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Caging the dragon: translational approach to unravel and prevent COVID-19 associated thrombosis

Projectomschrijving

Bij COVID-19 patiënten is het aantal gevallen van veneuze trombo-embolie (VTE), zoals een trombosebeen of longembolie, opmerkelijk hoog, tot 48% op de IC. De aanwezigheid van VTE zorgt voor ernstiger ziektegevallen en een verhoogd aantal sterftegevallen. Bovendien treedt VTE op ondanks preventieve behandeling met bloedverdunners (heparine). Dit kan duiden op heparineresistentie of de mogelijkheid dat de behandeling met heparine niet de (enige) oplossing is. Om de best mogelijke behandeling van COVID-19-patiënten te vinden, moeten het ziekteproces en risicofactoren worden begrepen, evenals de veiligheid en werkzaamheid van de momenteel voorgeschreven tromboseprofylaxe en behandeling.

Onderzoek

In het onderzoek worden de exacte omvang van het aantal VTE-gevallen in Nederland en het effect van de preventieve behandeling met heparine bestudeerd, risicofactoren geïdentificeerd en moet worden voorspeld welke factoren hieraan bijdragen. Tevens wordt aan de hand van laboratoriumonderzoek inzicht verkregen in het ontstaan van VTE. Om te onderscheiden of VTE bij COVID-19 patiënten het resultaat is van een direct effect van het virus of indirect via het afweersysteem, wordt een combinatie van klinische cohortstudies met diepgaande in vivo en in vitro studies uitgevoerd. Om het risico op VTE te voorspellen bij opgenomen COVID-19-patiënten worden patiëntgegevens verzameld en VTE-patiënten geïdentificeerd. Er worden dynamische voorspellingsmodellen ontwikkeld en individuele VTE-risico's ingeschat. COVID-19-patiënten zullen worden gevolgd op de langetermijneffecten van de long- en hartfunctie, functionele status en kwaliteit van leven.

Het project wordt uitgevoerd door het consortium Dutch COVID & Thrombosis Coalition. Hierin participeren alle umc’s en Sanquin. Daarnaast wordt er samengewerkt met meerdere algemene ziekenhuizen. Het onderzoek wordt mede gefinancierd door Trombosestichting Nederland.

Producten

Titel: Serial EXTEM, FIBTEM, and tPA Rotational Thromboelastometry Observations in the Maastricht Intensive Care COVID Cohort-Persistence of Hypercoagulability and Hypofibrinolysis Despite Anticoagulation
Auteur: Anne-Marije Hulshof, Renée A G Brüggemann, Mark M G Mulder, Tom W van de Berg, Jan-Willem E M Sels, Renske H Olie, Bart Spaetgens, Alexander S Streng, Paul Verhezen, Iwan C C van der Horst, Hugo Ten Cate, Henri M H Spronk, Bas C T van Bussel, Yvonne M C Henskens
Magazine: Front Cardiovasc Med
Titel: Thrombotic events in COVID-19 are associated with a lower use of prophylactic anticoagulation before hospitalization and followed by decreases in platelet reactivity
Auteur: Chantal C. Clark, Bernard N. Jukema, Arjan D. Barendrecht, Judith S. Spanjaard, Nikita K. Jorritsma, Simone Smits, Steven de Maar, Cor W. Seinen, Sandra Verhoef, Naomi M. Parr, Silvie A. Sebastian, Arnol C. Koekman, Annet C. van Wesel, Harriet M. van Goor, Roy Spijkerman, Suzanne H. Bongers, Erhard van der Vries, Stefan Nierkens, Marianne Boes, Leo Koenderman, Karin A. Kaasjager and Coen Maas
Magazine: Frontiers in Medicine
Titel: Ruling out Pulmonary Embolism in Patients with (Suspected) COVID-19-A Prospective Cohort Study
Auteur: Milou A M Stals, Fleur H J Kaptein, Remy H H Bemelmans, Thomas van Bemmel, Inge C Boukema, Dionne C W Braeken, Sander J E Braken, Carlinda Bresser, Hugo Ten Cate, Duco D Deenstra, Yordi P A van Dooren, Laura M Faber, Marco J J H Grootenboers, Lianne R de Haan, Carolien Haazer, Antonio Iglesias Del Sol, Sarah Kelliher, Ted Koster, Lucia J M Kroft, Rick I Meijer, Fleur Pals, Eric R E van Thiel, Peter E Westerweel, Marije Ten Wolde, Frederikus A Klok, Menno V Huisman; Dutch COVID & Thrombosis Coali
Magazine: TH Open
Titel: The Immediate Effect of COVID-19 Vaccination on Anticoagulation Control in Patients Using Vitamin K Antagonists
Auteur: Chantal Visser?, Joseph S. Biedermann, Melchior C. Nierman?, Felix J.M. van der Meer, Anouk J.W. Gulpen, Yvonne C.F. Moors, Suzanne C. Cannegieter, Willem M. Lijfering, Marieke J.H.A. Kruip, on behalf of the Dutch COVID & Thrombosis Coalition
Magazine: Thrombosis and Haemostasis
Titel: Incidence of thrombotic complications and overall survival in hospitalized patients with COVID-19 in the second and first wave
Auteur: FHJ Kaptein, MAM Stals, MJJH Grootenboers, SJE Braken, JLI Burggraaf, BCT van Bussel, SC Cannegieter, H ten Cate, H Endeman, DAMPJ Gommers, C van Guldener, E de Jonge, NP Juffermans, KM Kant, ME Kevenaar, S Koster, LJM Kroft, MJHA Kruip, J Leentjens, C Marechal, YL Soei, L Tjepkema, C Visser, FA Klok, MV Huisman
Magazine: Thrombosis Research
Link: https://www.sciencedirect.com/science/article/pii/S0049384820306757?via%3Dihub
Titel: Pre-admission anticoagulant therapy and mortality in hospitalized COVID-19 patients: A retrospective cohort study
Auteur: Thijs F van Haaps, Didier Collard, Frits H M van Osch, Saskia Middeldorp, Michiel Coppens, Martijn D de Kruif, Eline A Vlot, Renée A Douma, Hugo Ten Cate, Nicole P Juffermans, Niels Gritters, Alexander P Vlaar, Auke C Reidinga, Marjolein A Heuvelmans, Matthijs Oudkerk, Harry R Büller, Joop P W van den Bergh, Arno Maas, Marije Ten Wolde, Suat Simsek; Corona Research Fund Amsterdam UMC; Martijn Beudel, Nick van Es; Dutch COVID & Thrombosis Coalition
Magazine: Thrombosis Research
Titel: Altered fibrin network structure and fibrinolysis in intensive care unit patients with COVID-19, not entirely explaining the increased risk of thrombosis
Auteur: Judith J de Vries, Chantal Visser, Lotte Geers, Johan A Slotman, Nadine D van Kleef, Coen Maas, Hannelore I Bax, Jelle R Miedema, Eric C M van Gorp, Marco Goeijenbier, Johannes P C van den Akker, Henrik Endeman, Dingeman C Rijken, Marieke J H A Kruip, Moniek P M de Maat
Magazine: Journal of Thrombosis and Haemostasis
Titel: Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model
Auteur: Iris C Kreft, Roy R A Winiarczyk, Fric J Tanis, Carmen van der Zwaan, Katharina S Schmitz, Arie J Hoogendijk, Rik L de Swart, Anne Moscona, Matteo Porotto, Daniela C F Salvatori, Rory D de Vries, Moniek P M de Maat, Maartje van den Biggelaar, Bart J M van Vlijmen; Dutch Covid-19 and Thrombosis Coalition (DCTC)
Magazine: Thrombosis Research
Titel: Stability of vitamin K antagonist anticoagulation after COVID-19 diagnosis
Auteur: Eleonora Camilleri MD, Nienke van Rein PhD, Felix J.M. van der Meer MD, PhD, Melchior C. Nierman MD, PhD, Willem M. Lijfering MD, PhD, Suzanne C. Cannegieter MD, PhD, on behalf of The Dutch COVID & Thrombosis Coalition
Magazine: Research and Practice in Thrombosis and Haemostasis
Titel: Risk of thrombotic complications in influenza versus COVID-19 hospitalized patients
Auteur: Milou A M Stals, Marco J J H Grootenboers, Coen van Guldener, Fleur H J Kaptein, Sander J E Braken, Qingui Chen, Gordon Chu, Erik M van Driel, Antonio Iglesias Del Sol, Evert de Jonge, K Merijn Kant, Fleur Pals, Myrthe M A Toorop, Suzanne C Cannegieter, Frederikus A Klok, Menno V Huisman; Dutch COVID & Thrombosis Coalition (DCTC)
Magazine: Research and Practice in Thrombosis and Haemostasis
Titel: Estimating incidence of venous thromboembolism in COVID-19: Methodological considerations
Auteur: Linda Nab, Rolf H H Groenwold, Frederikus A Klok, Soerajja Bhoelan, Marieke J H A Kruip, Suzanne C Cannegieter
Magazine: Research and Practice in Thrombosis and Haemostasis
Titel: Early effects of unfractionated heparin on clinical and radiological signs and D-dimer levels in patients with COVID-19 associated pulmonary embolism: An observational cohort study
Auteur: Dutch COVID & Thrombosis Coalition (DCTC)
Magazine: Thrombosis Research
Titel: Population pharmacokinetics of nadroparin for thromboprophylaxis in COVID-19 intensive care unit patients
Auteur: Lorenzo G R Romano, Nicole G M Hunfeld, Marieke J H A Kruip, Henrik Endeman, Tim Preijers
Magazine: British Journal of Clinical Pharmacology
Titel: Chronic thromboembolic pulmonary hypertension and clot resolution after COVID-19-associated pulmonary embolism
Auteur: Cindy M.M. de Jong, Chantal Visser, Remy H.H. Bemelmans, Wim G. Boersma, Bram van den Borst, J. Louise I. Burggraaf, Suzanne C. Cannegieter, Arina J. ten Cate-Hoek, F. Nanne Croles, Harald J. Faber, Laura M. Faber, Merel E. Hellemons, Lisa M. Hessels, Menno V. Huisman, Pieter W. Kamphuisen, Stephanie C.E. Koster, Lucia J.M. Kroft, Ivo van der Lee, Jenneke Leentjens, Karina Meijer, Maarten K. Ninaber, Brigitte M. Sondermeijer, Susanne Stads, Anton Vonk Noordegraaf, Kristien Winckers, Marieke J.H.
Magazine: European Respiratory Journal
Titel: Caging the dragon: Research approach to COVID-19–related thrombosis
Auteur: Marieke J. H. A. Kruip MD, PhD Suzanne C. Cannegieter MD, PhD Hugo ten Cate MD, PhD Eric C. M. van Gorp MD, PhD Nicole P. Juffermans MD, PhD Frederikus A. Klok MD, PhD Coen Maas PhD Anton Vonk-Noordegraaf MD, PhD on behalf of the Dutch COVID Thrombosis Coalition study group
Magazine: Research and Practice in Thrombosis and Haemostasis
Titel: Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units: A retrospective cohort study
Auteur: Tessa Noordermeer, Roger E G Schutgens, Chantal Visser, Emma Rademaker, Moniek P M de Maat, A J Gerard Jansen, Maarten Limper, Olaf L Cremer, Marieke J H A Kruip, Henrik Endeman, Coen Maas, Bas de Laat, Rolf T Urbanus; Dutch COVID & Thrombosis Coalition (DCTC)
Magazine: Research and Practice in Thrombosis and Haemostasis
Titel: Risk of thrombotic complications in influenza versus COVID-19 hospitalized patients
Auteur: Milou A.M. Stals MD1?| Marco J.J.H. Grootenboers MD, PhD2?| Coen van GuldenerMD, PhD3?| Fleur H.J. Kaptein MD1?| Sander J.E. Braken BSc1?| Qingui Chen MD4?| Gordon Chu MD1?| Erik M. van Driel MD5?| Antonio Iglesias del Sol MD, PhD6?| Evert de Jonge MD, PhD7?| K. Merijn Kant MD8?| Fleur Pals BSc1?| Myrthe M. A. Toorop MD4?| Suzanne C. Cannegieter MD, PhD1,4?| Frederikus A. Klok MD, PhD1?| Menno V. Huisman MD, PhD1?| on behalf of the Dutch COVID & Thrombosis Coalit
Magazine: Research and Practice in Thrombosis and Haemostasis
Titel: Suggestions for global coagulation assays for the assessment of COVID-19 associated hypercoagulability
Auteur: Tom W.van de Berg, Anne-Marije M.Hulshof, Magdolna Nagya, Rene van Oerleb, Jan-Willem Sels, Basvan Bussel, Hugo ten Cate, Yvonne Henskens, Henri M.H.Spronk, Dutch Covid-19 and Thrombosis Coalition (DCTC)
Magazine: Thrombosis Research
Titel: Altered Fibrin Network Structure and Fibrinolysis in Intensive Care Unit Patients with COVID-19, Not Entirely Explaining the Increased Risk of Thrombosis
Auteur: J. de Vries, C. Visser, L. Geers, J. Slotman, N. van Kleef, C. Maas, H. Bax, J. Miedema, E. van Gorp, M. Goeijenbier, J. van den Akker, H. Endeman, D. Rijken, M. Kruip, M. de Maat
Titel: Stability of Oral Anticoagulant Treatment with Vitamin K Antagonists in COVID-19 Patients
Auteur: E. Camilleri, N. van Rein, F.J.M. van der Meer, M.C. Nierman, W.M. Lijfering, S.C. Cannegieter
Titel: The immediate effect of COVID-19 vaccination on anticoagulation control in patients using vitamin K antagonists
Auteur: Chantal Visser, Joseph S. Biedermann, Melchior C. Nierman, Felix J.M. van der Meer, Anouk J.W. Gulpen, Yvonne C.F. Moors, Suzanne C. Cannegieter, Willem M. Lijfering, Marieke J.H.A. Kruip, on behalf of the Dutch COVID & Thrombosis Coalition
Titel: Oversterfte verpleeghuizen
Auteur: K. Meijer
Titel: Prevalence of chronic thromboembolic pulmonary hypertension and evaluation of thrombus resolution in COVID-19-associated pulmonary embolism survivors
Auteur: Cindy M.M. de Jong, Chantal Visser, Remy H.H. Bemelmans, Wim G. Boersma, Bram van den Borst, J. Louise I. Burggraaf, Suzanne C. Cannegieter, Arina J. ten Cate-Hoek, F. Nanne Croles, Harald J. Faber, Laura M. Faber, Merel E. Hellemons, Lisa M. Hessels, Menno V. Huisman, Pieter W. Kamphuisen, Stephanie C.E. Koster, Lucia J.M. Kroft, Ivo van der Lee, Jenneke Leentjens, Karina Meijer, Maarten K. Ninaber, Brigitte M. Sondermeijer, Susanne Stads, Anton Vonk Noordegraaf, Kristien Winckers, Marieke J.H.
Titel: Lower excess mortality in an anticoagulated population during the first wave of the COVID-19 pandemic in the Netherlands
Auteur: Dutch COVID & Thrombosis Coalition
Titel: Excess Mortality in a Population of Vitamin K Antagonist Users during the First Wave of the COVID-19 Pandemic in the Netherlands Compared with Excess Mortality in the General Dutch Population
Auteur: Q. Chen, M.M.A. Toorop, C. Visser, F.J.M. van der Meer, M.C. Nierman, L. Goede, H. ten Cate, M.J.H.A. Kruip, W.M. Lijfering, S.C. Cannegieter, Dutch COVID & Thrombosis Coalition
Titel: Lower excess mortality in an anticoagulated population during the first wave of the COVID-19 pandemic in the Netherlands
Auteur: Q. Chen, M. Toorop, C. Visser, M. Nierman, F. van der Meer, L. Goede, A. ten Cate-Hoek, B. Spaetgens, C. den Uil, F. Klok, E. van Gorp, G.-J. Geersing, K. Meijer, C. Kramers, L. Faber, M. Huisman, N. van Es, R. Brüggemann, S. Middeldorp, V. Tichelaar, H. ten Cate, M. Kruip, W. Lijfering, S. Cannegieter
Titel: Diagnostic management of suspected pulmonary embolism in patients with COVID-19: a prospective cohort
Auteur: M.A.M. Stals, F.HJ Kaptein, RHH Bemelmans, T van Bemmel, DCW Braeken, DD Deenstra, YPA van Dooren, LM Faber, MJJH Grootenboers, LR de Haan, C Haazer, A Iglesias del Sol, S Kelliher, RI Meijer, PE Westerweel, FA Klok, MV Huisman, on behalf of the Dutch COVID & Thrombosis Coalition (DCTC)
Titel: AIM 2. The status of the fibrinolytic system
Auteur: C. Maas
Titel: Stand van zaken COVID-19 en trombose
Auteur: Marieke Kruip
Titel: COVID-19 Vaccination and Anticoagulation: Potential Effects on Anticoagulation Control in Patients Using Vitamin K Antagonists
Auteur: C. Visser, J.S. Biedermann, M.C. Nierman, F.J.M. van der Meer, S.C. Cannegieter, W.M. Lijfering, M.J.H.A. Kruip
Titel: The Impact Of Pulmonary Embolism On The Long-Term Health Outcomes Of COVID-19
Auteur: Chantal Visser, Julia C. Berentschot, Cindy M.M. de Jong, M. Louisa Antoni, Rita J.G. van den Berg-Emons, Bram van den Borst, Hugo ten Cate, Arina ten CateHoek, Dionne Braeken, J.J. Miranda Geelhoed, Majanka H. Heijenbrok-Kal, Lucia J.M. Kroft, Jenneke Leentjens, Anna H.E. Roukens, Suzanne C. Cannegieter, Frederik A. Klok, Merel E. Hellemons, Marieke J. H. A. Kruip, on behalf of the Dutch Covid & Thrombosis coalition
Titel: Plasma Proteomics In The Diagnosis And Risk Prediction Of Thrombotic Events
Auteur: Eva R. Smit, Iris C. Kreft, Eleonora Camilleri, Louise Burggraaf, Nienke van Rein, Bart J.M. van Vlijmen, Anne-Marije Hulshof, Bas van Bussel, Frank van Rosmalen, Tom van de Berg, Yvonne Henskens, Hugo ten Cate, Jonathan Coutinho, Marieke Kruip, Jeroen Eikenboom, Suzanne C. Cannegieter, Maartje van den Biggelaar, in collaboration with BEAT-COVID group and Dutch COVID & Thrombosis Coalition
Titel: Population pharmacokinetics of anti-Xa levels in COVID-19 ICU patients receiving prophylaxis for thrombo-embolic events using nadroparin
Auteur: L.G.R. Romano, M.J.H.A. Kruip, H. Endeman, N.G.M. Hunfeld, T. Preijers
Titel: Dutch Covid & thrombosis Coalition: update of research
Auteur: C. Visser
Titel: The immediate effect of COVID-19 vaccination on anticoagulation control in adolescents and young adults using vitamin K antagonists.
Auteur: C. Visser, A. Yousefi, M. Nierman, M. Huisman, A. Gulpen, C. van Ommen, M. Kruip
Titel: Population pharmacokinetics of anti-Xa levels in COVID-19 ICU patients receiving prophylaxis for thrombo-embolic events using nadroparin
Auteur: L.G.R. Romano, M.J.H.A Kruip, H. Endeman, N.G.M. Hunfeld, T. Preijgers
Titel: Lupus anticoagulant as predictor for thrombosis in critically ill COVID-19 patients: a retrospective cohort study
Auteur: T. Noordermeer, R. Schutgens, C. Visser, E. Rademaker, M. de Maat, A. Jansen, M. Limper, O. Cremer, M. Kruip, H. Endeman, C. Maas, B. de Laat, R. Urbanus
Titel: Increased Percentage of Extended Aa Chain Fibrinogen (aE) in COVID-19 Patients
Auteur: J. de Vries, C. Visser, M. van Ommen, C. Rokx, E. van Nood, E. van Gorp, M. Goeijenbier, J. van den Akker, H. Endeman, D. Rijken, M. Kruip, M. Weggeman, J. Koopman, M. de Maat
Titel: Stand van zaken COVID-19 en trombose
Auteur: Marieke Kruip
Titel: Mass spectrometry-based plasma Profiling
Auteur: Proteomics lab Molecular & Cellular Hemostasis Sanquin Research
Titel: Thrombosis prophylaxis study
Auteur: L. Nab
Titel: Stability of oral anticoagulant treatment with vitamin K antagonists in COVID-19 patients
Auteur: E. Camilleri, N. van Rein, F. J. M. van der Meer, M. C. Nierman, W. M. Lijfering, S. C. Cannegieter
Titel: Thrombosis in SARS-CoV-2 Infected Lung Tissue: Artificial intelligence aided segmentation and 3D modelling of fatal thrombotic events
Auteur: Teodora E. Trandafir, Elaine M.L. Ho, Boaz V. Lopuhaä, Farhan Akram, Matthew J . Lawson, Janina L . Wolf, Eleni Konstantinopoulou, Orestis L . Katsamenis, Andrew P . Stubbs, Yunlei Li, Philipp Schneider, Jan H. von der Thüsen
Titel: Thrombosis in SARS CoV 2 Infected Lung Tissue: Proteome Analysis of Lung Parenchyma, Isolated Endothelium and Thrombi
Auteur: Boaz V. Lopuhaä, Coskun Guzel, Anabel van der Lee, Thierry van den Bosch, Folkert J. van Kemenade, Menno V. Huisman, Marieke J.H.A. Kruip, Theo M. Luider, Jan H. von der Thüsen
Titel: DATA DEFINITIONS DUTCH COVID THROMBOSIS CONSORTIUM
Auteur: L. Nab, Leiden University Medical Center C. Visser, Erasmus Medical Center Rotterdam Prof. S.C Cannegieter, Leiden University Medical Center Dr. M. Coppens, Amsterdam University Medical Center Dr. F.A. Klok, Leiden University Medical Center Dr. M.J.H.A Kruip, Erasmus Medical Center Rotterdam
Titel: Tromboseprofylaxe bij COVID-19
Auteur: M.V. Huisman, F.A. Klok, H.C.J. Eikenboom, S. Middeldorp, M.J.H.A. Kruip, K. Meijer, M. Coppens, P.W. Kamphuisen, M.C.A. Müller, J.P.J. Wester, R. Vink, L.M. van den Toorn, R.G. Tieleman, J. Diepstraten, N. van Rein, N. Buenen, Y.C.M. Henskens
Titel: Geen daling in trombotische complicaties bij opgenomen COVID-19-patiënten in tweede golf
Auteur: Fleur Kaptein
Titel: FNT Nascholingsdag 2022
Auteur: Marieke Kruip
Titel: DCTC twitter
Auteur: the Dutch COVID & Thrombosis Coalition
Link: https://twitter.com/CovidDutch
Titel: the Dutch COVID & Thrombosis Coalition website
Auteur: C. Visser, M. Visser, M. J. H. A. Kruip, F. A. Klok, E. C. M. van Gorp, S. C. Cannegieter, H. ten Cate, C. Maas
Link: http://www.dutchcovidandthrombosiscoalition.com
Titel: Unraveling hypercoagulability in COVID-19 and optimizing VTE management in the frail nursing home population
Auteur: Renée Renate Anne Gezina Brüggemann

Verslagen


Samenvatting van de aanvraag

RELEVANCE The incidence of venous thromboembolic events (VTE) in COVID-19 patients is remarkably high, up to 48% on ICU despite thromboprophylaxis, suggesting a procoagulant state. Several underlying mechanisms have been suggested. To find the best possible treatment of COVID-19 patients we need to understand the pathogenesis and risk factors as well as the safety and efficacy of currently prescribed thromboprophylaxis and treatment. OBJECTIVE AND STRATEGY OVERALL OBJECTIVE: to understand and prevent VTE in COVID-19 patients and optimize acute treatment and long term health of COVID-19 patients with VTE A. PATHOGENESIS IN VIVO OBJECTIVE: To unravel pathophysiological mechanisms that cause COVID-19 associated coagulopathy STRATEGY: We will investigate 1) Prothrombotic antiphospholipid antibodies 2) Fibrinolysis 3) Coagulation and anticoagulants 4) Thrombus composition 5) OMICS. Multi-center expert teams are in place to investigate responsible mechanisms in plasma samples and tissue specimens. Most areas contain hypothesis-driven research with existing technologies, the OMICS approach should provide new insights in a hypothesis-free manner. IN VITRO OBJECTIVE: To identify the molecular mechanisms of SARS-CoV-2 induced thrombosis using in vitro infection models of pulmonary vascular bed. Tropism of SARS-CoV-2-infected endothelial cells will be compared to other respiratory viruses that cause VTE. STRATEGY: In vitro models study SARS-CoV2 kinetics and dynamics and their effect on endothelial cells and co-culture models and their role in inducing a procoagulant state. Data will be related to pathology observations in autopsies. B. THROMBOPROPHYLAXIS AND TREATMENT OF THROMBOSIS OBJECTIVE: To define the optimal strategies for prevention and treatment of VTE in COVID-19 patients STRATEGY: Combining all available observational evidence from established registries and targeted collection in cohorts, changes in prophylaxis can be linked to outcomes. We facilitate participation in REMAP-CAP-COVID-19 study to compare therapeutic dose with standard dose prophylaxis. Using global clotting assays on biobanked samples, biochemical efficacy of anticoagulation treatment is evaluated. C. BIOMARKERS AND PREDICTION OF THROMBOSIS OBJECTIVE: To predict the risk of VTE in admitted COVID-19 patients STRATEGY: Patients data will be collected and VTE patients identified. Dynamic prediction models will be developed to estimate individual VTE risks. The predictive values will be compared for different mechanistic pathways, VTE phenotypes for ICU and non-ICU patients. D. LONG TERM CONSEQUENCES OF VTE OBJECTIVE: To assess the impact and long-term consequences of VTE in COVID-19 patients STRATEGY: COVID-19 patients will be followed for long-term effects on pulmonary and cardiac function, functional status and quality of life. The incidence of post-VTE syndrome will be determined compared to COVID-19 patients without VTE and non-COVID-19 VTE patients.

Onderwerpen

Kenmerken

Projectnummer:
10430012010004
Looptijd: 90%
Looptijd: 90 %
2020
2024
Onderdeel van programma:
Gerelateerde subsidieronde:
Projectleider en penvoerder:
dr. M.J.H.A. Kruip
Verantwoordelijke organisatie:
Erasmus Medisch Centrum