PHENOSEP: Clinical phenotypes in sepsis: trajectories and association with the host response

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Titel: Precision medicine in critically ill patients
Auteur: Rombout Benjamin Ezra van Amstel
Link: https://dare.uva.nl/search?identifier=fea448ae-88eb-4642-9656-9187ce281c46
Titel: Immune response in severe infection
Auteur: Marleen A Slim
Link: https://dare.uva.nl/search?identifier=47a25864-9043-4221-8620-e3e3bf5147cb
Titel: Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study
Auteur: Marit J van Gils, Ayesha Lavell, Karlijn van der Straten, Brent Appelman, Ilja Bontjer, Meliawati Poniman Judith A Burger, Melissa Oomen, Joey H Bouhuijs, Lonneke A van Vught, Marleen A Slim, Michiel Schinkel, Elke Wynberg, Hugo D G van Willigen, Marloes Grobben, Khadija Tejjani, Jacqueline van Rijswijk, Jonne L Snitselaar, Tom G Caniels; Amsterdam UMC COVID-19 S3/HCW study group; Alexander P J Vlaar, Maria Prins, Menno D de Jong, Godelieve J de Bree, Jonne J Sikkens, Marije K Bomers, Rogier W
Magazine: Plos Medicine
Link: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003991
Titel: Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination
Auteur: Tom G Caniels, Ilja Bontjer, Karlijn van der Straten, Meliawati Poniman, Judith A Burger, Brent Appelman, A H Ayesha Lavell, Melissa Oomen, Gert-Jan Godeke, Coralie Valle, Ramona Mögling, Hugo D G van Willigen, Elke Wynberg, Michiel Schinkel, Lonneke A van Vught, Denise Guerra, Jonne L Snitselaar, Devidas N Chaturbhuj, Isabel Cuella Martin; Amsterdam UMC COVID-19 S3/HCW study group; John P Moore, Menno D de Jong, Chantal Reusken, Jonne J Sikkens, Marije K Bomers, Godelieve J de Bree
Magazine: Science Advances
Link: https://www.science.org/doi/10.1126/sciadv.abj5365?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Titel: COVID-19 Pathophysiology: An Opportunity to Start Appreciating Time-Dependent Variation
Auteur: Lonneke A. van Vught and Lieuwe D. J. Bos
Magazine: American Journal of Respiratory and Critical Care Medicine
Begin- en eindpagina: 483-485
Link: https://www.atsjournals.org/doi/10.1164/rccm.202112-2857ED?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Titel: Intracellular expression of granzymes A, B, K and M in blood lymphocyte subsets of critically ill patients with or without sepsis
Auteur: M Isabel García-Laorden, Arie J Hoogendijk, Maryse A Wiewel, Lonneke A van Vught, Marcus J Schultz, Niels Bovenschen, Alex F de Vos, Tom van der Poll
Magazine: Clinical and Experimental Immunology
Begin- en eindpagina: 222-231
Link: https://academic.oup.com/cei/article/205/2/222/6431063?login=true
Titel: Non-conventional immunomodulation in the management of sepsis
Auteur: M.A. Slim, O. Turgman, L.A. van Vught, T. van der Poll, W.J. Wiersinga
Magazine: European Journal of Internal Medicine
Begin- en eindpagina: 9-16
Link: https://www.sciencedirect.com/science/article/pii/S0953620523003874?via%3Dihub
Titel: Host Response Protein Biomarkers Indicative of Persistent Acute Kidney Injury in Critically Ill COVID-19 Patients
Auteur: Steenvoorden, Thei S; de Kruijf, Koen C; Appelman, Brent; Moggre, Bas; Bos, Lieuwe D. J; Vlaar, Alexander P. J. Douma, Reneé A. ; Uhel, Fabrice ; Kers, Jesper MD, ; Oppelaar, Jetta J. ; van Vught, Lonneke A. ; Beudel, Martijn; Elbers, Paul W. G.; Wiersinga, W. Joost; van der Poll, Tom, Vogt, Liffert; Peters-Sengers, Hessel on behalf of the Amsterdam UMC COVID-19 Biobank Study Group and the CovidPredict Study Group
Magazine: Critical care explorations
Link: https://journals.lww.com/ccejournal/fulltext/2025/03000/host_response_protein_biomarkers_indicative_of.8.aspx
Titel: The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients
Auteur: M. A. Slim, E. H. T. Lim, L. A. van Vught, A. M. Tuip-de Boer, E. Rademaker, J. L. G. Haitsma Mulier, J. J. Engel, The Amsterdam UMC COVID-19 Biobank Study Group, The Radboudumc Center for Infectious Diseases COVID-19 Study Group, P. Pickkers, F. L. van de Veerdonk, A. P. J. Vlaar, L. P. G. Derde & N. P. Juffermans
Magazine: Scietific reports
Link: https://www.nature.com/articles/s41598-024-59385-w
Titel: A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients
Auteur: Niels van Mourik, Rombout B. E. van Amstel, Marleen A. Slim, Lonneke A. van Vught, Tom van der Poll, Joram Huckriede, Femke de Vries, Sjef J. de Kimpe, Raf Crabbé, Simone J. M. van Leeuwen, Peter F. Ekhart, Chris P. M. Reutelingsperger, Gerry A. F. Nicolaes, Alexander P. J. Vlaar & Marcella C. A. Müller
Magazine: Intensive Care Medicine Experimental
Link: https://link.springer.com/article/10.1186/s40635-025-00790-4
Titel: Heterogeneity of treatment effect of vilobelimab in COVID-19: a secondary analysis of a randomised controlled trial
Auteur: Rombout B. E. van Amstel, Marleen A. Slim, Endry H. T. Lim, Simon Rückinger, Christopher W. Seymour, Bruce P. Burnett, Lieuwe D. J. Bos, Lonneke A. van Vught, Niels C. Riedemann, Diederik van de Beek, Alexander P. J. Vlaar & the PANAMO Study Group
Magazine: Critical Care
Link: https://link.springer.com/article/10.1186/s13054-024-05004-z
Titel: Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis
Auteur: Lonneke A van Vught, Fabrice Uhel, Chao Ding, Cees van‘t Veer, Brendon P Scicluna, Hessel Peters-Sengers, Peter M C Klein Klouwenberg, Peter Nürnberg, Olaf L Cremer, Marcus J Schultz, Tom van der Poll; the MARS consortium
Magazine: J Thromb Haemost
Begin- en eindpagina: 1049-1063
Link: https://www.sciencedirect.com/science/article/pii/S1538783622007267?via%3Dihub
Titel: SARS-CoV-2 antibody prevalence and correlates of six ethnic groups living in Amsterdam, the Netherlands: a population-based cross-sectional study, June-October 2020
Auteur: Liza Coyer, Anders Boyd, Janke Schinkel, Charles Agyemang, Henrike Galenkamp, Anitra D M Koopman, Tjalling Leenstra, Eric P Moll van Charante, Bert-Jan H van den Born, Anja Lok, Arnoud Verhoeff, Aeilko H Zwinderman, Suzanne Jurriaans, Lonneke A van Vught, Karien Stronks , Maria Prins
Magazine: BMJ open
Link: https://bmjopen.bmj.com/content/12/1/e052752.long
Titel: COVID-19 Pathophysiology: An Opportunity to Start Appreciating Time-Dependent Variation
Auteur: Lonneke A van Vught, Lieuwe D J Bos
Magazine: American Journal of Respiratory and Critical Care Medicine
Link: https://www.atsjournals.org/doi/10.1164/rccm.202112-2857ED?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Titel: Sepsis Subclasses: A Framework for Development and Interpretation
Auteur: Kimberley M DeMerle, Derek C Angus, J Kenneth Baillie, Emily Brant, Carolyn S Calfee, Joseph Carcillo, Chung-Chou H Chang, Robert Dickson, Idris Evans, Anthony C Gordon, Jason Kennedy, Julian C Knight, Christopher J Lindsell, Vincent Liu, John C Marshall, Adrienne G Randolph, Brendon P Scicluna, Manu Shankar-Hari, Nathan I Shapiro, Timothy E Sweeney, Victor B Talisa, Benjamin Tang, B Taylor Thompson, Ephraim L Tsalik, Tom van der Poll, Lonneke A van Vught, Hector R Wong, Sachin Yende, Huiying Z
Magazine: Critical Care Medicine
Begin- en eindpagina: 748-759
Link: https://journals.lww.com/ccmjournal/fulltext/2021/05000/sepsis_subclasses__a_framework_for_development_and.4.aspx
Titel: A Transient Inflammatory Response Induced by Lipopolysaccharide Infusion Lowers Markers of Endogenous Cholesterol and Bile Acid Synthesis in Healthy Normocholesterolemic Young Men
Auteur: Sultan Mashnafi, Sabine Baumgartner, Ronald P Mensink, Desiree Perlee, Lonneke A van Vught, Dieter Lütjohann , Jogchum Plat
Magazine: Biomedicines
Link: https://www.mdpi.com/2227-9059/11/1/126
Titel: Clinical Subtype Trajectories in Sepsis Patients Admitted to the ICU: A Secondary Analysis of an Observational Study
Auteur: Slim, Marleen A. van Amstel, Rombout B. E. Müller, Marcella C.A. Cremer, Olaf L. Vlaar, Alexander P. J. van der Poll, Tom Wiersinga, W. Joost MD, Seymour, Christopher W. van Vught, Lonneke A. MARS Consortium
Magazine: Critical care explorations
Link: https://journals.lww.com/ccejournal/fulltext/2024/11000/clinical_subtype_trajectories_in_sepsis_patients.7.aspx
Titel: Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation
Auteur: Tom D Y Reijnders, Hessel Peters-Sengers, Lonneke A van Vught, Fabrice Uhel, Marc J M Bonten, Olaf L Cremer, Marcus J Schultz, Martijn M Stuiver, Tom van der Poll; MARS consortium
Magazine: Critical care
Begin- en eindpagina: 151-
Link: https://link.springer.com/article/10.1186/s13054-022-04016-x
Titel: Complement activation in COVID-19 and targeted therapeutic options: A scoping review
Auteur: Endry Hartono Taslim Lim, Rombout Benjamin Ezra van Amstel, Vieve Victoria de Boer, Lonneke Alette van Vught, Sanne de Bruin, Matthijs Christian Brouwer, Alexander Petrus Johannes Vlaar, Diederik van de Beek
Magazine: Blood review
Link: https://www.sciencedirect.com/science/article/pii/S0268960X22000698?via%3Dihub
Titel: Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the phase 2 PANAMO trial
Auteur: Endry H T Lim, Alexander P J Vlaar, Lieuwe D J Bos, Lonneke A van Vught, Anita M Tuip-de Boer, Romein W G Dujardin, Maria Habel, Zhongli Xu, Matthijs C Brouwer, Diederik van de Beek, Sanne de Bruin; Amsterdam UMC COVID-19 Biobank Investigators
Magazine: Respiratory research
Begin- en eindpagina: 375-
Link: https://link.springer.com/article/10.1186/s12931-022-02278-1
Titel: Personalised immunotherapy in sepsis: a scoping review protocol
Auteur: Marleen A Slim, Niels van Mourik, Joanna C Dionne, Simon J W Oczkowski, M G Netea, Peter Pickkers, Evangelos J Giamarellos-Bourboulis, Marcella C A Müller, Tom van der Poll, W Joost Wiersinga, Alexander P J Vlaar, Lonneke A van Vught
Magazine: BMJ open
Link: https://bmjopen.bmj.com/content/12/5/e060411.long
Titel: Real-world Evidence of the Effects of Novel Treatments for COVID-19 on Mortality: A Nationwide Comparative Cohort Study of Hospitalized Patients in the First, Second, Third, and Fourth Waves in the Netherlands
Auteur: Marleen A Slim , Brent Appelman , Hessel Peters-Sengers , Dave A Dongelmans , Nicolette F de Keizer , Rogier P Schade , Mark G J de Boer , Marcella C A Müller , Alexander P J Vlaar , W Joost Wiersinga , Lonneke A van Vught , NICE COVID-19 Research Consortium and the COVIDPredict study group
Magazine: Open Forum Infectious Diseases
Link: https://academic.oup.com/ofid/article/9/12/ofac632/6835935
Titel: Clinical sepsis phenotypes in critically ill COVID-19 patients
Auteur: Niklas Bruse, Emma J Kooistra, Aron Jansen, Rombout B E van Amstel, Nicolette F de Keizer, Jason N Kennedy, Christopher Seymour, Lonneke A van Vught, Peter Pickkers, Matthijs Kox
Magazine: Critical care
Begin- en eindpagina: 244-
Link: https://link.springer.com/article/10.1186/s13054-022-04118-6
Titel: Sepsis Subclasses: A Framework for Development and Interpretation
Auteur: Kimberley DeMerle, Derek Angus, Kenneth Baillie, Emily Brant, Carolyn Calfee, Joseph Carcillo, Chung-Chou Chang, Robert Dickson, Idris Evans, Anthony Gordon, Jason Kennedy, Julian Knight, Christopher Lindsell, Vincent Liu, John Marshall, Adrienne Randolph, Brendon Scicluna, Manu Shankar-Hari, Nathan Shapiro, Timothy Sweeney, Victor Talisa, Benjamin Tang, B Taylor Thompson, Ephraim Tsalik, Tom van der Poll, Lonneke A van Vught, Hector R Wong Sachin Yende, Huiying Zhao, Christopher W Seymour
Magazine: Critical Care Medicine
Link: https://journals.lww.com/ccmjournal/fulltext/2021/05000/sepsis_subclasses__a_framework_for_development_and.4.aspx
Titel: Association between age and the host response in critically ill patients with sepsis
Auteur: Erik H A Michels, Joe M Butler, Tom D Y Reijnders, Olaf L Cremer, Brendon P Scicluna, Fabrice Uhel, Hessel Peters-Sengers, Marcus J Schultz, Julian C Knight, Lonneke A van Vught, Tom van der Poll; MARS consortium
Magazine: Critical care
Begin- en eindpagina: 385-
Link: https://link.springer.com/article/10.1186/s13054-022-04266-9
Titel: The circulatory small non-coding RNA landscape in community-acquired pneumonia on intensive care unit admission
Auteur: Hina N Khan, Aldo Jongejan, Lonneke A van Vught, Janneke Horn, Marcus J Schultz, Aeilko H Zwinderman, Olaf L Cremer, Marc J Bonten, Tom van der Poll, Brendon P Scicluna
Magazine: Journal of cellular and moleculair medicine
Begin- en eindpagina: 7621-7630
Link: https://onlinelibrary.wiley.com/doi/10.1111/jcmm.16406
Titel: Integrating biology into clinical trial design
Auteur: Rombout B E van Amstel, Lonneke A van Vught, Lieuwe D J Bos
Magazine: Current opinion Critical Care
Link: https://journals.lww.com/co-criticalcare/fulltext/2023/02000/integrating_biology_into_clinical_trial_design.6.aspx
Titel: Clinical subtypes in critically ill patients with sepsis: validation and parsimonious classifier model development
Auteur: Rombout B. E. van Amstel, Emma Rademaker, Jason N. Kennedy, Lieuwe D. J. Bos, Hessel Peters-Sengers, Joe M. Butler, Niklas Bruse, Dave A. Dongelmans, Matthijs Kox, Alexander P. J. Vlaar, Tom van der Poll, Olaf L. Cremer, Christopher W. Seymour & Lonneke A. van Vught
Magazine: Critical Care
Link: https://link.springer.com/article/10.1186/s13054-025-05256-3
Titel: Subphenotypes in critical illness: a priori biological rationale is key
Auteur: Rombout B. E. van Amstel, Olaf L. Cremer, Lonneke A. van Vught, Lieuwe D. J. Bos on behalf of the MARS consortium
Magazine: Intensive Care Medicine
Begin- en eindpagina: 299-301
Link: https://link.springer.com/article/10.1007/s00134-023-07273-8
Titel: Inflammatory biomarkers at hospital discharge are associated with readmission and death in patients hospitalized for COVID-19
Auteur: Slim MA, Appelman B, Muller MCA, Brouwer MC, Vlaar APJ, Wiersinga WJ, van Vught LA
Magazine: Eur J Clin Microbiol Infect Dis
Begin- en eindpagina: 2677-2683
Link: https://link.springer.com/article/10.1007/s10096-021-04355-7
Titel: Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients
Auteur: Xanthe Brands, Fabrice Uhel, Lonneke A van Vught Maryse A Wiewel Arie J Hoogendijk, René Lutter, Marcus J Schultz, Brendon P Scicluna, Tom van der Poll
Magazine: Plos one
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271637
Titel: Real-world Evidence of the Effects of Novel Treatments for COVID-19 on Mortality: A Nationwide Comparative Cohort Study of Hospitalized Patients in the First, Second, Third, and Fourth Waves in the Netherlands
Auteur: Marleen A Slim, Brent Appelman, Hessel Peters-Sengers, Dave A Dongelmans, Nicolette F de Keizer, Rogier P Schade, Mark G J de Boer, Marcella C A Müller, Alexander P J Vlaar, W Joost Wiersinga, Lonneke A van Vught
Magazine: Open Forum Infectious Diseases
Link: https://academic.oup.com/ofid/article/9/12/ofac632/6835935?login=true
Titel: Inflammatory subphenotypes previously identified in ARDS are associated with mortality at intensive care unit discharge: a secondary analysis of a prospective observational study
Auteur: Marleen A Slim, Rombout B E van Amstel, Lieuwe D J Bos, Olaf L Cremer; MARS Consortium; W Joost Wiersinga, Tom van der Poll, Lonneke A van Vught
Magazine: Critical Care
Link: https://ccforum.biomedcentral.com/articles/10.1186/s13054-024-04929-9
Titel: Non-conventional immunomodulation in the management of sepsis
Auteur: M A Slim, Turgman, L A van Vught, T van der Poll, W J Wiersinga
Magazine: European Journal of Internal Medicine
Link: https://www.sciencedirect.com/science/article/pii/S0953620523003874?via%3Dihub
Titel: Biomarker patterns in patients with cardiogenic shock versus septic shock
Auteur: Elma J. Peters, Martin S. Frydland, Christian Hassager, Lieuwe D.J. Bos, Lonneke A. van Vught, Olaf L. Cremer, Jacob E. Møller, Bert-Jan H. van den Born, Alexander P.J. Vlaar and Jose P.S. Henriques
Magazine: international journal of cardiology heart & vasculature
Link: https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S2352906724000903?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2352906724000903%3Fshowall%3Dtrue&referrer=https:%2F%2Fpubmed.ncbi.nlm.nih.gov%2F
Titel: Subphenotypes in critical illness: a priori biological rationale is key
Auteur: Rombout B E van Amstel, Olaf L Cremer, Lonneke A van Vught, Lieuwe D J Bos; MARS consortium
Magazine: Intensive care medicine
Link: https://link.springer.com/article/10.1007/s00134-023-07273-8
Titel: Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines
Auteur: Julie Van Coillie, Tamas Pongracz, Tonci Šuštic, Wenjun Wang, Jan Nouta, Mathieu Le Gars, Sofie Keijzer, Federica Linty, Olvi Cristianawati, Jim B D Keijser, Remco Visser Lonneke A van Vught, Marleen A Slim, Niels van Mourik, Merel J Smit, Adam Sander, David E Schmidt, Maurice Steenhuis, Theo Rispens, Morten A Nielsen, Benjamin G Mordmüller, Alexander P J Vlaar, C Ellen van der Schoot, Ramon Roozendaal, Manfred Wuhrer
Magazine: iScience
Link: https://www.sciencedirect.com/science/article/pii/S2589004223016966?via%3Dihub
Titel: Towards personalized medicine: a scoping review of immunotherapy in sepsis
Auteur: https://link.springer.com/article/10.1186/s13054-024-04964-6
Magazine: Critical Care
Begin- en eindpagina: 183-
Link: https://link.springer.com/article/10.1186/s13054-024-04964-6
Titel: The predictive value of the modified early warning score for admission to the intensive care unit in patients with a hematologic malignancy - A multicenter observational study
Auteur: Niels van Mourik, Jesse J Oomen, Lonneke A van Vught, Bart J Biemond, Walter M van den Bergh, Nicole M A Blijlevens, Alexander P J Vlaar, Marcella C A Müller
Magazine: Intensive and Critical Care Nursing
Link: https://www.sciencedirect.com/science/article/pii/S0964339723001039?via%3Dihub
Titel: Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes
Auteur: Rombout B E van Amstel, Jason N Kennedy, Brendon P Scicluna, Lieuwe D J Bos, Hessel Peters-Sengers, Joe M Butler, Eddie Cano-Gamez, Julian C Knight, Alexander P J Vlaar, Olaf L Cremer, Derek C Angus, Tom van der Poll, Christopher W Seymour, Lonneke A van Vught; MARS Consortium
Magazine: Intensive Care Medicine
Begin- en eindpagina: 1360-1369
Link: https://link.springer.com/article/10.1007/s00134-023-07239-w
Titel: Time since SARS-CoV-2 infection and humoral immune response following BNT162b2 mRNA vaccination
Auteur: Brent Appelman, Karlijn van der Straten, A H Ayesha Lavell, Michiel Schinkel, Marleen A Slim, Meliawati Poniman, Judith A Burger, Melissa Oomen, Khadija Tejjani, Alexander P J Vlaar, W Joost Wiersinga, Yvo M Smulders, Lonneke A van Vught, Rogier W Sanders, Marit J van Gils, Marije K Bomers, Jonne J Sikkens; Amsterdam UMC COVID-19 S3/HCW study group
Magazine: eBioMedicine
Link: https://www.sciencedirect.com/science/article/pii/S2352396421003820?via%3Dihub
Titel: Inflammatory subphenotypes previously identified in ARDS are associated with mortality at intensive care unit discharge: a secondary analysis of a prospective observational study
Auteur: Marleen A. Slim, Rombout B. E. van Amstel, Lieuwe D. J. Bos, Olaf L. Cremer, MARS Consortium, W. Joost Wiersinga, Tom van der Poll & Lonneke A. van Vught
Magazine: Critical Care
Link: https://link.springer.com/article/10.1186/s13054-024-04929-9
Titel: Towards personalized medicine: a scoping review of immunotherapy in sepsis
Auteur: Marleen A Slim, Niels van Mourik, Lieke Bakkerus, Katherine Fuller, Lydia Acharya, Tatiana Giannidis, Joanna C Dionne, Simon J W Oczkowski, Mihai G Netea, Peter Pickkers, Evangelos J Giamarellos-Bourboulis, Marcella C A Müller, Tom van der Poll, W Joost Wiersinga; ImmunoSep Consortium; Alexander P J Vlaar, Lonneke A van Vught
Magazine: Critical Care
Link: https://ccforum.biomedcentral.com/articles/10.1186/s13054-024-04964-6
Titel: Blood leukocyte transcriptomes in Gram-positive and Gram-negative community-acquired pneumonia
Auteur: Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Joe Butler, Lonneke A van Vught, Katie L Burnham, Emma E Davenport, Julian C Knight, Olaf L Cremer, Marcus J Schultz, Marc M J Bonten, Brendon P Scicluna , Tom van der Poll; MARS consortium
Magazine: European Respiratory Journal
Link: https://publications.ersnet.org/content/erj/59/3/2101856?implicit-login=true%26943
Titel: Integrating biology into clinical trial design
Auteur: Rombout B E van Amstel, Lonneke A van Vught, Lieuwe D J Bos
Magazine: Current opinion Critical Care
Begin- en eindpagina: 26-33
Link: https://link.springer.com/article/10.1007/s00134-023-07239-w
Titel: Biological Subphenotypes of Acute Respiratory Distress Syndrome Show Prognostic Enrichment in Mechanically Ventilated Patients without Acute Respiratory Distress Syndrome
Auteur: Nanon F L Heijnen, Laura A Hagens, Marry R Smit, Olaf L Cremer, David S Y Ong, Tom van der Poll, Lonneke A van Vught, Brendon P Scicluna, Ronny M Schnabel, Iwan C C van der Horst, Marcus J Schultz, Dennis C J J Bergmans, Lieuwe D J Bos
Magazine: American Journal of Respiratory and Critical Care Medicine
Begin- en eindpagina: 1503-1511
Link: https://www.atsjournals.org/doi/10.1164/rccm.202006-2522OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Titel: Personalised immunotherapy in sepsis: a scoping review protocol
Auteur: Marleen A Slim, Niels van Mourik, Joanna C Dionne, Simon J W Oczkowski, M G Netea, Peter Pickkers, Evangelos J Giamarellos-Bourboulis, Marcella C A Müller, Tom van der Poll, W Joost Wiersinga, Alexander P J Vlaar, Lonneke A van Vught
Magazine: BMJ open
Link: https://bmjopen.bmj.com/content/12/5/e060411.long
Titel: Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes
Auteur: Rombout B E van Amstel, Jason N Kennedy, Brendon P Scicluna Lieuwe D J Bos, Hessel Peters-Sengers, Joe M Butler, Eddie Cano-Gamez, Julian C Knight, Alexander P J Vlaar, Olaf L Cremer, Derek C Angus, Tom van der Poll, Christopher W Seymour, Lonneke A van Vught
Magazine: Intensive Care Medicine
Link: https://link.springer.com/article/10.1007/s00134-023-07239-w
Titel: Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study
Auteur: Hessel Peters-Sengers, Joe M Butler, Fabrice Uhel, Marcus J Schultz, Marc J Bonten, Olaf L Cremer, Brendon P Scicluna, Lonneke A van Vught, Tom van der Poll; MARS consortium
Magazine: Intensive Care Medicine
Begin- en eindpagina: 92-102
Link: https://link.springer.com/article/10.1007/s00134-021-06574-0
Titel: A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern
Auteur: Marit J van Gils, Hugo D G van Willigen, Elke Wynberg, Alvin X Han, Karlijn van der Straten, Judith A Burger, Meliawati Poniman, Melissa Oomen, Khadija Tejjani, Joey H Bouhuijs, Anouk Verveen, Romy Lebbink, Maartje Dijkstra, Brent Appelman, A H Ayesha Lavell, Tom G Caniels, Ilja Bontjer, Lonneke A van Vught, Alexander P J Vlaar, Jonne J Sikkens, Marije K Bomers, Colin A Russell, Neeltje A Kootstra, Rogier W Sanders, Maria Prins, Godelieve J de Bree, Menno D de Jong; RECoVERED Study Group
Magazine: Cell Reports Medicine
Link: https://www.sciencedirect.com/science/article/pii/S266637912100358X?via%3Dihub
Titel: Cross-reactive antibodies after SARS-CoV-2 infection and vaccination
Auteur: Marloes Grobben, Karlijn van der Straten, Philip Jm Brouwer, Mitch Brinkkemper, Pauline Maisonnasse, Nathalie Dereuddre-Bosquet, Brent Appelman, Ah Ayesha Lavell, Lonneke A van Vught, Judith A Burger, Meliawati Poniman, Melissa Oomen, Dirk Eggink, Tom Pl Bijl, Hugo Dg van Willigen, Elke Wynberg, Bas J Verkaik, Orlane Ja Figaroa, Peter J de Vries, Tessel M Boertien; Amsterdam UMC COVID-19 S3/HCW study group; Marije K Bomers, Jonne J Sikkens, Rogier W Sanders, Marit J van Gils
Magazine: Elife
Link: https://elifesciences.org/articles/70330
Titel: The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees
Auteur: Julie Van Coillie, Tamas Pongracz, Johann Rahmöller, Hung-Jen Chen, Chiara Elisabeth Geyer, Lonneke A van Vught, Jana Sophia Buhre, Tonci Šuštic Thijs Luc Junior van Osch, Maurice Steenhuis, Willianne Hoepel, Wenjun Wang 2, Anne Sophie Lixenfeld 7, Jan Nouta 2, Sofie Keijzer 8, Federica Linty 1, Remco Visser 1, Mads Delbo Larsen, Emily Lara Martin, Inga Künsting, Selina Lehrian, Vera von Kopylow, Carsten Kern, Hanna Bele Lunding, Menno de Winther, Niels van Mourik, Theo Rispens
Magazine: eBioMedicine
Link: https://www.sciencedirect.com/science/article/pii/S2352396422005904?via%3Dihub

Kenmerken

Projectnummer:
09150161910033
Looptijd: 100%
2021
2025
Gerelateerde programma's:
Gerelateerde subsidieronde:
Projectleider en penvoerder:
dr. L.A. van Vught
Verantwoordelijke organisatie:
Universitair Medisch Centrum Utrecht