Targeting the Mesenchymal Cancer Cell Phenotype for Therapeutic Gain
De meeste kankerpatiënten gaan dood aan kwaadaardige uitzaaiingen, of doordat de patiënten ongevoelig zijn geworden voor chemotherapie. In dit project streven we ernaar om bestaande medicijnen een herbestemming te geven in dat deze selectief het gedrag van agressieve kankercellen veranderd naar niet-invasieve en therapiegevoelige kankercellen of in goedaardige vetcellen.
Producten
Titel: Opposing USP19 splice variants in TGF-ß signaling and TGF-ß-induced epithelial-mesenchymal transition of breast cancer cells.
Auteur: Zhang J, van Dinther M, Thorikay M, Gourabi BM, Kruithof BPT, Ten Dijke P
Magazine: Cell Molecular Life Sciences
Begin- en eindpagina: 43-
Link: https://link.springer.com/article/10.1007/s00018-022-04672-w
Auteur: Zhang J, van Dinther M, Thorikay M, Gourabi BM, Kruithof BPT, Ten Dijke P
Magazine: Cell Molecular Life Sciences
Begin- en eindpagina: 43-
Link: https://link.springer.com/article/10.1007/s00018-022-04672-w
Titel: Special issue: TGF-ß and epithelial-mesenchymal transition in cancer
Auteur: Peter ten Dijke, Kohei Miyazono, Carl-Henrik Heldin, Aristidis Moustakas
Magazine: Seminars in Cancer Biology
Begin- en eindpagina: 1-3
Link: https://pubmed.ncbi.nlm.nih.gov/38944133/
Auteur: Peter ten Dijke, Kohei Miyazono, Carl-Henrik Heldin, Aristidis Moustakas
Magazine: Seminars in Cancer Biology
Begin- en eindpagina: 1-3
Link: https://pubmed.ncbi.nlm.nih.gov/38944133/
Titel: LncRNA LITATS1 suppresses TGF-ß-induced EMT and cancer cell plasticity by potentiating TßRI degradation.
Auteur: Fan C, Wang Q, Kuipers TB, Cats D, Iyengar PV, Hagenaars SC, Mesker WE, Devilee P, Tollenaar RAEM, Mei H, Ten Dijke P.
Magazine: EMBO J.
Link: https://www.embopress.org/doi/full/10.15252/embj.2022112806
Auteur: Fan C, Wang Q, Kuipers TB, Cats D, Iyengar PV, Hagenaars SC, Mesker WE, Devilee P, Tollenaar RAEM, Mei H, Ten Dijke P.
Magazine: EMBO J.
Link: https://www.embopress.org/doi/full/10.15252/embj.2022112806
Titel: Ena/VASP-EVH1 inhibition prevents chemotaxis and metastasis by blocking the EVH1-WAVE2 interaction.
Auteur: Müller, M., Barone, M., Dinther, M. V., Motzny, K., Ren, J., Eichhorst, J., Albat, D., Chiha, S., Lehmann, M., Volkmer, R., Oschkinat, H., Schmalz, H. G., Ten Dijke, P., & Kühne, R.
Magazine: Proceedings of the National Academy of Sciences of the United States of America,
Begin- en eindpagina: 2423512122-
Auteur: Müller, M., Barone, M., Dinther, M. V., Motzny, K., Ren, J., Eichhorst, J., Albat, D., Chiha, S., Lehmann, M., Volkmer, R., Oschkinat, H., Schmalz, H. G., Ten Dijke, P., & Kühne, R.
Magazine: Proceedings of the National Academy of Sciences of the United States of America,
Begin- en eindpagina: 2423512122-
Titel: ERBIN limits epithelial cell plasticity via suppression of TGF-ß signaling
Auteur: Li, C., van der Zon, G., Ten Dijke, P., & Shen, T.
Magazine: FEBS letters
Begin- en eindpagina: 3103-3112
Link: https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70121
Auteur: Li, C., van der Zon, G., Ten Dijke, P., & Shen, T.
Magazine: FEBS letters
Begin- en eindpagina: 3103-3112
Link: https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70121
Titel: Zhang J, van der Zon G, Ma J, Mei H, Cabukusta B, Agaser CC, Madunic K, Wuhrer M, Zhang T, Ten Dijke P
Auteur: ST3GAL5-catalyzed gangliosides inhibit TGF-ß-induced epithelial-mesenchymal transition via TßRI degradation.
Magazine: EMBO J.
Link: https://www.embopress.org/doi/full/10.15252/embj.2021110553
Auteur: ST3GAL5-catalyzed gangliosides inhibit TGF-ß-induced epithelial-mesenchymal transition via TßRI degradation.
Magazine: EMBO J.
Link: https://www.embopress.org/doi/full/10.15252/embj.2021110553
Titel: EMT-related cell-matrix interactions are linked to states of cell unjamming in cancer spheroid invasion.
Auteur: van der Net, A., Rahman, Z., Bordoloi, A. D., Muntz, I., Ten Dijke, P., Boukany, P. E., & Koenderink, G. H.
Magazine: iScience
Begin- en eindpagina: 111424-
Link: https://www.sciencedirect.com/science/article/pii/S258900422402649X?via%3Dihub
Auteur: van der Net, A., Rahman, Z., Bordoloi, A. D., Muntz, I., Ten Dijke, P., Boukany, P. E., & Koenderink, G. H.
Magazine: iScience
Begin- en eindpagina: 111424-
Link: https://www.sciencedirect.com/science/article/pii/S258900422402649X?via%3Dihub
Titel: Harnessing epithelial-mesenchymal plasticity to boost cancer immunotherapy.
Auteur: Gu Y, Zhang Z, Ten Dijke P.
Magazine: Cell Mol Immunol
Begin- en eindpagina: 318-340
Link: https://www.nature.com/articles/s41423-023-00980-8
Auteur: Gu Y, Zhang Z, Ten Dijke P.
Magazine: Cell Mol Immunol
Begin- en eindpagina: 318-340
Link: https://www.nature.com/articles/s41423-023-00980-8
Titel: TGF-ß Type I Receptor Signaling in Melanoma Liver Metastases Increases Metastatic Outgrowth.
Auteur: Marvin DL, Dijkstra J, Zulfiqar RM, Vermeulen M, Ten Dijke P, Ritsma L.
Magazine: Int J Mol Sci.
Begin- en eindpagina: 8676-
Link: https://www.mdpi.com/1422-0067/24/10/8676
Auteur: Marvin DL, Dijkstra J, Zulfiqar RM, Vermeulen M, Ten Dijke P, Ritsma L.
Magazine: Int J Mol Sci.
Begin- en eindpagina: 8676-
Link: https://www.mdpi.com/1422-0067/24/10/8676
Titel: Targeting Oncofoetal Chondroitin Sulphate Allows Identification of Tumour-Derived Extracellular Vesicles. Journal of extracellular vesicles
Auteur: Enciso-Martinez, A., Løppke, C., Koene, J. J., Ebbelaar, J., van der Geest, M., Los, M., Boerrigter, E. P. E. M., Dagil, R., Gustavsson, T., Vidal-Calvo, E. E., van Leeuwen, T. G., Koning, R. I., van Es, N., Salanti, A., van der Pol, E., Nieuwland, R., Agerbæk, M. Ø., & Ten Dijke, P.
Magazine: Journal of extracellular vesicles
Begin- en eindpagina: 70106-
Link: https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.70106
Auteur: Enciso-Martinez, A., Løppke, C., Koene, J. J., Ebbelaar, J., van der Geest, M., Los, M., Boerrigter, E. P. E. M., Dagil, R., Gustavsson, T., Vidal-Calvo, E. E., van Leeuwen, T. G., Koning, R. I., van Es, N., Salanti, A., van der Pol, E., Nieuwland, R., Agerbæk, M. Ø., & Ten Dijke, P.
Magazine: Journal of extracellular vesicles
Begin- en eindpagina: 70106-
Link: https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.70106
Titel: LETS1 promotes TGF-ß-induced EMT and cancer cell migration by transcriptionally activating a TßR1-stabilizing mechanism
Auteur: Fan C, González-Prieto R, Kuipers TB, Vertegaal ACO, van Veelen PA, Mei H, Ten Dijke P
Magazine: Science Signaling
Link: https://www.science.org/doi/10.1126/scisignal.adf1947?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Auteur: Fan C, González-Prieto R, Kuipers TB, Vertegaal ACO, van Veelen PA, Mei H, Ten Dijke P
Magazine: Science Signaling
Link: https://www.science.org/doi/10.1126/scisignal.adf1947?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Titel: Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells.
Auteur: Gu Y, Zhang Z, Camps MGM, Ossendorp F, Wijdeven RH, Ten Dijke P.
Magazine: Science Advances
Link: https://www.science.org/doi/full/10.1126/sciadv.adf9915?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
Auteur: Gu Y, Zhang Z, Camps MGM, Ossendorp F, Wijdeven RH, Ten Dijke P.
Magazine: Science Advances
Link: https://www.science.org/doi/full/10.1126/sciadv.adf9915?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
Titel: Dynamic Visualization of TGF-ß/SMAD3 Transcriptional Responses in Single Living Cells.
Auteur: Marvin DL, You L, Bornes L, van Dinther M, Peters N, Dang H, Hakuno SK, Hornsveld M, Kranenburg O, van Rheenen J, Rohling JHT, Chien MP, Ten Dijke P, Ritsma L.
Magazine: Cancers
Begin- en eindpagina: 2508-2508
Link: https://www.mdpi.com/2072-6694/14/10/2508
Auteur: Marvin DL, You L, Bornes L, van Dinther M, Peters N, Dang H, Hakuno SK, Hornsveld M, Kranenburg O, van Rheenen J, Rohling JHT, Chien MP, Ten Dijke P, Ritsma L.
Magazine: Cancers
Begin- en eindpagina: 2508-2508
Link: https://www.mdpi.com/2072-6694/14/10/2508
Titel: Interstitial flow potentiates TGF-ß/Smad-signaling activity in lung cancer spheroids in a 3D-microfluidic chip.
Auteur: Rahman Z, Bordoloi AD, Rouhana H, Tavasso M, van der Zon G, Garbin V, Ten Dijke P, Boukany PE
Magazine: Lab Chip
Begin- en eindpagina: 422-433
Link: https://pubs.rsc.org/en/content/articlelanding/2024/lc/d3lc00886j
Auteur: Rahman Z, Bordoloi AD, Rouhana H, Tavasso M, van der Zon G, Garbin V, Ten Dijke P, Boukany PE
Magazine: Lab Chip
Begin- en eindpagina: 422-433
Link: https://pubs.rsc.org/en/content/articlelanding/2024/lc/d3lc00886j
Titel: Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-ß/Smad signaling.
Auteur: Voytyuk, O., Ohata, Y., Moustakas, A., Ten Dijke, P., & Heldin, C. H.
Magazine: The Journal of biological Chemistry
Begin- en eindpagina: 107462-107462
Link: https://www.sciencedirect.com/science/article/pii/S002192582401963X?via%3Dihub
Auteur: Voytyuk, O., Ohata, Y., Moustakas, A., Ten Dijke, P., & Heldin, C. H.
Magazine: The Journal of biological Chemistry
Begin- en eindpagina: 107462-107462
Link: https://www.sciencedirect.com/science/article/pii/S002192582401963X?via%3Dihub
Titel: Inter-spheroid proximity and matrix remodeling determine cancer associated fibroblast mediated cancer cell invasion
Auteur: Mehta, P., Bordoloi, A. D., Ravensbergen, C., David, M. K. H., Mesker, W., Liefers, G. J., Ten Dijke, P., & Boukany, P. E
Magazine: Acta biomaterialia
Begin- en eindpagina: 350-361
Auteur: Mehta, P., Bordoloi, A. D., Ravensbergen, C., David, M. K. H., Mesker, W., Liefers, G. J., Ten Dijke, P., & Boukany, P. E
Magazine: Acta biomaterialia
Begin- en eindpagina: 350-361
Titel: Differential optineurin expression controls TGFß signaling and is a key determinant for metastasis of triple negative breast cancer.
Auteur: Liu S, van Dinther M, Hagenaars SC, Gu Y, Kuipers TB, Mei H, Gomez-Puerto MC, Mesker WE, Ten Dijke P.
Magazine: International Journal of Cancer
Begin- en eindpagina: 2594-2606
Link: https://onlinelibrary.wiley.com/doi/10.1002/ijc.34483
Auteur: Liu S, van Dinther M, Hagenaars SC, Gu Y, Kuipers TB, Mei H, Gomez-Puerto MC, Mesker WE, Ten Dijke P.
Magazine: International Journal of Cancer
Begin- en eindpagina: 2594-2606
Link: https://onlinelibrary.wiley.com/doi/10.1002/ijc.34483
Titel: TGF-ß signaling dynamics in epithelial-mesenchymal plasticity of cancer cells
Auteur: Chuannan Fan, LUMC
Link: https://hdl.handle.net/1887/3765351
Auteur: Chuannan Fan, LUMC
Link: https://hdl.handle.net/1887/3765351
Titel: Regulation of TGF-ß signaling and EMT in cancer progression
Auteur: Jing Zhang, LUMC
Link: https://hdl.handle.net/1887/3309700
Auteur: Jing Zhang, LUMC
Link: https://hdl.handle.net/1887/3309700
Titel: TGF-beta signaling in cancer
Auteur: Peter ten Dijke
Auteur: Peter ten Dijke
Titel: Interstitial flow enhances TGF-/SMAD signaling activity in A549 lung cancer spheroids in 3D microfluidic chip.
Auteur: Zaid Rahman, TuDelft
Auteur: Zaid Rahman, TuDelft
Titel: TGF-beta receptor signaling in cancer cell plasticity
Titel: LITATS1 suppresses TGF-ß-induced epithelial-mesenchymal transition by potentiating TßRI degradation
Auteur: Chuannan Fan
Auteur: Chuannan Fan
Titel: Targeting TGF-beta signaling in cancer
Auteur: Peter ten Dijke
Auteur: Peter ten Dijke
Titel: OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-ß type I receptor
Auteur: Chuannan Fan, LUMC
Auteur: Chuannan Fan, LUMC
Titel: TGF-beta receptor signaling in cancer progression
Auteur: Peter ten Dijke, LUMC
Auteur: Peter ten Dijke, LUMC
Titel: Challenges and opportunities for therapeutic targeting of TGF-beta in cancer
Auteur: Peter ten Dijke
Auteur: Peter ten Dijke
Titel: TGF-beta signaling in breast cancer progression
Auteur: Chuannan Fan
Auteur: Chuannan Fan
Titel: a continuous stream heterogeneous cancr cdell manipulation devie by combinin hydrodynalic fpocusing and insulator-based dielectrophoresis 9iDEP)
Auteur: Gurhan Ozkayar, TuDelft
Auteur: Gurhan Ozkayar, TuDelft
Titel: TGF-beta signaling and epithelial to mesenchymal transition of cancer cells
Auteur: Peter ten Dijke, Jing Zhang and Chuannan Fan
Auteur: Peter ten Dijke, Jing Zhang and Chuannan Fan
Titel: “Targeting TGF-b Receptor Signaling in Cancer”
Auteur: Peter Ten Dijk, LUMC
Auteur: Peter Ten Dijk, LUMC
Titel: Interstitil flow enhances TGF-beta/SMAD signaling in lung cancer phheroids in 3D-microfluidic chiop.
Auteur: Zaid Rahman, TuDelft
Auteur: Zaid Rahman, TuDelft
Titel: circTGFBR2(3-6) acts as an assembly platform for IGF2BP3 protein and TGFBR1 mRNA to enhance breast cancer cell plasticity
Auteur: Chuannan Fan
Auteur: Chuannan Fan
Titel: TGF-beta signaling in cancer cell plasticity
Auteur: Peter ten Dijke, LUMC.
Auteur: Peter ten Dijke, LUMC.
Titel: Long non-coding RNA LncSNAIL functions as an enhancer RNA to promote TGF-ß signaling
Auteur: Chuannan Fan
Auteur: Chuannan Fan
Titel: TGF-beta receptor signaling dynamics in cancer cell plasticity
Auteur: Peter ten Dijke
Link: https://www.kva.se/en/research-funding/nobel-symposia/nobel-symposia-2000-20xx/
Auteur: Peter ten Dijke
Link: https://www.kva.se/en/research-funding/nobel-symposia/nobel-symposia-2000-20xx/
Titel: TGF-beta receptor signaling dynamics in cancer cell plasticity
Auteur: Peter ten Dijke
Auteur: Peter ten Dijke
Titel: Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity
Auteur: Chuannan Fan
Auteur: Chuannan Fan
Titel: Long non-coding RNA LITATS1 suppresses cancer cell invasion by potentiating SMURF2-mediated TGF-ß type I receptor degradation
Auteur: Chuannan Fan
Auteur: Chuannan Fan
Titel: TGF-beta receptor signaling in cancer cell plasticity
Auteur: Peter ten Dijke
Link: https://english.ncu.edu.cn/info/1035/7381.htm
Auteur: Peter ten Dijke
Link: https://english.ncu.edu.cn/info/1035/7381.htm
Titel: Functional screens for potent modulators of TGF-ß/SMAD signalling potentiator in breast cancer cells
Auteur: Qian Wang, LUMC
Auteur: Qian Wang, LUMC
Titel: Label-free microfluidic sorting of circulating tumour cells: formal analysis and cell trapping experiments by using an insulator-based dielectrophoresis 9iDEP) device
Auteur: Gurhan Ozkayar, TuDelft
Auteur: Gurhan Ozkayar, TuDelft
Titel: Targeting TGF-beta receptor signaling in cancer
Auteur: Peter ten Dijke
Auteur: Peter ten Dijke
Titel: Functional screens for modulators of TGF-ß/SMAD signalling potentiator in breast cancer cells
Auteur: Qian Wang, LUMC
Auteur: Qian Wang, LUMC
Titel: Interplay between interstital flow and TGF-beta during lung cancer invasion of sheroids embedded in a a microfluidic chip
Auteur: Zaid Rahman, TuDelft
Auteur: Zaid Rahman, TuDelft
Titel: LITATS1 suppresses TGF-ß-induced epithelial-mesenchymal transition by potentiating TßRI degradation
Auteur: Chuannan Fan
Auteur: Chuannan Fan
Titel: LITATS1 suppresses TGF-ß-induced epithelial-mesenchymal transition by potentiating TßRI degradation
Auteur: Chuannan Fan
Auteur: Chuannan Fan
Titel: Interview of two cancer patients and Peter ten Dijke at wereldkankerdag about engagement of cancer patients and cancer researchers.
Link: https://www.lygature.org/news/patients-and-researchers-find-strength-each-other-during-world-cancer-day
Link: https://www.lygature.org/news/patients-and-researchers-find-strength-each-other-during-world-cancer-day
Titel: Peter ten Dijke (LUMC) organized a meeting for cancer patients and cancer patient organizations and advocates on the early detection and monitoring of cancer, including a talk on circulating cancer cells (part of Zon-MW grant).
Link: https://ccb.lumc.nl/news/oncode-meeting-patient-engagement-program-257
Link: https://ccb.lumc.nl/news/oncode-meeting-patient-engagement-program-257
Titel: Interview for Particpatiekompas on the successful interaction of cancer patient Niels Heine with cancer researcher Peter ten Dijke and his group.
Link: https://participatiekompas.nl/glunderende-samenwerking-tussen-onderzoeker-en-patientenvertegenwoordiger?utm_source=dmdelivery&utm_medium=email&utm_content=Sterk%20staaltje%20pati%C3%ABntbetrokkenheid%20bij%20fundamenteel%20onderzoek%20%7C%20image&utm_campaign=Nieuwsbrief%20Participatiekompas%20januari%202023
Link: https://participatiekompas.nl/glunderende-samenwerking-tussen-onderzoeker-en-patientenvertegenwoordiger?utm_source=dmdelivery&utm_medium=email&utm_content=Sterk%20staaltje%20pati%C3%ABntbetrokkenheid%20bij%20fundamenteel%20onderzoek%20%7C%20image&utm_campaign=Nieuwsbrief%20Participatiekompas%20januari%202023