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Towards preventing disease progression: studying inflammation in the earliest phases of Rheumatoid Arthritis

Projectomschrijving

Nog voordat de gewrichtsontsteking bij Reumatoïde Artritis (RA) aan de buitenkant te zien is begint de ziekte zich al te ontwikkelen. Het is in deze vroegste fase dat de ontsteking kan over gaan, waardoor de ziekte waarschijnlijk nog niet chronisch is. Het onderzoek heeft geleid tot kennis over de diagnostische en prognostische waarde van MRI in de vroegste fase van RA en in welke patiënten een MRI (meer)waarde heeft. Met name peesschede-ontsteking was een goede voorspeller voor het krijgen van RA, het is daarnaast een vroeg fenomeen en een kenmerk van RA. Ook is gebleken dat het van de voeten (naast de handen) weinig extra informatie biedt en dat de scantijd verkort kan worden door het onderzoek van de voeten weg te laten. Met behulp van de gegevens van dit onderzoek zijn we beter in staat mensen die RA aan het ontwikkelen zijn in heel vroege ziektefasen te herkennen, zelfs in de fasen als aan de buitenkant nog geen zwelling waarneembaar is.

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Titel: Automatic quantification of tenosynovitis on MRI of the wrist in patients with early arthritis: a feasibility study
Auteur: Aizenberg, Evgeni, Shamonin, Denis P., Reijnierse, Monique, van der Helm-van Mil, Annette H. M., Stoel, Berend C.
Magazine: European Radiology
Titel: Long-term outcome of Rheumatoid Arthritis defined according to the 2010-classification criteria
Auteur: Burgers LE, van Nies JA, Ho LY, de Rooy DP, Huizinga TW, van der Helm-van Mil AH.
Magazine: Annals of the Rheumatic Diseases
Titel: Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis
Auteur: van der Woude, Diane, van der Helm-van Mil, Annette H.M.
Magazine: Best Practice & Research Clinical Rheumatology
Titel: Disease-modifying antirheumatic drug-free sustained remission in rheumatoid arthritis: an increasingly achievable outcome with subsidence of disease symptoms
Auteur: Ajeganova, S, van Steenbergen, H W, van Nies, J A B, Burgers, L E, Huizinga, T W J, van der Helm-van Mil, A H M
Magazine: Annals of the Rheumatic Diseases
Titel: The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical
Auteur: Boeters, Debbie M., Mangnus, Lukas, Ajeganova, Sofia, Lindqvist, Elisabet, Svensson, Björn, Toes, René E. M., Trouw, Leendert A., Huizinga, Tom W. J., Berenbaum, Francis, Morel, Jacques, Rantapää-Dahlqvist, Solbritt, van der Helm-van Mil, Annette H. M.
Magazine: Arthritis Research & Therapy
Titel: MRI-detected subclinical joint inflammation is associated with radiographic progression
Auteur: Krabben, A, Stomp, W, van Nies, J A B, Huizinga, T W J, van der Heijde, D, Bloem, J L, Reijnierse, M, van der Helm-van Mil, A H M
Magazine: Annals of the Rheumatic Diseases
Titel: What is the value of musculoskeletal ultrasound in patients presenting with arthralgia to predict inflammatory arthritis development? A systematic literature review
Auteur: van den Berg, Rosaline, Ohrndorf, Sarah, Kortekaas, Marion C., van der Helm-van Mil, Annette H. M.
Magazine: Arthritis Research and Therapy
Titel: Sequence of joint tissue inflammation during rheumatoid arthritis development
Auteur: ten Brinck, R. M., van Steenbergen, H. W., van der Helm–van Mil, A. H. M.
Magazine: Arthritis Research & Therapy
Titel: Moderate use of alcohol is associated with lower levels of C reactive protein but not with less severe joint inflammation: a cross-sectional study in early RA and healthy volunteers
Auteur: Mangnus, Lukas, van Steenbergen, Hanna W, Nieuwenhuis, Wouter P, Reijnierse, Monique, van der Helm-van Mil, Annette H M
Magazine: Annals of Rheumatic Diseases
Titel: Autoantibodies to two novel peptides in seronegative and early rheumatoid arthritis
Auteur: De Winter, Liesbeth M., Hansen, Wendy L. J., van Steenbergen, Hanna W., Geusens, Piet, Lenaerts, Jan, Somers, Klaartje, Stinissen, Piet, van der Helm-van Mil, Annette H. M., Somers, Veerle
Magazine: Rheumatology
Titel: Fatigue in rheumatoid arthritis; a persistent problem: a large longitudinal study
Auteur: van Steenbergen, H. W., Tsonaka, R., Huizinga, T. W. J., Boonen, A., van der Helm-van Mil, A. H. M.
Magazine: Annals of the Rheumatic Diseases
Titel: The squeeze test of MCP joints: a scarcity of scientific data, especially from primary care
Auteur: van der Helm-van Mil, A H M
Magazine: Annals of the Rheumatic Diseases
Titel: Does a Genetic Variant inFOXO3APredict a Milder Course of Rheumatoid Arthritis?
Auteur: van Steenbergen, H. W., Rantapää-Dahlqvist, S., van Nies, J. A. B., Berglin, E., Huizinga, T. W. J., Gregersen, P. K., van der Helm-van Mil, A. H. M.
Magazine: Arthritis and Rheumatology
Titel: Validity of the rheumatoid arthritis MRI score applied to the forefeet using the OMERACT filter: a systematic literature review
Auteur: Dakkak, Yousra J, van der Heijde, Désirée M, Reijnierse, Monique, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: Are MRI-detected erosions specific for RA? A large explorative cross-sectional study
Auteur: Boeters, Debbie M, Nieuwenhuis, Wouter P, van Steenbergen, Hanna W, Reijnierse, Monique, Landewé, Robert B M, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients
Auteur: van Delft, Myrthe A. M., Verheul, Marije K., Burgers, Leonie E., Derksen, Veerle F. A. M., van der Helm-van Mil, Annette H. M., van der Woude, Diane, Huizinga, Tom W. J., Toes, René E. M., Trouw, Leendert A.
Magazine: Arthritis Research & Therapy
Titel: Osteoprotegerin as biomarker for persistence of rheumatoid arthritis
Auteur: van Steenbergen, Hanna W., van der Helm-van Mil, Annette H. M.
Magazine: Rheumatology
Titel: The effects of rheumatoid factor and anticitrullinated peptide antibodies on bone erosions in rheumatoid arthritis
Auteur: van Steenbergen, H W, Ajeganova, S, Forslind, K, Svensson, B, van der Helm-van Mil, A H M
Magazine: Annals of the Rheumatic Diseases
Titel: Evaluation of the diagnostic accuracy of hand and foot MRI for early Rheumatoid Arthritis
Auteur: Nieuwenhuis, Wouter P., van Steenbergen, Hanna W., Mangnus, Lukas, Newsum, Elize C., Bloem, Johan L., Huizinga, Tom W. J., le Cessie, Saskia, Reijnierse, Monique, van der Helm-van Mil, Annette H. M.
Magazine: Rheumatology
Titel: Concordance between inflammation at physical examination and on MRI in patients with early arthritis
Auteur: Krabben, A, Stomp, W, Huizinga, T W J, van der Heijde, D, Bloem, J L, Reijnierse, M, van der Helm-van Mil, A H M
Magazine: Annals of the Rheumatic Diseases
Titel: IL2RA is associated with persistence of rheumatoid arthritis
Auteur: van Steenbergen, H.W., van Nies, J.A.B., Ruyssen-Witrand, A., Huizinga, T.W.J., Cantagrel, Al., Berenbaum, F., van der Helm-van Mil, A.H.M.
Magazine: Arthritis Research & Therapy
Titel: The course of bone marrow edema in early undifferentiated and rheumatoid arthritis; a longitudinal MRI study on bone level
Auteur: Nieuwenhuis, Wouter P., van Steenbergen, Hanna W., Stomp, Wouter, Stijnen, Theo, Huizinga, Tom W.J., Bloem, Johan L., van der Heijde, Désirée, Reijnierse, Monique, van der Helm - van Mil, Annette H.M.
Magazine: Arthritis and Rheumatology
Titel: A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis
Auteur: Knevel, Rachel, de Rooy, Diederik PC, Saxne, Tore, Lindqvist, Elisabet, Leijsma, Martha K, Daha, Nina A, Koeleman, Bobby PC, Tsonaka, Roula, Houwing-Duistermaat, Jeanine J, Schonkeren, Joris JM, Toes, Rene EM, Huizinga, Tom WJ, Brouwer, Elisabeth, Wilson, Anthony G, van der Helm-van Mil, Annette HM
Magazine: Arthritis Research & Therapy
Titel: Older age is associated with more MRI-detected inflammation in hand and foot joints
Auteur: Nieuwenhuis, Wouter P., Mangnus, Lukas, van Steenbergen, Hanna W., Newsum, Elize C., Huizinga, Tom W. J., Reijnierse, Monique, van der Helm-van Mil, Annette H. M.
Magazine: Rheumatology
Titel: The anti-carbamylated protein antibody response is of overall low avidity despite extensive isotype switching
Auteur: van Delft, Myrthe A M, Verheul, Marije K, Burgers, Leonie E, Rantapää-Dahlqvist, Solbritt, van der Helm-van Mil, Annette H M, Huizinga, Tom W J, Toes, René E M, Trouw, Leendert A
Magazine: Rheumatology
Titel: Differential methylation within the major histocompatibility complex region in rheumatoid arthritis: a replication study
Auteur: van Steenbergen, Hanna W., Luijk, René, Shoemaker, Robert, Heijmans, Bastiaan T., Huizinga, Tom W. J., van der Helm-van Mil, Annette H. M.
Magazine: Rheumatology
Titel: Depression and anxiety associate with less remission after 1 year in rheumatoid arthritis
Auteur: Boer, Aleid C, Huizinga, Tom W J, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: MRI-detected osteitis is not associated with the presence or level of ACPA alone, but with the combined presence of ACPA and RF
Auteur: Boeters, Debbie M., Nieuwenhuis, Wouter P., Verheul, Marije K., Newsum, Elize C., Reijnierse, Monique, Toes, René E. M., Trouw, Leendert A., van der Helm-van Mil, Annette H. M.
Magazine: Arthritis Research & Therapy
Titel: Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: a systematic literature review and meta-analysis
Auteur: Dekkers, J S, Schoones, J W, Huizinga, T W, Toes, R E, van der Helm-van Mil, A H
Magazine: Annals of the Rheumatic Diseases
Titel: Risk estimation in rheumatoid arthritis—from bench to bedside
Auteur: van der Helm-van Mil, Annette H. M.
Magazine: Nature Reviews Rheumatology
Titel: How do general practitioners identify inflammatory arthritis? A cohort analysis of Dutch general practitioner electronic medical records
Auteur: Newsum, Elize C., de Waal, Margot W. M., van Steenbergen, Hanna W., Gussekloo, Jacobijn, van der Helm-van Mil, Annette H. M.
Magazine: Rheumatology
Titel: Is early remission associated with improved survival or is arthritis persistency associated with increased mortality in early arthritis? Comparisons with the general population
Auteur: Jessica A B van Nies, Annette H M van der Helm-van Mil
Magazine: Annals of the Rheumatic Diseases
Titel: Rheumatoid arthritis phenotype at presentation differs depending on the number of autoantibodies present
Auteur: Derksen, V F A M, Ajeganova, S, Trouw, L A, van der Helm-van Mil, A H M, Hafström, I, Huizinga, T W J, Toes, R E M, Svensson, B, van der Woude, D
Magazine: Annals of the Rheumatic Diseases
Titel: Evaluation of the predictive accuracy of MRI-detected erosions in hand and foot joints in patients with undifferentiated arthritis
Auteur: Boeters, Debbie M, Boer, Aleid C, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: Clinical expertise and its accuracy in differentiating arthralgia patients at risk for rheumatoid arthritis from other patients presenting with joint symptoms
Auteur: van Steenbergen, Hanna W., van der Helm-van Mil, Annette H. M.
Magazine: Rheumatology
Titel: Aiming for a shorter rheumatoid arthritis MRI protocol: can contrast-enhanced MRI replace T2 for the detection of bone marrow oedema?
Auteur: Stomp, Wouter, Krabben, Annemarie, van der Heijde, Désirée, Huizinga, Tom W. J., Bloem, Johan L., van der Helm-van Mil, Annette H. M., Reijnierse, Monique
Magazine: European Journal of Radiology
Titel: Body mass index and extent of MRI-detected inflammation: opposite effects in rheumatoid arthritis versus other arthritides and asymptomatic persons
Auteur: Mangnus, Lukas, Nieuwenhuis, Wouter P., van Steenbergen, Hanna W., Huizinga, Tom W. J., Reijnierse, Monique, van der Helm-van Mil, Annette H. M.
Magazine: Arthritis Research & Therapy
Titel: Does the presence of magnetic resonance imaging-detected osteitis at diagnosis with rheumatoid arthritis lower the risk for achieving disease-modifying antirheumatic drug-free sustained remission: results of a longitudinal study
Auteur: Burgers, L. E., Boeters, D. M., Reijnierse, M., van der Helm-van Mil, A. H. M.
Magazine: Arthritis Research & Therapy
Titel: Does psychological stress in patients with clinically suspect arthralgia associate with subclinical inflammation and progression to inflammatory arthritis?
Auteur: Boer, Aleid C., ten Brinck, Robin M., Evers, Andrea W. M., van der Helm-van Mil, Annette H. M.
Magazine: Arthritis Research & Therapy
Titel: Is Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Still a More Severe Disease Than Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis? A Longitudinal Cohort Study in Rheumatoid Arthritis Patients Diagnosed From 2000 Onwar
Auteur: Boer, Aleid C., Boonen, Annelies, van der Helm van Mil, Annette H. M.
Magazine: Arthritis Care & Research
Titel: Large joint involvement at first presentation with RA, an unfavourable feature: results of a large longitudinal study with functioning and DMARD-free sustained remission as outcomes
Auteur: Burgers, Leonie E, Boeters, Debbie M, van der Helm-van Mil, Annette HM
Magazine: Annals of the Rheumatic Diseases
Titel: Evaluation of Magnetic Resonance Imaging-Detected Tenosynovitis in the Hand and Wrist in Early Arthritis
Auteur: Nieuwenhuis, Wouter P., Krabben, Annemarie, Stomp, Wouter, Huizinga, Tom W. J., van der Heijde, Désirée, Bloem, Johan L., van der Helm-van Mil, Annette H. M., Reijnierse, Monique
Magazine: Arthritis and Rheumatology
Titel: Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia
Auteur: Ohrndorf, Sarah, Boer, Aleid C., Boeters, Debbie M., ten Brinck, Robin M., Burmester, Gerd-R., Kortekaas, Marion C., van der Helm-van Mil, Annette H. M.
Magazine: Arthritis Research & Therapy
Titel: Triple Positivity for Anti-Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti-Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis
Auteur: Verheul, Marije K., Böhringer, Stefan, van Delft, Myrthe A. M., Jones, Jonathan D., Rigby, William F. C., Gan, Ryan W., Holers, V. Michael, Edison, Jess D., Deane, Kevin D., Janssen, Koen M. J., Westra, Johanna, Brink, Mikael, Rantapää-Dahlqvist, Solbritt, Huizinga, Tom W. J., van der Helm-van Mil, Annette H. M., van der Woude, Diane, Toes, Rene E. M., Trouw, Leendert A.
Magazine: Arthritis and Rheumatology
Titel: Magnetic resonance imaging-detected inflammation is associated with functional disability in early arthritis—results of a cross-sectional study
Auteur: Burgers, Leonie E., Nieuwenhuis, Wouter P., van Steenbergen, Hanna W., Newsum, Elize C., Huizinga, Tom W. J., Reijnierse, Monique, le Cessie, Saskia, van der Helm-van Mil, Annette H. M.
Magazine: Rheumatology
Titel: Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis
Auteur: Knevel, Rachel, Klein, Kerstin, Somers, Klaartje, Ospelt, Caroline, Houwing-Duistermaat, Jeanine J, van Nies, Jessica A B, de Rooy, Diederik P C, de Bock, Laura, Kurreeman, Fina A S, Schonkeren, Joris, Stoeken-Rijsbergen, Gerrie, Helmer, Quinta, van der Linden, Michael P M, Kern, Marlena, Manjarrez-Orduno, Nataly, Rodriguez-Rodriquez, Luis, Stinissen, Piet, Huizinga, Tom W J, Toes, Rene E M, Gay, Steffen, Gregersen, Peter K, Somers, Veerle, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: Predicting the severity of joint damage in rheumatoid arthritis; the contribution of genetic factors
Auteur: van Steenbergen, Hanna W, Tsonaka, Roula, Huizinga, Tom WJ, le Cessie, Saskia, van der Helm-van Mil, Annette HM
Magazine: Annals of the Rheumatic Diseases
Titel: Studies on ageing and the severity of radiographic joint damage in rheumatoid arthritis
Auteur: Mangnus, Lukas, van Steenbergen, Hanna W., Lindqvist, Elisabet, Brouwer, Elisabeth, Reijnierse, Monique, Huizinga, Tom WJ, Gregersen, Peter K., Berglin, Ewa, Rantapää-Dahlqvist, Solbritt, van der Heijde, Désirée, Mil, Annette HM van der Helm-van
Magazine: Arthritis Research & Therapy
Titel: Effects of wearing high heels on the forefoot: an MRI evaluation
Auteur: Stomp, W, Krabben, A, van der Helm-van Mil, AHM, Reijnierse, M
Magazine: Scandinavian Journal of Rheumatology
Titel: The risk of individual autoantibodies, autoantibody combinations and levels for arthritis development in clinically suspect arthralgia
Auteur: ten Brinck, Robin M., van Steenbergen, Hanna W., van Delft, Myrthe A. M., Verheul, Marije K. , Toes, Rene E. M., Trouw, Leendert A., van der Helm – van Mil, Annette H. M.
Magazine: Rheumatology
Titel: Validation of the EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis
Auteur: Burgers, Leonie E., Siljehult, Filip, ten Brinck, Robin M., van Steenbergen, Hanna W., Landewé, Robert B. M., Rantapää-Dahlqvist, Solbritt, van der Helm-van Mil, Annette H. M.
Magazine: Rheumatology
Titel: Subclinical inflammation on MRI of hand and foot of anticitrullinated peptide antibody–negative arthralgia patients at risk for rheumatoid arthritis
Auteur: van Steenbergen, Hanna W, van Nies, Jessica AB, Huizinga, Tom WJ, Reijnierse, Monique, van der Helm-van Mil, Annette HM
Magazine: Arthritis Research & Therapy
Titel: Are Rheumatoid Arthritis Patients Discernible from Other Early Arthritis Patients Using 1.5T Extremity Magnetic Resonance Imaging? A Large Cross-sectional Study
Auteur: Stomp, Wouter, Krabben, Annemarie, van der Heijde, Désirée, Huizinga, Tom W.J., Bloem, Johan L., van der Helm-van Mil, Annette H.M., Reijnierse, Monique
Magazine: Journal of Rheumatology
Titel: Brief Report: Clinical Trials Aiming to Prevent Rheumatoid Arthritis Cannot Detect Prevention Without Adequate Risk Stratification: A Trial of Methotrexate Versus Placebo in Undifferentiated Arthritis as an Example
Auteur: Burgers, Leonie E., Allaart, Cornelia F., Huizinga, Tom W. J., van der Helm-van Mil, Annette H. M.
Magazine: Arthritis and Rheumatology
Titel: Bone mineral density loss in clinically suspect arthralgia is associated with subclinical inflammation and progression to clinical arthritis
Auteur: Mangnus, L, van Steenbergen, HW, Reijnierse, M, Kälvesten, J, van der Helm-Van Mil, AHM
Magazine: Scandinavian Journal of Rheumatology
Titel: Anti–Carbamylated Protein Antibodies and Higher Baseline Disease Activity in Rheumatoid Arthritis—A Replication Study in Three Cohorts: Comment on the Article by Truchetet et al
Auteur: Derksen, V. F. A. M., Westerlind, H., Saevarsdottir, S., Ajeganova, S., Trouw, L. A., Huizinga, T. W. J., Helm-van Mil, A. H. M., Knevel, R., Woude, D.
Magazine: Arthritis and Rheumatology
Titel: Does information on novel identified autoantibodies contribute to predicting the progression from undifferentiated arthritis to rheumatoid arthritis: a study on anti-CarP antibodies as an example
Auteur: Boeters, Debbie M., Trouw, Leendert A., van der Helm-van Mil, Annette H. M., van Steenbergen, Hanna W.
Magazine: Arthritis Research & Therapy
Titel: Clinical factors, anticitrullinated peptide antibodies and MRI-detected subclinical inflammation in relation to progression from clinically suspect arthralgia to arthritis
Auteur: van Steenbergen, Hanna W, Mangnus, Lukas, Reijnierse, Monique, Huizinga, Tom W J, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: Reappraisal of the diagnostic and prognostic value of morning stiffness in arthralgia and early arthritis: results from the Groningen EARC, Leiden EARC, ESPOIR, Leiden EAC and REACH
Auteur: van Nies, Jessica AB, Alves, Celina, Radix-Bloemen, Audrey LS, Gaujoux-Viala, Cécile, Huizinga, Tom WJ, Hazes, Johanna MW, Brouwer, Elisabeth, Fautrel, Bruno, Mil, Annette HM van der Helm-van
Magazine: Arthritis Research & Therapy
Titel: Functional limitations in the phase of clinically suspect arthralgia are as serious as in early clinical arthritis; a longitudinal study
Auteur: ten Brinck, Robin M, van Steenbergen, Hanna W, Mangnus, Lukas, Burgers, Leonie E, Reijnierse, Monique, Huizinga, Tom WJ, van der Helm-van Mil, Annette HM
Magazine: Annals of the Rheumatic Diseases
Titel: Differences in the symptomatic phase preceding ACPA-positive and ACPA-negative RA: a longitudinal study in arthralgia during progression to clinical arthritis
Auteur: Burgers, Leonie E, van Steenbergen, Hanna W, ten Brinck, Robin M, Huizinga, Tom WJ, van der Helm-van Mil, Annette HM
Magazine: Annals of the Rheumatic Diseases
Titel: The diagnostic accuracy of the squeeze test to identify arthritis: a cross-sectional cohort study
Auteur: van den Bosch, W B, Mangnus, L, Reijnierse, M, Huizinga, T W J, van der Helm-van Mil, A H M
Magazine: Annals of the Rheumatic Diseases
Titel: Inflammatory genes TNFa and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients
Auteur: Messemaker, T C, Mikkers, H M M, Huizinga, T W, Toes, R E M, van der Helm- van Mil, A H M, Kurreeman, F
Magazine: Genes and Immunity
Titel: Changes in the clinical presentation of patients with rheumatoid arthritis from the early 1990s to the years 2010: earlier identification but more severe patient reported outcomes
Auteur: Nieuwenhuis, Wouter P, de Wit, Maarten PT, Boonen, Annelies, van der Helm-van Mil, Annette HM
Magazine: Annals of the Rheumatic Diseases
Titel: The 2010 ACR/EULAR criteria are not sufficiently accurate in the early identification of autoantibody-negative rheumatoid arthritis: Results from the Leiden-EAC and ESPOIR cohorts
Auteur: Boeters, Debbie M., Gaujoux-Viala, Cécile, Constantin, Arnaud, van der Helm-van Mil, Annette H.M
Magazine: Seminars in Arthritis and Rheumatism
Titel: Characterising arthralgia in the preclinical phase of rheumatoid arthritis using MRI
Auteur: van Steenbergen, Hanna W, van Nies, Jessica A B, Huizinga, Tom W J, Bloem, Johan L, Reijnierse, Monique, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: Magnetic Resonance Imaging-Detected Features of Inflammation and Erosions in Symptom-Free Persons From the General Population
Auteur: Mangnus, L., van Steenbergen, H. W., Reijnierse, M., van der Helm-van Mil, A. H. M.
Magazine: Arthritis and Rheumatology
Titel: Longitudinal IP-10 Serum Levels Are Associated with the Course of Disease Activity and Remission in Patients with Rheumatoid Arthritis
Auteur: van Hooij, Anouk, Boeters, Debbie M., Tjon Kon Fat, Elisa M., van den Eeden, Susan J. F., Corstjens, Paul L. A. M., van der Helm-van Mil, Annette H. M., Geluk, Annemieke
Magazine: Clinical and Vaccine Immunology
Titel: Screening for two or three autoantibodies in persons at risk for RA: implications of current data for clinical practice
Auteur: ten Brinck, Robin M, Trouw, Leendert A, van der Helm-van Mil, Annette H M
Magazine: Rheumatology
Titel: What is the prevalence of MRI-detected inflammation and erosions in small joints in the general population? A collation and analysis of published data
Auteur: Mangnus, L., Schoones, J. W., van der Helm-van Mil, A. H. M.
Magazine: Annals of the Rheumatic Diseases
Titel: Anaemia to predict radiographic progression in rheumatoid arthritis.
Auteur: van Steenbergen HW, van Nies JA, van der Helm-van Mil AH.
Magazine: Annals of the Rheumatic Diseases
Titel: Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia
Auteur: ten Brinck, R. M., Toes, R. E. M., van der Helm–van Mil, A. H. M.
Magazine: Arthritis Research & Therapy
Titel: Using a reference when defining an abnormal MRI reduces false-positive MRI results—a longitudinal study in two cohorts at risk for rheumatoid arthritis
Auteur: Boer, Aleid C., Burgers, Leonie E., Mangnus, Lukas, ten Brinck, Robin M., Nieuwenhuis, Wouter P., van Steenbergen, Hanna W., Reijnierse, Monique, Huizinga, Tom W. J., van der Helm van Mil, Annette H. M.
Magazine: Rheumatology
Titel: MR signal intensity: staying on the bright side in MR image interpretation
Auteur: Bloem, Johan L, Reijnierse, Monique, Huizinga, Tom W J, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: Development of clinically apparent synovitis: a longitudinal study at the joint level during progression to inflammatory arthritis
Auteur: ten Brinck, Robin M, van Steenbergen, Hanna W, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: Strategies to predict rheumatoid arthritis development in at-risk populations
Auteur: Karlson, Elizabeth W., van Schaardenburg, Dirkjan, van der Helm-van Mil, Annette H.
Magazine: Rheumatology
Titel: What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?
Auteur: Dakkak, Y. J., Boeters, D. M., Boer, A. C., Reijnierse, M., van der Helm-van Mil, A. H. M.
Magazine: Arthritis Research & Therapy
Titel: Association of Valine and Leucine at HLA-DRB1 Position 11 With Radiographic Progression in Rheumatoid Arthritis, Independent of the Shared Epitope Alleles but Not Independent of Anti-Citrullinated Protein Antibodies
Auteur: van Steenbergen, H. W., Raychaudhuri, S., Rodríguez-Rodríguez, L., Rantapää-Dahlqvist, S., Berglin, E., Toes, R. E. M., Huizinga, T. W. J., Fernández-Gutiérrez, B., Gregersen, P. K., van der Helm-van Mil, A. H. M.
Magazine: Arthritis and Rheumatology
Titel: A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis
Auteur: van Steenbergen, Hanna W, Rodríguez-Rodríguez, Luis, Berglin, Ewa, Zhernakova, Alexandra, Knevel, Rachel, Ivorra-Cortés, Jose, Huizinga, Tom, Fernández-Gutiérrez, Benjamin, Gregersen, Peter K, Rantapää-Dahlqvist, Solbritt, van der Helm-van Mil, Annette
Magazine: Arthritis Research & Therapy
Titel: The use of MRI-detected synovitis to determine the number of involved joints for the 2010 ACR/EULAR classification criteria for Rheumatoid Arthritis – is it of additional benefit?
Auteur: Boer, Aleid C, Boeters, Debbie M, van der Helm-van Mil, Annette H M
Magazine: Annals of the Rheumatic Diseases
Titel: The association between anti-carbamylated protein (anti-CarP) antibodies and radiographic progression in early rheumatoid arthritis: a study exploring replication and the added value to ACPA and rheumatoid factor
Auteur: Ajeganova, S, van Steenbergen, H W, Verheul, M K, Forslind, K, Hafström, I, Toes, R E M, Huizinga, T W J, Svensson, B, Trouw, L A, van der Helm-van Mil, A H M
Magazine: Annals of the Rheumatic Diseases
Titel: Preventing progression from arthralgia to arthritis: targeting the right patients
Auteur: van Steenbergen, Hanna W., da Silva, José A. Pereira, Huizinga, Tom W. J., van der Helm-van Mil, Annette H. M.
Magazine: Nature Reviews Rheumatology
Titel: Anticitrullinated protein antibodies and rheumatoid factor are associated with increased mortality but with different causes of death in patients with rheumatoid arthritis: a longitudinal study in three European cohorts
Auteur: Ajeganova, S, Humphreys, J H, Verheul, M K, van Steenbergen, H W, van Nies, J A B, Hafström, I, Svensson, B, Huizinga, T W J, Trouw, L A, Verstappen, S M M, van der Helm-van Mil, A H M
Magazine: Annals of the Rheumatic Diseases
Titel: Identifying MRI-detected inflammatory features specific for rheumatoid arthritis: two-fold feature reduction maintains predictive accuracy in clinically suspect arthralgia patients
Auteur: Aizenberg, Evgeni, ten Brinck, Robin M., Reijnierse, Monique, van der Helm-van Mil, Annette H.M., Stoel, Berend C.
Magazine: Seminars in Arthritis and Rheumatism
Titel: Views on clinically suspect arthralgia: a focus group study
Auteur: Newsum, Elize C., van der Helm-van Mil, Annette H. M., Kaptein, Adrian A.
Magazine: International Journal of Rheumatology
Titel: Is joint pain in patients with arthralgia suspicious for progression to rheumatoid arthritis explained by subclinical inflammation? A cross-sectional MRI study
Auteur: Burgers, Leonie E, ten Brinck, Robin M, van der Helm-van Mil, Annette H M
Magazine: Rheumatology
Titel: What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review
Auteur: van Nies JA, Krabben A, Schoones JW, Huizinga TW, Kloppenburg M, van der Helm-van Mil AH.
Magazine: Annals of the Rheumatic Diseases
Titel: The Preclinical Phase of Rheumatoid Arthritis: What Is Acknowledged and What Needs to be Assessed?
Auteur: van Steenbergen HW, Huizinga TW, van der Helm-van Mil AH.
Magazine: Arthritis and Rheumatism

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Samenvatting van de aanvraag

Rheumatoid Arthritis (RA) is characterized by inflammation and destruction of joints. Despite recent improvements, the majority of RA-patients still have a chronic and destructive arthritis. The ultimate treatment strategy for RA targets inflammation before it has become chronic. However, the mechanisms underlying arthritis progression are unknown. Our data shows that the chance for remission reduces when inflammation persists. Most importantly, we observed that intervention in the very early phase (the first three months after arthritis onset) is associated with less arthritis persistency and less joint damage. This early period is denoted the “window of opportunity”. I want to unravel why short-lived inflammation is more often reversible than prolonged inflammation. I hypothesize that i) local inflammation is already present before clinical arthritis develops, ii) prolonged inflammation is more often persistent because of higher cumulative inflammatory loads, and iii) aberrant DNA methylation mediates arthritis progression. I propose to identify persons with symptoms of very recent-onset via our Early Arthritis Recognition Clinic and to follow persons with inflammatory artralgia or arthritis. We will quantify inflammation using MRI, since this method is most sensitive. I will i) evaluate whether inflammation is preclinically present in patients with inflammatory artralgia and identify determinants for progression to clinical arthritis, ii) determine cumulative inflammatory loads using serial MRIs in patients with very early arthritis to study associations with arthritis progression, iii) measure DNA methylation in synovial tissue and CD-4 positive T-cells and monocytes derived from peripheral blood of patients with very early arthritis to study associations with arthritis progression. Finally, MRI data of very early arthritis patients will be combined with our recently identified risk factors to achieve prognostication in the earliest stages of RA. This study builds on my previous work, bridging basic knowledge and phenotypic outcomes with the ultimate aim to improve the outcome of RA-patients.

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Kenmerken

Projectnummer:
91712313
Looptijd: 100%
Looptijd: 100 %
2012
2019
Gerelateerde subsidieronde:
Projectleider en penvoerder:
Dr. A. van der Helm-van Mil
Verantwoordelijke organisatie:
Leiden University Medical Center