Stereo Investigator Confocal SD for high-throughput 3D stereology and neuronal morphometry
De onderzoekers willen met een computergestuurde volautomatische microscoop de structuur van hersencellen in kaart brengen. Ze richten zich daarbij op aandoeningen die leiden tot een verstandelijke handicap of tot een psychiatrische aandoening. Ook zullen ze kijken hoe de hersencellen reageren op verschillende medicaties, om op die manier nieuwe of verbeterde therapieën te ontwikkelen.
Producten
Titel: A role for Bicaudal-D2 in radial cerebellar granule cell migration
Titel: Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment
Titel: Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments
Titel: Autoimmune Encephalitis in Postpartum Psychosis
Titel: Temporal and region-specific requirements of αCaMKII in spatial and contextual learning
Titel: Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice
Titel: PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex
Titel: Priming of microglia in a DNA-repair deficient model of accelerated aging
Titel: Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model
Titel: An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression
Titel: In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome
Titel: HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1
Titel: Rheb regulates mitophagy induced by mitochondrial energetic status
Titel: Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons
Titel: Conditional deletion of α-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning
Titel: TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice
Titel: Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i
Titel: Anatomical investigation of potential contacts between climbing fibers and cerebellar Golgi cells in the mouse
Titel: Neurofibromin regulates HCN activity in Parvalbumin-positive interneurons
Titel: Arc expression identifies the lateral amygdala fear memory trace
Titel: Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model
Titel: Large GABAergic neurons form a distinct subclass within the mouse dorsal cortex of the inferior colliculus with respect to intrinsic properties, synaptic inputs, sound responses, and projections
Titel: Epigenetic characterization of the FMR1 promoter in induced pluripotent stem cells from human fibroblasts carrying an unmethylated full mutation
Titel: Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency
Titel: Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders
Verslagen
Eindverslag
N/A