A Smart Surveillance Strategy for Carbapenem-resistant Pseudomonas aeruginosa
The SAMPAN study investigated the Pseudomonas aeruginosa bacterium. First, methods were developed to detect this bacterium, especially the antibiotic-resistant strains, both in humans and in water, as it thrives well in moist environments.
Results
Carriage in people varied between Rotterdam, Rome, and Jakarta, ranging from 5 to 29% with possible seasonal effects. Antibiotic-resistant Pseudomonas aeruginosa was found most frequently in hospitalized patients in Jakarta. It was also detected in untreated hospital wastewater. In Rotterdam, it was no longer found after passing through a hospital wastewater treatment system. In rivers of all 3 cities, antibiotic-resistant Pseudomonas aeruginosa was detected at multiple time points, including strains that showed genetic similarities with those found in patients.
Follow-up
This threat and ongoing increase of antibiotic resistance urges for cross-border follow-up studies focusing on measures to prevent the spread of these pathogens.
Products
Title: Pseudomonas aeruginosa carriage and associated risk factors in healthy individuals and patients from Rotterdam, Rome, and Jakarta
Author: Anneloes van Veen, Selvi N Shahab, Amber Rijfkogel, Margreet C Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Anne F Voor in 't holt, Juliëtte A Severin; SAMPAN Consortium
Magazine: Scientific Reports
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC12279987/
Author: Anneloes van Veen, Selvi N Shahab, Amber Rijfkogel, Margreet C Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Anne F Voor in 't holt, Juliëtte A Severin; SAMPAN Consortium
Magazine: Scientific Reports
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC12279987/
Title: In search of the best method to detect carriage of carbapenem-resistant Pseudomonas aeruginosa in humans: a systematic review
Author: Selvi N Shahab, Anneloes van Veen, Andrea C Büchler, Yulia R Saharman, Anis Karuniawati, Margreet C Vos, Anne F Voor in 't holt, Juliëtte A Severin
Magazine: Ann Clin Microbiol Antimicrob
Link: https://link.springer.com/article/10.1186/s12941-024-00707-1
Author: Selvi N Shahab, Anneloes van Veen, Andrea C Büchler, Yulia R Saharman, Anis Karuniawati, Margreet C Vos, Anne F Voor in 't holt, Juliëtte A Severin
Magazine: Ann Clin Microbiol Antimicrob
Link: https://link.springer.com/article/10.1186/s12941-024-00707-1
Title: Development of a highly-sensitive method to detect the carriage of carbapenem-resistant Pseudomonas aeruginosa in humans
Author: Selvi N. Shahab, Anneloes van Veen, Nikita Kempenaars, Amber Rijfkogel, Heike Schmitt, Yulia R. Saharman, Margreet C. Vos, Anis Karuniawati, Juliëtte A. Severin; on behalf of the SAMPAN Consortium
Magazine: bioRxiv (preprint)
Link: https://www.biorxiv.org/content/10.1101/2024.08.27.609846v1
Author: Selvi N. Shahab, Anneloes van Veen, Nikita Kempenaars, Amber Rijfkogel, Heike Schmitt, Yulia R. Saharman, Margreet C. Vos, Anis Karuniawati, Juliëtte A. Severin; on behalf of the SAMPAN Consortium
Magazine: bioRxiv (preprint)
Link: https://www.biorxiv.org/content/10.1101/2024.08.27.609846v1
Title: Sources and Transmission Routes of Carbapenem-Resistant Pseudomonas aeruginosa: Study Design and Methodology of the SAMPAN Study
Author: Anneloes van Veen, Selvi N Shahab, Amber Rijfkogel, Anne F Voor in 't holt, Corné H W Klaassen, Margreet C Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Merel Kemper, Anniek E E de Jong, Sima Mohammadi, Valentine Renaud, Irena Kukavica-Ibrulj, Marianne Potvin, Guillaume Q Nguyen, Jeff Gauthier, Roger C Levesque, Heike Schmitt, Juliëtte A Severin
Magazine: Antibiotics (Basel)
Link: https://www.mdpi.com/2079-6382/14/1/94
Author: Anneloes van Veen, Selvi N Shahab, Amber Rijfkogel, Anne F Voor in 't holt, Corné H W Klaassen, Margreet C Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Merel Kemper, Anniek E E de Jong, Sima Mohammadi, Valentine Renaud, Irena Kukavica-Ibrulj, Marianne Potvin, Guillaume Q Nguyen, Jeff Gauthier, Roger C Levesque, Heike Schmitt, Juliëtte A Severin
Magazine: Antibiotics (Basel)
Link: https://www.mdpi.com/2079-6382/14/1/94
Title: Detection methods for carbapenem-resistant Pseudomonas aeruginosa in surface water and wastewater
Author: Selvi N Shahab, Anneloes van Veen, Merel A Kemper, Amber Rijfkogel, Margreet C Vos, Anis Karuniawati, Juliëtte A Severin, Heike Schmitt; on behalf of the SAMPAN Consortium
Magazine: Science of the Total Environment
Link: https://www.sciencedirect.com/science/article/pii/S0048969724082445?via%3Dihub
Author: Selvi N Shahab, Anneloes van Veen, Merel A Kemper, Amber Rijfkogel, Margreet C Vos, Anis Karuniawati, Juliëtte A Severin, Heike Schmitt; on behalf of the SAMPAN Consortium
Magazine: Science of the Total Environment
Link: https://www.sciencedirect.com/science/article/pii/S0048969724082445?via%3Dihub
Title: Stability of four carbapenem antibiotics in discs used for antimicrobial susceptibility testing
Author: Selvi N Shahab, Michiel L Bexkens, Nikita Kempenaars, Amber Rijfkogel, Anis Karuniawati, Margreet C Vos, Wil H F Goessens, Juliëtte A Severin; on behalf of the SAMPAN Consortium
Magazine: Journal of Applied Microbiology
Link: https://academic.oup.com/jambio/article/136/7/lxaf159/8173793?login=true
Author: Selvi N Shahab, Michiel L Bexkens, Nikita Kempenaars, Amber Rijfkogel, Anis Karuniawati, Margreet C Vos, Wil H F Goessens, Juliëtte A Severin; on behalf of the SAMPAN Consortium
Magazine: Journal of Applied Microbiology
Link: https://academic.oup.com/jambio/article/136/7/lxaf159/8173793?login=true
Title: Stability of four carbapenem antibiotics in discs used for antimicrobial susceptibility testing
Author: Selvi N Shahab, Michiel L Bexkens, Nikita Kempenaars, Amber Rijfkogel, Anis Karuniawati, Margreet C Vos, Wil H F Goessens, Juliëtte A Severin; on behalf of the SAMPAN Consortium
Magazine: Journal of Applied Microbiology
Link: https://academic.oup.com/jambio/article/136/7/lxaf159/8173793?login=true
Author: Selvi N Shahab, Michiel L Bexkens, Nikita Kempenaars, Amber Rijfkogel, Anis Karuniawati, Margreet C Vos, Wil H F Goessens, Juliëtte A Severin; on behalf of the SAMPAN Consortium
Magazine: Journal of Applied Microbiology
Link: https://academic.oup.com/jambio/article/136/7/lxaf159/8173793?login=true
Title: Detection methods for carbapenem-resistant Pseudomonas aeruginosa in surface water and wastewater
Author: Selvi N Shahab, Anneloes van Veen, Merel A Kemper, Amber Rijfkogel, Margreet C Vos, Anis Karuniawati, Juliëtte A Severin, Heike Schmitt; on behalf of the SAMPAN Consortium
Magazine: Science of the Total Environment
Link: https://www.sciencedirect.com/science/article/pii/S0048969724082445?via%3Dihub
Author: Selvi N Shahab, Anneloes van Veen, Merel A Kemper, Amber Rijfkogel, Margreet C Vos, Anis Karuniawati, Juliëtte A Severin, Heike Schmitt; on behalf of the SAMPAN Consortium
Magazine: Science of the Total Environment
Link: https://www.sciencedirect.com/science/article/pii/S0048969724082445?via%3Dihub
Title: Development of a highly-sensitive method to detect the carriage of carbapenem-resistant Pseudomonas aeruginosa in humans
Author: Selvi N. Shahab, Anneloes van Veen, Nikita Kempenaars, Amber Rijfkogel, Heike Schmitt, Yulia R. Saharman, Margreet C. Vos, Anis Karuniawati, Juliëtte A. Severin; on behalf of the SAMPAN Consortium
Magazine: bioRxiv (preprint)
Link: https://www.biorxiv.org/content/10.1101/2024.08.27.609846v1
Author: Selvi N. Shahab, Anneloes van Veen, Nikita Kempenaars, Amber Rijfkogel, Heike Schmitt, Yulia R. Saharman, Margreet C. Vos, Anis Karuniawati, Juliëtte A. Severin; on behalf of the SAMPAN Consortium
Magazine: bioRxiv (preprint)
Link: https://www.biorxiv.org/content/10.1101/2024.08.27.609846v1
Title: In search of the best method to detect carriage of carbapenem-resistant Pseudomonas aeruginosa in humans: a systematic review
Author: Selvi N Shahab, Anneloes van Veen, Andrea C Büchler, Yulia R Saharman, Anis Karuniawati, Margreet C Vos, Anne F Voor in 't holt, Juliëtte A Severin
Magazine: Ann Clin Microbiol Antimicrob
Link: https://link.springer.com/article/10.1186/s12941-024-00707-1
Author: Selvi N Shahab, Anneloes van Veen, Andrea C Büchler, Yulia R Saharman, Anis Karuniawati, Margreet C Vos, Anne F Voor in 't holt, Juliëtte A Severin
Magazine: Ann Clin Microbiol Antimicrob
Link: https://link.springer.com/article/10.1186/s12941-024-00707-1
Title: Sources and Transmission Routes of Carbapenem-Resistant Pseudomonas aeruginosa: Study Design and Methodology of the SAMPAN Study
Author: Anneloes van Veen, Selvi N Shahab, Amber Rijfkogel, Anne F Voor in 't holt, Corné H W Klaassen, Margreet C Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Merel Kemper, Anniek E E de Jong, Sima Mohammadi, Valentine Renaud, Irena Kukavica-Ibrulj, Marianne Potvin, Guillaume Q Nguyen, Jeff Gauthier, Roger C Levesque, Heike Schmitt, Juliëtte A Severin
Magazine: Antibiotics (Basel)
Link: https://www.mdpi.com/2079-6382/14/1/94
Author: Anneloes van Veen, Selvi N Shahab, Amber Rijfkogel, Anne F Voor in 't holt, Corné H W Klaassen, Margreet C Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Merel Kemper, Anniek E E de Jong, Sima Mohammadi, Valentine Renaud, Irena Kukavica-Ibrulj, Marianne Potvin, Guillaume Q Nguyen, Jeff Gauthier, Roger C Levesque, Heike Schmitt, Juliëtte A Severin
Magazine: Antibiotics (Basel)
Link: https://www.mdpi.com/2079-6382/14/1/94
Title: Pseudomonas aeruginosa carriage and associated risk factors in healthy individuals and patients from Rotterdam, Rome, and Jakarta
Author: Anneloes van Veen, Selvi N Shahab, Amber Rijfkogel, Margreet C Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Anne F Voor in 't holt, Juliëtte A Severin; SAMPAN Consortium
Magazine: Scientific Reports
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC12279987/
Author: Anneloes van Veen, Selvi N Shahab, Amber Rijfkogel, Margreet C Vos, Yulia Rosa Saharman, Anis Karuniawati, Silvia Zelli, Desy De Lorenzis, Giulia Menchinelli, Giulia De Angelis, Maurizio Sanguinetti, Anne F Voor in 't holt, Juliëtte A Severin; SAMPAN Consortium
Magazine: Scientific Reports
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC12279987/