A three dimensional look into autophagy

Cellen recyclen componenten en gevaarlijke structuren via een proces genaamd autofagie (zelf-eten). Autofagie voorkomt en geneest talloze ziekten. Om het te moduleren voor medische doeleinden, hebben we het mechanisme van dit proces bestudeerd en de functie van een aantal van de belangrijkste spelers onthuld. Belangrijk is dat we binnen dit Vici-project een nieuwe technologie hebben ontwikkeld, die het mogelijk maakt om van zeer dichtbij in 3D het mechanisme van autofagie te bekijken en zo een uniek hulpmiddel is om mechanische details te ontleden. Alles bij elkaar heeft dit project ons begrip van autofagie sterk verbeterd en zijn we een stap dichterbij gekomen om autofagie te moduleren ten behoeve van de menselijke gezondheid.

Producten

Titel: The Interaction between Nidovirales and Autophagy Components
Auteur: Cong, Yingying, Verlhac, Pauline, Reggiori, Fulvio
Magazine: Viruses
Titel: Cellular metabolism regulates contact sites of vacuoles with mitochondria
Auteur: Hönscher C Mari M Auffarth K Bohnert M Griffith J Geerts W van der Laan M Cabrera M Reggiori F Ungermann C
Magazine: Developmental Cell
Titel: Nanogold labeling of the yeast endosomal system for ultrastructural analyses
Auteur: Mari M Griffith J Reggiori F
Magazine: Journal of Visualized Experiments
Titel: Assays for the biochemical and ultrastructural measurement of selective and nonselective types of autophagy in the yeast Saccharomyces cerevisiae
Auteur: Soares-Guimaraes R, Delorme-Axford E, Klionsky DJ, Reggiori F,
Magazine: Methods (Elsevier)
Titel: Common phosphatidyl-ethanolamine pools are used for autophagy, and for phosphatidyl-choline and glycosylphosphatidylinositol anchor synthesis
Auteur: Wilson-Zbinden C, da Silveira dos Santos AX, Stoffel-Studer I, van der Vaart A, Hofmann K, Reggiori F, Riezman H, Claudine Kraft C, Peter P,
Magazine: Genetics
Titel: Coordination of Autophagosome–Lysosome Fusion by Atg8 Family Members
Auteur: Kriegenburg, Franziska, Ungermann, Christian, Reggiori, Fulvio
Magazine: Current Biology
Titel: Sorting the trash: Micronucleophagy gets selective
Auteur: Verlhac, Pauline, Reggiori, Fulvio
Magazine: Journal of Cell Biology
Titel: Retromer and the dynamin Vps1 cooperate in the retrieval of transmembrane proteins from vacuoles
Auteur: Artl H, Reggiori F, Ungermann C,
Magazine: Journal of Cell Science
Titel: Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
Auteur: Sánchez-Wandelmer, Jana, Kriegenburg, Franziska, Rohringer, Sabrina, Schuschnig, Martina, Gómez-Sánchez, Rubén, Zens, Bettina, Abreu, Susana, Hardenberg, Ralph, Hollenstein, David, Gao, Jieqiong, Ungermann, Christian, Martens, Sascha, Kraft, Claudine, Reggiori, Fulvio
Magazine: Nature Communications
Titel: Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores
Auteur: Gómez-Sánchez, Rubén, Rose, Jaqueline, Guimarães, Rodrigo, Mari, Muriel, Papinski, Daniel, Rieter, Ester, Geerts, Willie J., Hardenberg, Ralph, Kraft, Claudine, Ungermann, Christian, Reggiori, Fulvio
Magazine: Journal of Cell Biology
Titel: Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses
Auteur: Echavarria-Consuegra, Liliana, Smit, Jolanda M., Reggiori, Fulvio
Magazine: Open Biology
Titel: Using microbes as a key tool to unravel the mechanism of autophagy and the functions of the ATG proteins
Auteur: Mauthe, Mario, Reggiori, Fulvio
Magazine: Microbial Cell
Titel: Coronavirus nucleocapsid proteins assemble constitutively in high molecular oligomers
Auteur: Cong, Yingying, Kriegenburg, Franziska, de Haan, Cornelis A. M., Reggiori, Fulvio
Magazine: Scientific Reports
Titel: Monitoring the Formation of Autophagosomal Precursor Structures in Yeast Saccharomyces cerevisiae
Auteur: Gómez-Sánchez, R., Sánchez-Wandelmer, J., Reggiori, F.
Magazine: Methods in Enzymology
Titel: A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation
Auteur: Cui, Yixian, Parashar, Smriti, Zahoor, Muhammad, Needham, Patrick G., Mari, Muriel, Zhu, Ming, Chen, Shuliang, Ho, Hsuan-Chung, Reggiori, Fulvio, Farhan, Hesso, Brodsky, Jeffrey L., Ferro-Novick, Susan
Magazine: Science
Titel: Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy
Auteur: Grumati, Paolo, Morozzi, Giulio, Hölper, Soraya, Mari, Muriel, Harwardt, Marie-Lena IE, Yan, Riqiang, Müller, Stefan, Reggiori, Fulvio, Heilemann, Mike, Dikic, Ivan
Magazine: eLife
Titel: Amphisomes: Out of the autophagosome shadow
Auteur: Wanderlmer-Sanchez J Reggiori F
Magazine: EMBO Journal
Titel: Immuno- and correlative light microscopy-electron tomography methods for 3D protein localization in yeast
Auteur: Mari M Geerts W Reggiori F
Magazine: Traffic
Titel: Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis and TOR signaling
Auteur: Numrich J, Gulli M-P, Arlt H, Sardu A, Griffith J, Levine T, Engelbrecht-Vandré S, Reggiori F, DeVirgilio C, Ungermann C,
Magazine: Journal of Cell Science
Titel: ERES: sites for autophagosome biogenesis and maturation?
Auteur: Sanchez-Wandelmer J Ktistakis NT Reggiori F
Magazine: Journal of Cell Science
Titel: Assays to Monitor Autophagy Progression in Cell Cultures
Auteur: Orhon, Idil, Reggiori, Fulvio
Magazine: Cells
Titel: Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure
Auteur: Gao, Jieqiong, Langemeyer, Lars, Kümmel, Daniel, Reggiori, Fulvio, Ungermann, Christian
Magazine: eLife
Titel: Genetic aberrations in macroautophagy genes leading to diseases
Auteur: van Beek, Nienke, Klionsky, Daniel J., Reggiori, Fulvio
Magazine: Biochimica et Biophysica Acta
Titel: Emerging regulation and functions of autophagy
Auteur: Boya P Reggiori F Codogno P
Magazine: Nature Cell Biology
Titel: Lipid partitioning at the nuclear envelope controls membrane biogenesis
Auteur: Barbosa, A. D., Sembongi, H., Su, W.-M., Abreu, S., Reggiori, F., Carman, G. M., Siniossoglou, S.
Magazine: Molecular Biology of the Cell
Titel: Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation
Auteur: Abreu, Susana, Kriegenburg, Franziska, Gómez-Sánchez, Rubén, Mari, Muriel, Sánchez-Wandelmer, Jana, Skytte Rasmussen, Mads, Soares Guimarães, Rodrigo, Zens, Bettina, Schuschnig, Martina, Hardenberg, Ralph, Peter, Matthias, Johansen, Terje, Kraft, Claudine, Martens, Sascha, Reggiori, Fulvio
Magazine: EMBO Reports
Titel: Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Auteur: Mauthe, Mario, Orhon, Idil, Rocchi, Cecilia, Zhou, Xingdong, Luhr, Morten, Hijlkema, Kerst-Jan, Coppes, Robert P., Engedal, Nikolai, Mari, Muriel, Reggiori, Fulvio
Magazine: Autophagy
Titel: Regulation of lipid and membrane biogenesis by the acidic tail of the phosphatidate phosphatase Pah1p
Auteur: Karanasios E Barbosa AD Sembongi H Mari M Han G-S Reggiori F Carman GM Siniossoglou S
Magazine: Molecular Biology of the Cell
Titel: An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation
Auteur: Harner, Max E, Unger, Ann-Katrin, Geerts, Willie JC, Mari, Muriel, Izawa, Toshiaki, Stenger, Maria, Geimer, Stefan, Reggiori, Fulvio, Westermann, Benedikt, Neupert, Walter
Magazine: eLife
Titel: An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication
Auteur: Mauthe, Mario, Langereis, Martijn, Jung, Jennifer, Zhou, Xingdong, Jones, Alex, Omta, Wienand, Tooze, Sharon A., Stork, Björn, Paludan, Søren Riis, Ahola, Tero, Egan, Dave, Behrends, Christian, Mokry, Michal, de Haan, Cornelis, van Kuppeveld, Frank, Reggiori, Fulvio
Magazine: Journal of Cell Biology
Titel: Regulation of endoplasmic reticulum homeostasis by FAM134B-mediated selective autophagy
Auteur: Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katon I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I,
Magazine: Nature
Titel: Assessing the progression of autophagy pathways in different organisms and tissues
Auteur: Reffiori F, Codogno P
Magazine: Methods (Elsevier)
Titel: Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
Auteur: Shai, Nadav, Yifrach, Eden, van Roermund, Carlo W. T., Cohen, Nir, Bibi, Chen, IJlst, Lodewijk, Cavellini, Laetitia, Meurisse, Julie, Schuster, Ramona, Zada, Lior, Mari, Muriel C., Reggiori, Fulvio M., Hughes, Adam L., Escobar-Henriques, Mafalda, Cohen, Mickael M., Waterham, Hans R., Wanders, Ronald J. A., Schuldiner, Maya, Zalckvar, Einat
Magazine: Nature Communications
Titel: Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells
Auteur: Zielke, Svenja, Meyer, Nina, Mari, Muriel, Abou-El-Ardat, Khalil, Reggiori, Fulvio, van Wijk, Sjoerd J. L., Kögel, Donat, Fulda, Simone
Magazine: Cell Death and Disease
Titel: Ultrastructural Characterization of Membrane Rearrangements Induced by Porcine Epidemic Diarrhea Virus Infection
Auteur: Zhou, Xingdong, Cong, Yingying, Veenendaal, Tineke, Klumperman, Judith, Shi, Dongfang, Mari, Muriel, Reggiori, Fulvio
Magazine: Viruses
Titel: Autophagic processes in yeast: Mechanisms, machineries and regulation
Auteur: Klionsky, DJ Reggiori, F
Magazine: Genetics
Titel: ATG proteins: Are we always looking at autophagy?
Auteur: Mauthe, Mario, Reggiori, Fulvio
Magazine: Autophagy
Titel: Autophagosome Maturation and Fusion
Auteur: Reggiori, Fulvio, Ungermann, Christian
Magazine: Journal of Molecular Biology
Titel: Electron microscopy for ultrastructural analysis and protein localization in Saccharomyces cerevisiae
Auteur: Frankl, Andri, Mari, Muriel, Reggiori, Fulvio
Magazine: Microbial Cell
Titel: Probing aggrephagy using chemically-induced protein aggregates
Auteur: Janssen, Anne F. J., Katrukha, Eugene A., van Straaten, Wendy, Verlhac, Pauline, Reggiori, Fulvio, Kapitein, Lukas C.
Magazine: Nature Communications
Titel: Ultrastructural Characterization of Membrane Rearrangements Induced by Porcine Epidemic Diarrhea Virus Infection
Auteur: Zhou, Xingdong, Cong, Yingying, Veenendaal, Tineke, Klumperman, Judith, Shi, Dongfang, Mari, Muriel, Reggiori, Fulvio
Magazine: Viruses
Titel: Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk
Auteur: Lassen, Kara G., McKenzie, Craig I., Mari, Muriel, Murano, Tatsuro, Begun, Jakob, Baxt, Leigh A., Goel, Gautam, Villablanca, Eduardo J., Kuo, Szu-Yu, Huang, Hailiang, Macia, Laurence, Bhan, Atul K., Batten, Marcel, Daly, Mark J., Reggiori, Fulvio, Mackay, Charles R., Xavier, Ramnik J.
Magazine: Immunity
Titel: Hidden behind autophagy: The unconventional roles of the ATG proteins
Auteur: Bestebroer J V’kovski P Mauthe M Reggiori F
Magazine: Traffic
Titel: Progressive Motor Deficit is Mediated by the Denervation of Neuromuscular Junctions and Axonal Degeneration in Transgenic Mice Expressing Mutant (P301S) Tau Protein
Auteur: Yin, Zhuoran, Valkenburg, Femke, Hornix, Betty E., Mantingh-Otter, Ietje, Zhou, Xingdong, Mari, Muriel, Reggiori, Fulvio, Van Dam, Debby, Eggen, Bart J.L., De Deyn, Peter P., Boddeke, Erik
Magazine: Journal of Alzheimer's disease
Titel: Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation
Auteur: Eisenberg-Bord, Michal, Mari, Muriel, Weill, Uri, Rosenfeld-Gur, Eden, Moldavski, Ofer, Castro, Inês G., Soni, Krishnakant G., Harpaz, Nofar, Levine, Tim P., Futerman, Anthony H., Reggiori, Fulvio, Bankaitis, Vytas A., Schuldiner, Maya, Bohnert, Maria
Magazine: Journal of Cell Biology
Titel: A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles
Auteur: Gao, Jieqiong, Reggiori, Fulvio, Ungermann, Christian
Magazine: Journal of Cell Biology
Titel: The yeast Saccharomyces cerevisiae: An overview of methods to study autophagy progression
Auteur: Delorme-Axford E, Soares-Guimaraes R, Reggiori F, Klionsky DJ
Magazine: Methods (Elsevier)
Titel: Atg9 proteins, not so different after all
Auteur: Ungermann, Christian, Reggiori, Fulvio
Magazine: Autophagy
Titel: Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains
Auteur: Di Rienzo, M., Antonioli, M., Fusco, C., Liu, Y., Mari, M., Orhon, I., Refolo, G., Germani, F., Corazzari, M., Romagnoli, A., Ciccosanti, F., Mandriani, B., Pellico, M. T., De La Torre, R., Ding, H., Dentice, M., Neri, M., Ferlini, A., Reggiori, F., Kulesz-Martin, M., Piacentini, M., Merla, G., Fimia, G. M.

Snel naar

Kenmerken

Projectnummer:
91813606
Looptijd: 100%
2013
2019
Gerelateerde subsidieronde:
Projectleider en penvoerder:
Prof. dr. F. Reggiori PhD
Verantwoordelijke organisatie:
Universitair Medisch Centrum Groningen