A universal mechanical tester to study biotribology of tissue and biomaterial surfaces

Problems due to increased friction and wear occur mainly in an ageing and active population because of the stiffening of the tissue and imbalance of vital body fluids which lubricate the joints and organs. Often the loss in function is restored with the help of prosthesis and implants, which are often also accompanied with problems, due to an un-optimized biotic-abiotic interface. A universal mechanical tester together with a potentiostat/galvanostat will be used to solve some of the
important present day problems like the need of a biostable artificial meniscus, reduction of wear debris and metal ion release from artificial joints, wear-less non-fusion scoliosis correction device and better saliva and tear substitutes for patients with Sjögren’s syndrome.

Producten

Titel: Development of an in-vitro cornea-eyelid friction model to understand the role of glycerol and PRG4 (Lubricin) in preventing dry eyes?
Auteur: W. Woudstra, N. Sillevis Smitt-Kamminga, T.A. Schmidt, P.K. Sharma
Link: http://www.biointerfaces.ch/international/2016/
Titel: Development of an in vitro tongue-enamel friction model to mimic dry mouth and its correlation to dry mouth feel.
Auteur: Jeroen Vinke, Hans J. Kaper, Arjan Vissink Prashant K. Sharma
Titel: An ex vivo salivary lubrication system to mimic xerostomic conditions and to predict the lubricating properties of xerostomia relieving agents
Auteur: Vinke, Jeroen, Kaper, Hans J., Vissink, Arjan, Sharma, Prashant K.
Magazine: Scientific Reports
Titel: An in vitro study of cartilage–meniscus tribology to understand the changes caused by a meniscus implant
Auteur: Majd, Sara Ehsani, Rizqy, Aditya Iman, Kaper, Hans J., Schmidt, Tannin A., Kuijer, Roel, Sharma, Prashant K.
Magazine: Colloids and Surfaces B: Biointerfaces
Link: https://www.ncbi.nlm.nih.gov/pubmed/28437755
Titel: Notochordal cell matrix as a bioactive lubricant for the osteoarthritic joint
Auteur: de Vries, S. A. H., van Doeselaar, M., Kaper, H. J., Sharma, P. K., Ito, K.
Magazine: Scientific Reports
Titel: Implications of a polymer meniscus implant on knee tribology
Auteur: Ehsani Majd, Sara
Link: http://hdl.handle.net/11370/af7fbc21-db14-4ba8-92d4-0fcc5e9542f3

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Kenmerken

Projectnummer:
91112026
Looptijd: 100%
2012
2018
Gerelateerde programma's:
Gerelateerde subsidieronde:
Projectleider en penvoerder:
Dr. P.K. Sharma
Verantwoordelijke organisatie:
Universitair Medisch Centrum Groningen