The role of brown adipose tissue in cholesterol metabolism: implications for the treatment of atherosclerosis
Ontrafelen van het effect van bruin vet op de vaatwand
Bruin vet is een nieuw aangrijpingspunt in de strijd tegen cardiometabole ziekten. Dit project richt zich op het ontrafelen van het mechanisme hoe activatie van bruin vet aderverkalking voorkomt.
Dissecting the effects of brown adipose tissue on the vessel wall
Brown adipose tissue is an emerging target to combat cardiometabolic disease. This project aims to dissect the mechnism(s) how brown adipose tissue activation attenuates atherosclerosis.
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Titel: Gut microbiota play a key role in the induction of beneficial effects of butyrate on host energy metabolism
Auteur: Yanan Wang
Auteur: Yanan Wang
Titel: Gut microbiota play a key role in the induction of beneficial effects of butyrate on host energy metabolism
Auteur: Zhuang Li
Auteur: Zhuang Li
Titel: Anti-PCSK9 treatment enhances beneficial effects of brown fat activation on cholesterol metabolism in APOE*3-Leiden.CETP mice
Auteur: Enchen Zhou
Auteur: Enchen Zhou
Titel: Bile acid sequestrant colesevelam enhances beneficial effects of brown fat activation on cholesterol metabolism in APOE*3-Leiden.CETP mice
Auteur: Yanan Wang
Auteur: Yanan Wang
Titel: Butyrate via the gut-brain neural circuit?reduces appetite and activates brown adipose tissue
Auteur: Yanan Wang
Auteur: Yanan Wang
Titel: Bile acid sequestrant colesevelam enhances beneficial effects of brown fat activation on cholesterol metabolism and atherosclerosis development in APOE*3-Leiden.CETP mice
Auteur: Enchen Zhou
Auteur: Enchen Zhou
Titel: Anti-PCSK9 treatment enhances beneficial effects of brown fat activation on cholesterol metabolism in APOE*3-Leiden.CETP mice
Auteur: Enchen Zhou
Auteur: Enchen Zhou
Titel: Lipopolysaccharide reduces hepatic cholesteryl ester transfer protein expression by activating Kupffer cells
Auteur: Yanan Wang
Auteur: Yanan Wang
Titel: Butyrate via the gut-brain neuronal circuit reduces appetite and activates brown adipose tissue
Auteur: Li, Zhuang, Kooijman, Sander, Yi, Chunxia, Chuang, Chih Kit, Berbée, Jimmy F.P., Willems Van Dijk, Ko, Groen, Albert K., Rensen, Patrick C.N., Wang, Yanan
Magazine: Atherosclerosis
Auteur: Li, Zhuang, Kooijman, Sander, Yi, Chunxia, Chuang, Chih Kit, Berbée, Jimmy F.P., Willems Van Dijk, Ko, Groen, Albert K., Rensen, Patrick C.N., Wang, Yanan
Magazine: Atherosclerosis
Titel: Butyrate via the gut-brain neural circuit reduces appetite and activates brown adipose tissue
Auteur: Wang, Y., Li, Z., Yi, C.X., Katiraei, S., Kooijman, S., Zhou, E., Chung, C., Gao, Y., van den Heuvel, J.K., Meijer, O.C., Berbée, J.F.P., Heijink, M., Giera, M., Willems van Dijk, J.A.P., Groen, A.K., Rensen, P.C.N.
Magazine: Atherosclerosis
Auteur: Wang, Y., Li, Z., Yi, C.X., Katiraei, S., Kooijman, S., Zhou, E., Chung, C., Gao, Y., van den Heuvel, J.K., Meijer, O.C., Berbée, J.F.P., Heijink, M., Giera, M., Willems van Dijk, J.A.P., Groen, A.K., Rensen, P.C.N.
Magazine: Atherosclerosis
Titel: Anti-Pcsk9 Treatment Enhances Beneficial Effects Of Brown Fat Activation On Cholesterol Metabolism In Apoe*3-Leiden.Cetp Mice
Auteur: Zhou, E., Li, Z., Choukoud, A., Berbée, J.F.P., Kooijman, S., Rensen, P.C.N., Wang, Y.
Magazine: Atherosclerosis
Auteur: Zhou, E., Li, Z., Choukoud, A., Berbée, J.F.P., Kooijman, S., Rensen, P.C.N., Wang, Y.
Magazine: Atherosclerosis
Titel: Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development
Auteur: Zhou, Enchen, Hoeke, Geerte, Li, Zhuang, Eibergen, Arthur C, Schonk, Amber W, Koehorst, Martijn, Boverhof, Renze, Havinga, Rick, Kuipers, Folkert, Coskun, Tamer, Boon, Mariëtte R, Groen, Albert K, Rensen, Patrick C N, Berbée, Jimmy F P, Wang, Yanan
Magazine: Cardiovascular Research
Auteur: Zhou, Enchen, Hoeke, Geerte, Li, Zhuang, Eibergen, Arthur C, Schonk, Amber W, Koehorst, Martijn, Boverhof, Renze, Havinga, Rick, Kuipers, Folkert, Coskun, Tamer, Boon, Mariëtte R, Groen, Albert K, Rensen, Patrick C N, Berbée, Jimmy F P, Wang, Yanan
Magazine: Cardiovascular Research
Titel: Statin treatment potentiates the lipid-lowering and anti-atherogenic effect of bat activation by accelerating lipoprotein remnant clearance
Auteur: Hoeke, Geerte, Wang, Yanan, Van Dam, Andrea, Mol, Isabel, Van Den Berg, Susan, Groen, Albert, Rensen, Patrick, Berbée, Jimmy, Boon, Mariëtte
Magazine: Atherosclerosis
Auteur: Hoeke, Geerte, Wang, Yanan, Van Dam, Andrea, Mol, Isabel, Van Den Berg, Susan, Groen, Albert, Rensen, Patrick, Berbée, Jimmy, Boon, Mariëtte
Magazine: Atherosclerosis
Titel: Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis
Auteur: Hoeke, Geerte, Wang, Yanan, van Dam, Andrea D., Mol, Isabel M., Gart, Eveline, Klop, Henk G., van den Berg, Susan M., Pieterman, Elsbet H., Princen, Hans M.G., Groen, Albert K., Rensen, Patrick C.N., Berbée, Jimmy F.P., Boon, Mariëtte R.
Magazine: Atherosclerosis
Auteur: Hoeke, Geerte, Wang, Yanan, van Dam, Andrea D., Mol, Isabel M., Gart, Eveline, Klop, Henk G., van den Berg, Susan M., Pieterman, Elsbet H., Princen, Hans M.G., Groen, Albert K., Rensen, Patrick C.N., Berbée, Jimmy F.P., Boon, Mariëtte R.
Magazine: Atherosclerosis
Titel: The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1
Auteur: Herrera Moro Chao, Daniela, Wang, Yanan, Foppen, Ewout, Ottenhoff, Roelof, van Roomen, Cindy, Parlevliet, Edwin T., van Eijk, Marco, Verhoek, Marri, Boot, Rolf, Marques, Andre R., Scheij, Saskia, Mirzaian, Mina, Kooijman, Sander, Jansen, Kirstin, Wang, Dawei, Mergen, Clarita, Seeley, Randy J., Tschöp, Matthias H., Overkleeft, Herman, Rensen, Patrick C.N., Kalsbeek, Andries, Aerts, Johannes M.F.G., Yi, Chun-Xia
Magazine: Diabetes
Auteur: Herrera Moro Chao, Daniela, Wang, Yanan, Foppen, Ewout, Ottenhoff, Roelof, van Roomen, Cindy, Parlevliet, Edwin T., van Eijk, Marco, Verhoek, Marri, Boot, Rolf, Marques, Andre R., Scheij, Saskia, Mirzaian, Mina, Kooijman, Sander, Jansen, Kirstin, Wang, Dawei, Mergen, Clarita, Seeley, Randy J., Tschöp, Matthias H., Overkleeft, Herman, Rensen, Patrick C.N., Kalsbeek, Andries, Aerts, Johannes M.F.G., Yi, Chun-Xia
Magazine: Diabetes
Titel: FXR activation normalizes dyslipidemia and alleviates obesity in western-type diet–fed APOE*3-Leiden.CETP transgenic mice
Auteur: Paalvast, Y., Zhou, E., Mulder, N.L., Koehorst, M., Boverhof, R., Willems van Dijk, K., Rensen, P.C.N., Kuivenhoven, J.A., Kremoser, C., Wang, Y., Kuipers, F., Groen, A.K., de Boer, J.F.
Magazine: Atherosclerosis
Auteur: Paalvast, Y., Zhou, E., Mulder, N.L., Koehorst, M., Boverhof, R., Willems van Dijk, K., Rensen, P.C.N., Kuivenhoven, J.A., Kremoser, C., Wang, Y., Kuipers, F., Groen, A.K., de Boer, J.F.
Magazine: Atherosclerosis
Titel: Inhibition of ?24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution
Auteur: Körner, Andreas, Zhou, Enchen, Müller, Christoph, Mohammed, Yassene, Herceg, Sandra, Bracher, Franz, Rensen, Patrick C. N., Wang, Yanan, Mirakaj, Valbona, Giera, Martin
Magazine: PNAS
Auteur: Körner, Andreas, Zhou, Enchen, Müller, Christoph, Mohammed, Yassene, Herceg, Sandra, Bracher, Franz, Rensen, Patrick C. N., Wang, Yanan, Mirakaj, Valbona, Giera, Martin
Magazine: PNAS
Titel: Bile acid sequestrant colesevelam enhances beneficial effects of brown fat activation on cholesterol metabolism in APOE*3-Leiden.CETP mice
Auteur: Zhou, E., Hoeke, G., Eibergen, A.C., Wang, Z., Havinga, R.H., Groen, A.K., Boon, M.R., Rensen, P.C.N., Berbee, J.F.P., Wang, Y.
Magazine: Atherosclerosis
Auteur: Zhou, E., Hoeke, G., Eibergen, A.C., Wang, Z., Havinga, R.H., Groen, A.K., Boon, M.R., Rensen, P.C.N., Berbee, J.F.P., Wang, Y.
Magazine: Atherosclerosis
Titel: In vivo and in silico dynamics of the development of Metabolic Syndrome
Auteur: Rozendaal, Yvonne J. W., Wang, Yanan, Paalvast, Yared, Tambyrajah, Lauren L., Li, Zhuang, Willems van Dijk, Ko, Rensen, Patrick C. N., Kuivenhoven, Jan A., Groen, Albert K., Hilbers, Peter A. J., van Riel, Natal A. W.
Magazine: PLoS Computational Biology
Auteur: Rozendaal, Yvonne J. W., Wang, Yanan, Paalvast, Yared, Tambyrajah, Lauren L., Li, Zhuang, Willems van Dijk, Ko, Rensen, Patrick C. N., Kuivenhoven, Jan A., Groen, Albert K., Hilbers, Peter A. J., van Riel, Natal A. W.
Magazine: PLoS Computational Biology
Titel: Computational modelling of energy balance in individuals with Metabolic Syndrome
Auteur: Rozendaal, Yvonne J. W., Wang, Yanan, Hilbers, Peter A. J., van Riel, Natal A. W.
Magazine: BMC Systems Biology
Auteur: Rozendaal, Yvonne J. W., Wang, Yanan, Hilbers, Peter A. J., van Riel, Natal A. W.
Magazine: BMC Systems Biology
Titel: Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit
Auteur: Li, Zhuang, Yi, Chun-Xia, Katiraei, Saeed, Kooijman, Sander, Zhou, Enchen, Chung, Chih Kit, Gao, Yuanqing, van den Heuvel, José K, Meijer, Onno C, Berbée, Jimmy F P, Heijink, Marieke, Giera, Martin, Willems van Dijk, Ko, Groen, Albert K, Rensen, Patrick C N, Wang, Yanan
Magazine: Gut
Link: http://dx.doi.org/10.1136/gutjnl-2017-314050
Auteur: Li, Zhuang, Yi, Chun-Xia, Katiraei, Saeed, Kooijman, Sander, Zhou, Enchen, Chung, Chih Kit, Gao, Yuanqing, van den Heuvel, José K, Meijer, Onno C, Berbée, Jimmy F P, Heijink, Marieke, Giera, Martin, Willems van Dijk, Ko, Groen, Albert K, Rensen, Patrick C N, Wang, Yanan
Magazine: Gut
Link: http://dx.doi.org/10.1136/gutjnl-2017-314050
Titel: CETP (Cholesteryl Ester Transfer Protein) Concentration A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease
Auteur: Blauw, Lisanne L., Li-Gao, Ruifang, Noordam, Raymond, de Mutsert, Renée, Trompet, Stella, Berbée, Jimmy F.P., Wang, Yanan, van Klinken, Jan B., Christen, Tim, van Heemst, Diana, Mook-Kanamori, Dennis O., Rosendaal, Frits R., Jukema, J. Wouter, Rensen, Patrick C.N., Willems van Dijk, Ko
Magazine: Circulation: Cardiovascular Genetics
Auteur: Blauw, Lisanne L., Li-Gao, Ruifang, Noordam, Raymond, de Mutsert, Renée, Trompet, Stella, Berbée, Jimmy F.P., Wang, Yanan, van Klinken, Jan B., Christen, Tim, van Heemst, Diana, Mook-Kanamori, Dennis O., Rosendaal, Frits R., Jukema, J. Wouter, Rensen, Patrick C.N., Willems van Dijk, Ko
Magazine: Circulation: Cardiovascular Genetics
Titel: Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile
Auteur: Blauw, Lisanne L., Noordam, Raymond, Soidinsalo, Sebastian, Blauw, C. Alexander, Li-Gao, Ruifang, de Mutsert, Renée, Berbée, Jimmy F. P., Wang, Yanan, van Heemst, Diana, Rosendaal, Frits R., Jukema, J. Wouter, Mook-Kanamori, Dennis O., Würtz, Peter, Willems van Dijk, Ko, Rensen, Patrick C. N.
Magazine: European Journal of Human Genetics
Auteur: Blauw, Lisanne L., Noordam, Raymond, Soidinsalo, Sebastian, Blauw, C. Alexander, Li-Gao, Ruifang, de Mutsert, Renée, Berbée, Jimmy F. P., Wang, Yanan, van Heemst, Diana, Rosendaal, Frits R., Jukema, J. Wouter, Mook-Kanamori, Dennis O., Würtz, Peter, Willems van Dijk, Ko, Rensen, Patrick C. N.
Magazine: European Journal of Human Genetics
Titel: Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis
Auteur: Hoeke, Geerte, Wang, Yanan, van Dam, Andrea D., Mol, Isabel M., Gart, Eveline, Klop, Henk G., van den Berg, Susan M., Pieterman, Elsbet H., Princen, Hans M.G., Groen, Albert K., Rensen, Patrick C.N., Berbée, Jimmy F.P., Boon, Mariëtte R.
Magazine: Atherosclerosis
Auteur: Hoeke, Geerte, Wang, Yanan, van Dam, Andrea D., Mol, Isabel M., Gart, Eveline, Klop, Henk G., van den Berg, Susan M., Pieterman, Elsbet H., Princen, Hans M.G., Groen, Albert K., Rensen, Patrick C.N., Berbée, Jimmy F.P., Boon, Mariëtte R.
Magazine: Atherosclerosis
Titel: Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis
Auteur: Hoeke, Geerte, Wang, Yanan, van Dam, Andrea D., Mol, Isabel M., Gart, Eveline, Klop, Henk G., van den Berg, Susan M., Pieterman, Elsbet H., Princen, Hans M.G., Groen, Albert K., Rensen, Patrick C.N., Berbée, Jimmy F.P., Boon, Mariëtte R.
Magazine: Atherosclerosis
Auteur: Hoeke, Geerte, Wang, Yanan, van Dam, Andrea D., Mol, Isabel M., Gart, Eveline, Klop, Henk G., van den Berg, Susan M., Pieterman, Elsbet H., Princen, Hans M.G., Groen, Albert K., Rensen, Patrick C.N., Berbée, Jimmy F.P., Boon, Mariëtte R.
Magazine: Atherosclerosis
Titel: Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80(+)Clec4f(+)Vsig4(+)Ly6C(-) Kupffer Cell Subsets
Auteur: van der Tuin, Sam J. L., Li, Zhuang, Berbée, Jimmy F. P., Verkouter, Inge, Ringnalda, Linda E., Neele, Annette E., van Klinken, Jan B., Rensen, Sander S., Fu, Jingyuan, de Winther, Menno P. J., Groen, Albert K., Rensen, Patrick C. N., Willems van Dijk, Ko, Wang, Yanan
Magazine: Journal of the American Heart Association
Auteur: van der Tuin, Sam J. L., Li, Zhuang, Berbée, Jimmy F. P., Verkouter, Inge, Ringnalda, Linda E., Neele, Annette E., van Klinken, Jan B., Rensen, Sander S., Fu, Jingyuan, de Winther, Menno P. J., Groen, Albert K., Rensen, Patrick C. N., Willems van Dijk, Ko, Wang, Yanan
Magazine: Journal of the American Heart Association