Selective targeting of FXR isoforms as treatment of non-alcoholic steatohepatitis.
Miljoenen mensen wereldwijd lijden aan de onbekende leverziekte niet-alcoholische steatohepatitis, met een hoog
risico op het ontwikkelen van leverfalen en kanker. Er zijn geen medicijnen voorhanden. De onderzoekers zullen
door selectieve activatie van de Farnesoid X Receptor onderzoeken of een hoog effectieve therapie kan worden
ontwikkeld.
Producten
Titel: Protein Condensation in the Nuclear Receptor Family; Implications for Transcriptional Output
Auteur: Monique D Appelman 1, Elle E Hollaar 1, Jurian Schuijers 1, Saskia W C van Mil 2
Link: https://link.springer.com/chapter/10.1007/978-3-031-11836-4_14
Auteur: Monique D Appelman 1, Elle E Hollaar 1, Jurian Schuijers 1, Saskia W C van Mil 2
Link: https://link.springer.com/chapter/10.1007/978-3-031-11836-4_14
Titel: Ablation of liver Fxr results in an increased colonic mucus barrier in mice
Auteur: Noortje Ijssennagger 1, Kristel S van Rooijen 1, Stefanía Magnúsdóttir 1, José M Ramos Pittol 1 2, Ellen C L Willemsen 1, Marcel R de Zoete 3, Matthijs J D Baars 1, Paul B Stege 3, Carolina Colliva 4, Roberto Pellicciari 4, Sameh A Youssef 5, Alain de Bruin 6 7, Yvonne Vercoulen 1, Folkert Kuipers 6, Saskia W C van Mil 1
Magazine: JHEP Rep
Begin- en eindpagina: 1-11
Link: https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S2589555921001208?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589555921001208%3Fshowall%3Dtrue&referrer=https:%2F%2Fpubmed.ncbi.nlm.nih.gov%2F
Auteur: Noortje Ijssennagger 1, Kristel S van Rooijen 1, Stefanía Magnúsdóttir 1, José M Ramos Pittol 1 2, Ellen C L Willemsen 1, Marcel R de Zoete 3, Matthijs J D Baars 1, Paul B Stege 3, Carolina Colliva 4, Roberto Pellicciari 4, Sameh A Youssef 5, Alain de Bruin 6 7, Yvonne Vercoulen 1, Folkert Kuipers 6, Saskia W C van Mil 1
Magazine: JHEP Rep
Begin- en eindpagina: 1-11
Link: https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S2589555921001208?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589555921001208%3Fshowall%3Dtrue&referrer=https:%2F%2Fpubmed.ncbi.nlm.nih.gov%2F
Titel: Human liver organoids: From generation to applications
Auteur: Marta B Afonso 1, Vanda Marques 1, Saskia W C van Mil 2, Cecilia M P Rodrigues 1
Magazine: Hepatology
Begin- en eindpagina: 1432-1451
Link: https://journals.lww.com/hep/fulltext/2024/06000/human_liver_organoids__from_generation_to.23.aspx
Auteur: Marta B Afonso 1, Vanda Marques 1, Saskia W C van Mil 2, Cecilia M P Rodrigues 1
Magazine: Hepatology
Begin- en eindpagina: 1432-1451
Link: https://journals.lww.com/hep/fulltext/2024/06000/human_liver_organoids__from_generation_to.23.aspx
Titel: The plasma lipidome varies with the severity of metabolic dysfunction-associated steatotic liver disease
Auteur: Clément J F Heymann 1, Anne Linde Mak 2, Adriaan G Holleboom 2, Joanne Verheij 3, Ronit Shiri-Sverdlov 4 5, Saskia W C van Mil 6, Maarten E Tushuizen 7, Ger H Koek 5 8, Aldo Grefhorst 9
Magazine: lipids health dis
Begin- en eindpagina: 1-13
Link: https://link.springer.com/article/10.1186/s12944-024-02380-x
Auteur: Clément J F Heymann 1, Anne Linde Mak 2, Adriaan G Holleboom 2, Joanne Verheij 3, Ronit Shiri-Sverdlov 4 5, Saskia W C van Mil 6, Maarten E Tushuizen 7, Ger H Koek 5 8, Aldo Grefhorst 9
Magazine: lipids health dis
Begin- en eindpagina: 1-13
Link: https://link.springer.com/article/10.1186/s12944-024-02380-x
Titel: The farnesoid X receptor activates transcription independently of RXR at non-canonical response elements
Auteur: Suzanne W van der Veen 1, Jelmer J Dijkstra 2 3, Ellen C L Willemsen 1, René Houtman 4, Alexandra Milona 1 5, Nikolas Marchet 6, Maureen Spit 1, Danielle Hollman 1, Fried J T Zwartkruis 1, Michiel Vermeulen 2 3, Jose M Ramos Pittol 6, Saskia W C van Mil 1
Magazine: Nucleic Acids Research
Begin- en eindpagina: 1-13
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC11879013/pdf/gkae1214.pdf
Auteur: Suzanne W van der Veen 1, Jelmer J Dijkstra 2 3, Ellen C L Willemsen 1, René Houtman 4, Alexandra Milona 1 5, Nikolas Marchet 6, Maureen Spit 1, Danielle Hollman 1, Fried J T Zwartkruis 1, Michiel Vermeulen 2 3, Jose M Ramos Pittol 6, Saskia W C van Mil 1
Magazine: Nucleic Acids Research
Begin- en eindpagina: 1-13
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC11879013/pdf/gkae1214.pdf
Titel: Post-Translational Modifications of FXR; Implications for Cholestasis and Obesity-Related Disorders
Auteur: Monique D Appelman 1, Suzanne W van der Veen 1, Saskia W C van Mil 1
Magazine: Front Endocrinol
Begin- en eindpagina: 1-13
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC8503269/pdf/fendo-12-729828.pdf
Auteur: Monique D Appelman 1, Suzanne W van der Veen 1, Saskia W C van Mil 1
Magazine: Front Endocrinol
Begin- en eindpagina: 1-13
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC8503269/pdf/fendo-12-729828.pdf
Titel: Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids
Auteur: Koos de Wit 1, Ulrich Beuers 1, Anna Mukha 2, Edwin C A Stigter 2, M Can Gulersonmez 2, Jose M Ramos Pittol 2, Sabine Middendorp 3 4, R Bart Takkenberg 1, Saskia W C van Mil 2
Magazine: liver international
Begin- en eindpagina: 649-659
Link: https://onlinelibrary.wiley.com/doi/epdf/10.1111/liv.15491
Auteur: Koos de Wit 1, Ulrich Beuers 1, Anna Mukha 2, Edwin C A Stigter 2, M Can Gulersonmez 2, Jose M Ramos Pittol 2, Sabine Middendorp 3 4, R Bart Takkenberg 1, Saskia W C van Mil 2
Magazine: liver international
Begin- en eindpagina: 649-659
Link: https://onlinelibrary.wiley.com/doi/epdf/10.1111/liv.15491