Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s

Accumulation of the protein α-Synuclein in brain cells is characteristic of Parkinson's disease. However, we still do not understand why certain cells are vulnerable to this protein buildup while others are not. Additionally, we have limited knowledge of how and when disease processes manifest in different cell types.

Objective

The 4DPD-Omics consortium will use advanced molecular techniques to investigate which cell-specific mechanisms contribute to vulnerability to α-Synuclein protein accumulation and cell death.

Approach/Methodology

We will examine cells in Parkinson's disease model systems and postmortem brain tissue. We will generate a 4D atlas of the distribution of specific cell populations and the changes in cellular processes involved in protein accumulation.

Collaborative Partners

This international consortium consists of partners in Germany and Ireland, in addition to the Netherlands.

The Parkinson(ism) Association is an organization for patients with Parkinson(ism) and is involved in this project. Additionally, the Dutch Parkinson Scientists (DPS) Association, a society for Parkinson's researchers in the Netherlands, is involved. Parkinson's UK is also involved.

Expected Results

We will identify biomarkers for disease progression and validate them in bodily material from people with Parkinson's disease to stimulate the development of new drugs.