A, Czamara D, Binder E, Cor
Magazine: Molecular Psychiatry
Titel: Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study
Auteur: Sol CM, Gaylord A, Santos S, Jaddoe VWV, Felix JF, Trasande L
Magazine: Clinical Epigenetics
Titel: Maternal adherence to the Mediterranean diet during pregnancy: a review of commonly used a priori indexes
Auteur: Eckl M, Brouwer-Brolsma E, Küpers L
Magazine: Nutrients
Titel: Associations of maternal and infant metabolite profiles with foetal growth and the odds of adverse birth outcomes
Auteur: Voerman E, Jaddoe VWV, Shokry E, Ruijter GJG, Felix JF, Koletzko B, Gaillard R
Magazine: Pediatric Obesity
Titel: Associations Between Intake of Sugar-Containing Beverages in Infancy With Liver Fat Accumulation at School Age
Auteur: Geurtsen ML, Santos S, Gaillard R, Felix JF, Jaddoe VWV
Magazine: Hepatology
Titel: Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study
Auteur: Koopman-Verhoeff ME, Mulder RH, Saletin JM, Reiss I, van der Horst GTJ, Felix JF, Carskadon MA, Tiemeier H, Cecil CAM
Magazine: Journal of Child Psychology and Psychiatry
Titel: Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation
Auteur: Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, Gao L, Bakulski KM, Novoloaca A, Allard C, Pappa I, Llambrich M, Vives M, Jima DD, Kvist T, Baccarelli A, White C, Rezwan FI, Sharp GC, Tindula G, Bergström A, Grote V, Dou JF, Isaevska E, Magnus MC, Corpeleijn E, Perron P, Jaddoe VWV, Nohr EA, Maitre L, Foraster M, Hoyo C, Håberg SE, Lahti J, DeMeo DL, Zhang H, Karmaus W, Kull I, Koletzko B, Feinberg JI, Gagliardi L, Bouchard L, Ramlau
Magazine: Reviews in Mutation Research
Titel: Fetal and childhood exposure to parental tobacco smoking and arterial health at age 10 years
Auteur: Monasso GS, Felix JF, Gaillard R, Jaddoe VWV
Magazine: American Journal of Hypertension
Titel: Maternal Body Mass Index, Early-Pregnancy Metabolite Profile, and Birthweight
Auteur: Wahab RJ, Jaddoe VWV, Voerman E, Ruijter GJG, Felix JF, Marchioro L, Uhl O, Shokry E, Koletzko B, Gaillard R
Magazine: Journal of Clinical Endocrinology & Metabolism
Titel: Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium
Auteur: Küpers LK, Fernández-Barrés S, Nounu A, Friedman C, Fore R, Mancano G, Dabelea D, Rifas-Shiman SL, Mulder RH, Oken E, Johnson L, Bustamante M, Jaddoe VWV, Hivert MF, Starling AP, de Vries JHM, Sharp GC, Vrijheid M, Felix JF
Magazine: Epigenetics
Titel: Epigenome-wide contributions to individual differences in childhood phenotypes:a GREML approach
Auteur: Neumann A, Pingault JB, Felix JF, Jaddoe VWV, Tiemeier H, Cecil C, Walton E
Magazine: Clinical Epigenetics
Titel: Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium
Auteur: Ronkainen J, Heiskala A, Vehmeijer FOL, Lowry E, Caramaschi D, Estrada Gutierrez G, Heiss JA, Hummel N, Keikkala E, Kvist T, Kupsco A, Melton PE, Pesce G, Soomro MH, Vives-Usano M, Baiz N, Binder E, Czamara D, Guxens M, Mustaniemi S, London SJ, Rauschert S, Vääräsmäki M, Vrijheid M, Ziegler AG, Annesi-Maesano I, Bustamante M, Huang RC, Hummel S, Just AC, Kajantie E, Lahti J, Lawlor D, Räikkönen K, Järvelin MR, Felix JF, Sebert S
Magazine: Epigenetics
Titel: Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth
Auteur: Monasso GS, Voortman T, Felix JF
Magazine: Epigenetics
Titel: Newborn and childhood differential DNA methylation and liver fat in school-age children
Auteur: Geurtsen, Madelon L., Jaddoe, Vincent W. V., Salas, Lucas A., Santos, Susana, Felix, Janine F.
Magazine: Clinical Epigenetics
Titel: Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis
Auteur: Yeung EH, Guan W, Zeng X, Salas LA, Mumford SL, de Prado Bert P, van Meel ER, Malmberg A, Sunyer J, Duijts L, Felix JF, Czamara D, Hämäläinen E, Binder EB, Räikkönen K, Lahti J, London SJ, Silver RM, Schisterman EF
Magazine: Clinical Epigenetics
Titel: Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study
Auteur: Monasso GS, Jaddoe VWV, Küpers LK, Felix JF
Magazine: Clinical Epigenetics
Titel: Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children
Auteur: Dall' Aglio L, Rijlaarsdam J, Mulder RH, Neumann A, Felix JF, Kok R, Bakermans-Kranenburg MJ, van Ijzendoorn MH, Tiemeier H, Cecil CAM
Magazine: Psychological Medicine
Titel: Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills
Auteur: Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hivert MF, Oken E, Sunyer J, Cecil CAM, Sharp G
Magazine: Molecular Psychiatry
Titel: Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation
Auteur: Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ, Alemany S, McBride NS, Yousefi P, Heiss JA, McRae N, Page CM, Jin J, Pesce G, Caramaschi D, Rifas-Shiman SL, Koen N, Adams CD, Magnus MC, Baïz N, Ratanatharathorn A, Czamara D, Håberg SE, Colicino E, Baccarelli AA, Cardenas A, DeMeo DL, Lawlor DA, Relton CL, Felix JF, van IJzendoorn MH, Bakermans-Kranenburg MJ, Kajantie E, Räikkönen K, Sunyer J, Sharp GC, Houtepen LC, Nohr EA, Sørensen TIA, Téllez-Rojo MM, Wrig
Magazine: Molecular Psychiatry
Titel: Epigenome-wide change and variation in DNA methylation in childhood: Trajectories from birth to late adolescence
Auteur: Mulder RH, Neumann A, Cecil CAM, Walton E, Houtepen LC, Simpkin AJ, Rijlaarsdam J, Heijmans BT, Gaunt TR, Felix JF, Jaddoe VWV, Bakermans-Kranenburg MJ, Tiemeier H, Relton CL, van IJzendoorn MH, Suderman M
Magazine: Human Molecular Genetics
Titel: Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation
Auteur: Küpers LK, Fernández-Barrés S, Mancano G, Johnson L, Ott R, Vioque J, Colombo M, Landgraf K, Tobi EW, Körner A, Gaillard R, de Vries JHM, Jaddoe VWV, Vrijheid M, Sharp GC, Felix JF
Magazine: Diabetes Care
Titel: Longitudinal associations of DNA methylation and sleep in children: a meta-analysis
Auteur: Sammallahti S, Koopman-Verhoeff ME, Binter AC, Mulder RH, Cabré-Riera A, Kvist T, Malmberg ALK, Pesce G, Plancoulaine S, Heiss JA, Rifas-Shiman SL, Röder SW, Starling AP, Wilson R, Guerlich K, Haftorn KL, Page CM, Luik AI, Tiemeier H, Felix JF, Raikkonen K, Lahti J, Relton CL, Sharp GC, Waldenberger M, Grote V, Heude B, Annesi-Maesano I, Hivert MF, Zenclussen AC, Herberth G, Dabelea D, Grazuleviciene R, Vafeiadi M, Håberg SE, London SJ, Guxens M, Richmond RC, Cecil CAM
Magazine: Clinical Epigenetics
Titel: A population-based resource for intergenerational metabolomics analyses in pregnant women and their children: the Generation R Study
Auteur: Voerman E, Jaddoe VWV, Uhl O, Shokry E, Horak J, Felix JF, Koletzko B, Gaillard R
Magazine: Metabolomics
Titel: Associations of Early Pregnancy and Neonatal Circulating Folate, Vitamin B-12, and Homocysteine Concentrations with Cardiometabolic Risk Factors in Children at 10 y of Age
Auteur: Monasso GS, Santos S, Geurtsen ML, Heil SG, Felix JF, Jaddoe VWV
Magazine: Journal of Nutrition
Titel: Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration
Auteur: Marques I, Santos S, Monasso GS, Fossati S, Vrijheid M, Nieuwenhuijsen M, Jaddoe VWV, Felix JF
Magazine: Epigenetics
Titel: Infant weight growth patterns, childhood BMI, and arterial health at age 10 years
Auteur: Monasso GS, Silva CCV, Santos S, Goncalvez R, Gaillard R, Felix JF, Jaddoe VWV
Magazine: Obesity
Titel: Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
Auteur: Luo M, Meehan AJ, Walton E, Röder S, Herberth G, Zenclussen AC, Cosín-Tomás M, Sunyer J, Mulder RH, Cortes Hidalgo AP, Bakermans-Kranenburg MJ, Felix JF, Relton C, Suderman M, Pappa I, Kok R, Tiemeier H, van IJzendoorn MH, Barker ED, Cecil CAM
Magazine: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Titel: Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies
Auteur: Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, Binder E, Caiazzo R, Chan JKY, Gaillard R, Gluckman PD, Keikkala E, Karnani N, Mustaniemi S, Nawrot TS, Pattou F, Plusquin M, Raverdy V, Tan KH, Tzala E, Raikkonen K, Winkler C, Ziegler AG, Annesi-Maesano I, Bouchard L, Chong YS, Dabelea D, Felix JF, Heude B, Jaddoe VWV, Lahti J, Reimann B, Vääräsmäki M, Bonnefond A, Froguel P
Magazine: Diabetes Care
Titel: DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
Auteur: Vehmeijer FOL, Küpers LK, Sharp GC, Salas LA, Lent S, Jima DD, Tindula G, Reese S, Qi C, Gruzieva O, Page C, Rezwan FI, Melton PE, Nohr E, Escaramís G, Rzehak P, Heiskala A, Gong T, Tuominen ST, Gao L, Ross JP, Starling AP, Holloway JW, Yousefi P, Aasvang GM, Beilin LJ, Bergström A, Binder E, Chatzi L, Corpeleijn E, Czamara D, Eskenazi B, Ewart S, Ferre N, Grote V, Gruszfeld D, Håberg SE, Hoyo C, Huen K, Karlsson R, Kull I, Langhendries JP, Lepeule J, Magnus MC, Maguire RL, Molloy PL, Monner
Magazine: Genome medicine
Titel: Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis
Auteur: Taeubert MJ, de Prado-Bert P, Geurtsen ML, Mancano G, Vermeulen MJ, Reiss IKM, Caramaschi D, Sunyer J, Sharp GC, Julvez J, Muckenthaler MU, Felix JF
Magazine: Clinical Epigenetics
Titel: The EU Child Cohort Network's core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables
Auteur: Pinot de Moira A, Haakma S, Strandberg-Larsen K, van Enckevort E, Kooijman M, Cadman T, Cardol M, Corpeleijn E, Crozier S, Duijts L, Elhakeem A, Eriksson JG, Felix JF, Fernández-Barrés S, Foong RE, Forhan A, Grote V, Guerlich K, Heude B, Huang RC, Järvelin MR, Jørgensen AC, Mikkola TM, Nader JLT, Pedersen M, Popovic M, Rautio N, Richiardi L, Ronkainen J, Roumeliotaki T, Salika T, Sebert S, Vinther JL, Voerman E, Vrijheid M, Wright J, Yang TC, Zariouh F, Charles MA, Inskip H, Jaddoe VWV, Swer
Magazine: European Journal of Epidemiology
Titel: Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Auteur: Küpers, Leanne K., Monnereau, Claire, Sharp, Gemma C., Yousefi, Paul, Salas, Lucas A., Ghantous, Akram, Page, Christian M., Reese, Sarah E., Wilcox, Allen J., Czamara, Darina, Starling, Anne P., Novoloaca, Alexei, Lent, Samantha, Roy, Ritu, Hoyo, Cathrine, Breton, Carrie V., Allard, Catherine, Just, Allan C., Bakulski, Kelly M., Holloway, John W., Everson, Todd M., Xu, Cheng-Jian, Huang, Rae-Chi, van der Plaat, Diana A., Wielscher, Matthias, Merid, Simon Kebede, Ullemar, Vilhelmina, Rezwan, Fai
Magazine: Nature Communications
Titel: Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
Auteur: Sikdar, Sinjini, Joehanes, Roby, Joubert, Bonnie R, Xu, Cheng-Jian, Vives-Usano, Marta, Rezwan, Faisal I, Felix, Janine F, Ward, James M, Guan, Weihua, Richmond, Rebecca C, Brody, Jennifer A, Küpers, Leanne K, Baïz, Nour, Håberg, Siri E, Smith, Jennifer A, Reese, Sarah E, Aslibekyan, Stella, Hoyo, Cathrine, Dhingra, Radhika, Markunas, Christina A, Xu, Tao, Reynolds, Lindsay M, Just, Allan C, Mandaviya, Pooja R, Ghantous, Akram, Bennett, Brian D, Wang, Tianyuan, Consortium, The BIOS, Bakulski,
Magazine: Epigenomics
Titel: Maternal early-pregnancy glucose concentrations and liver fat among school age children
Auteur: Geurtsen ML, Wahab RJ, Felix JF, Gaillard R, Jaddoe VWV
Magazine: Hepatology
Titel: Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study
Auteur: Monasso GS, Küpers LK, Jaddoe VWV, Heil SG, Felix JF
Magazine: Clinical Epigenetics
Titel: Timing- and Dose-Specific Associations of Prenatal Smoke Exposure With Newborn DNA Methylation
Auteur: Monasso GS, Jaddoe VWV, de Jongste JC, Duijts L, Felix JF
Magazine: Nicotine and Tobacco Research
Titel: Epigenome-wide association study of seizures in childhood and adolescence
Auteur: Caramaschi, Doretta, Hatcher, Charlie, Mulder, Rosa H., Felix, Janine F., Cecil, Charlotte A. M., Relton, Caroline L., Walton, Esther
Magazine: Clinical Epigenetics
Titel: Biosamples panel session
Auteur: Janine Felix
Titel: Maternal Factors and (Epi-)genetics
Auteur: Janine Felix
Titel: Pregnancy exposures and offspring DNA methylation
Auteur: Janine Felix
Titel: Introduction to the Analysis of Population Epigenomics & Transcriptomics
Auteur: Leanne Küpers, Janine Felix
Titel: DNA methylation
Auteur: Janine Felix

Onderwerpen

Kenmerken

Projectnummer:
529051022
Looptijd: 100%
Looptijd: 100 %
2019
2022
Onderdeel van programma:
Gerelateerde subsidieronde:
Projectleider en penvoerder:
dr. J. Felix
Verantwoordelijke organisatie:
Erasmus Medisch Centrum