The role of DNA damage and mitochondrial function in vascular, immune and neurological ageing
Age-related vascular diseases can be prevented
The world population is getting older and older. Unfortunately this increased life expectancy is generally associated by so-called age-related vascular diseases, such as dementia, heart infarct and stroke. However, these age-related chronic disorders can be delayed or even prevented by interference with common critical mechanisms underlying these diseases. Neurodegenerative and cardiovascular diseases share an underlying, mechanistic framework with involvement of increased oxidative stress, inflammation and insulin resistance.
Unrepaired DNA damage
In this project the researchers have strong indications that vascular ageing is caused by accumulation of unrepaired DNA damage and mitochondrial dysfunction in the vessel wall, which both increase with age. The project therefore proposes that age-related chronic disorders, despite their very diverse symptom profiles, share vascular ageing as common factor. These events induce progressive aging, inflammation and functional loss of the vessel wall, which eventually will manifest as cardiovascular dysfunction or neurodegeneration, two hallmarks of ageing.
International collaboration of researchers
In this Dutch-Brazilian NWO-FAPESP project, experts in the field of ageing, DNA damage and repair, mitochondrial dysfunction and cardiovascular inflammation will collaborate to establish this age-related cardiovascular and neurodegenerative disease axis, to detect signs of (accelerated) ageing at an earliest possible stage, and intend to design precision medicine. To do so they will combine cutting edge technologies.
Reducing age-related diseases in the future
The insights gained in this project will be used to design new biomarkers of vascular ageing and for new therapeutic measures to turn back the harmful causes. By targeting a unique common mechanism in vascular ageing we expect that this project will help to reduce these age-related diseases thus improving quality of life for the elderly, and bringing the vista of healthy ageing within reach.
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Auteur: Stefens SJ
Link: https://pure.eur.nl/en/publications/molecular-mechanisms-of-vascular-aging-and-aneurysm-formation-tow/
Auteur: Nagenborg J, Jin H, Ruder AV, Temmerman L, Mees B, Schalkwijk C, Müller-Klieser D, Berg T, Goossens P, Donners MMPC, Biessen EAL
Magazine: Frontiers in Immunology
Link: https://doi.org/10.3389/fimmu.2023.1165306
Auteur: Stefens SJM, van Vliet N, IJpma A, Burger J, Li Y, van Heijningen PM, Lindeman JHN, Majoor-Krakauer D, Verhagen HJM, Kanaar R, Essers J, van der Pluijm I
Magazine: Nature partner journal on Aging
Link: https://doi.org/10.1038/s41514-024-00154-4
Auteur: Ruder AV, Temmerman L, van Dommelen JMA, Nagenborg J, Lu C, Sluimer JC, Goossens P, Biessen EAL
Magazine: Frontiers in Immunology
Link: https://doi.org/10.3389/fimmu.2023.1078591
Auteur: Fontaine MAC, Jin H, Gagliardi M, Rousch M, Wijnands E, Stoll M, Li X, Schurgers L, Reutelingsperger C, Schalkwijk C, van den Akker NMS, Molin DGM, Gullestad L, Eritsland J, Hoffman P, Skjelland M, Andersen GØ, Aukrust P, Karel J, Smirnov E, Halvorsen B, Temmerman L, Biessen EAL
Magazine: Advanced Science
Link: https://doi.org/10.1002/advs.202203053
Auteur: Ruder AV, Wetzels SMW, Temmerman L, Biessen EAL, Goossens P
Magazine: Cardiovascular Research
Begin- en eindpagina: 2033-2045
Link: https://doi.org/10.1093/cvr/cvad069
Auteur: Basso PJ, Rocha CRR, Biessen EAL, van der Pluijm I, Menck CFM, Câmara NOS
Magazine: Frontiers in Immunology
Link: https://doi.org/10.3389/fimmu.2022.1034689
Auteur: Stefens SJM, van der Linden J, Heredia-Genestar JM, Brandt RMC, Barnhoorn S, Nieuwenhuizen-Bakker I, van Vliet N, Odijk JHM, Ridwan Y, Stuijts D, Batenburg M, Hoeijmakers JHJ, Kanaar R, Essers J, van der Pluijm I
Magazine: Aging Cell
Link: https://doi.org/10.1111/acel.70062